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Must Read
F1000 Factor 6.0

New Finding
 Memory CD8 T-cell compartment grows in size with immunological experience.
Vezys V, Yates A, …, Antia R, Masopust D
Nature 2008 Nov 12 [abstract on PubMed] [related articles] [full text]
Selected by | Barry Rouse
Evaluated 18 Nov 2008

Recommended
F1000 Factor 3.0

Confirmation
New Finding
 The effector T cells of diabetic subjects are resistant to regulation via CD4+ FOXP3+ regulatory T cells.
Schneider A, Rieck M, …, Greenbaum C, Buckner JH
J Immunol 2008 Nov 15 181(10):7350-5 [abstract on PubMed] [related articles] [order article]
Selected by | Matthias von Herrath with Christophe Filippi
Evaluated 14 Nov 2008

Recommended
F1000 Factor 3.0

Hypothesis
New Finding
 Human basophils and eosinophils are the direct target leukocytes of the novel IL-1-family member IL-33.
Pecaric-Petkovic T, Didichenko SA, …, Spiegl N, Dahinden CA
Blood 2008 Oct 27 [abstract on PubMed] [related articles] [full text]
Selected by | Marc Rothenberg with Ariel Munitz
Evaluated 13 Nov 2008

Must Read
F1000 Factor 6.0

New Finding
Controversial
 IL-17-producing alveolar macrophages mediate allergic lung inflammation related to asthma.
Song C, Luo L, …, Huang B, Feng ZH
J Immunol 2008 Nov 1 181(9):6117-24 [abstract on PubMed] [related articles] [order article]
Selected by | Dan Conrad
Evaluated 11 Nov 2008

Must Read
F1000 Factor 6.0

New Finding
Novel Drug Target
 T-cell-expressed proprotein convertase furin is essential for maintenance of peripheral immune tolerance.
Pesu M, Watford WT, …, Creemers J, O'Shea JJ
Nature 2008 Sep 11 455(7210):246-50 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Robert Fuller
Evaluated 10 Nov 2008

Recommended
F1000 Factor 3.0

Tech Advance
 Real-time imaging of the intracellular glutathione redox potential.
Gutscher M, Pauleau AL, …, Meyer AJ, Dick TP
Nat Methods 2008 Jun 5(6):553-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Ruma Banerjee
Evaluated 5 Nov 2008

Recommended
F1000 Factor 3.0

Confirmation
New Finding
 Primary biliary cirrhosis is associated with a genetic variant in the 3' flanking region of the CTLA4 gene.
Juran BD, Atkinson EJ, …, Fridley BL, Lazaridis KN
Gastroenterology 2008 Oct 135(4):1200-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Bruno Stieger
Evaluated 3 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
Novel Drug Target
 ROCK1 mediates leukocyte recruitment and neointima formation following vascular injury.
Noma K, Rikitake Y, …, Sun J, Liao JK
J Clin Invest 2008 May 118(5):1632-44 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Ivan McMurtry
Evaluated 3 Nov 2008

Must Read
F1000 Factor 6.0

Hypothesis
New Finding
Controversial
 Transforming growth factor-beta 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset.
Veldhoen M, Uyttenhove C, …, Wilhelm C, Stockinger B
Nat Immunol 2008 Oct 19 [abstract on PubMed] [related articles] [full text]
Selected by | Peter Openshaw
Evaluated 3 Nov 2008

Must Read
F1000 Factor 6.0

New Finding
 TH17 cells mediate steroid-resistant airway inflammation and airway hyperresponsiveness in mice.
McKinley L, Alcorn JF, …, Ray A, Kolls JK
J Immunol 2008 Sep 15 181(6):4089-97 [abstract on PubMed] [related articles] [order article]
Selected by | Dan Conrad
Evaluated 31 Oct 2008


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