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Must Read
F1000 Factor 6.0

Hypothesis
New Finding
 Aire controls the differentiation program of thymic epithelial cells in the medulla for the establishment of self-tolerance.
Yano M, Kuroda N, …, Mouri Y, Matsumoto M
J Exp Med 2008 Nov 17 [abstract on PubMed] [related articles] [full text]
Selected by | David Chaplin
Evaluated 19 Nov 2008

Must Read
F1000 Factor 6.0

New Finding
 CD40L+ CD4+ memory T cells migrate in a CD62P-dependent fashion into reactive lymph nodes and license dendritic cells for T cell priming.
Martín-Fontecha A, Baumjohann D, …, Lanzavecchia A, Sallusto F
J Exp Med 2008 Oct 27 205(11):2561-74 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Linda Bradley
Evaluated 14 Nov 2008

Must Read
F1000 Factor 6.0

New Finding
Controversial
 IL-17-producing alveolar macrophages mediate allergic lung inflammation related to asthma.
Song C, Luo L, …, Huang B, Feng ZH
J Immunol 2008 Nov 1 181(9):6117-24 [abstract on PubMed] [related articles] [order article]
Selected by | Dan Conrad
Evaluated 11 Nov 2008

Recommended
F1000 Factor 3.0

Hypothesis
 Activation of a dendritic cell-T cell axis by Ad5 immune complexes creates an improved environment for replication of HIV in T cells.
Perreau M, Pantaleo G, Kremer EJ
J Exp Med 2008 Nov 3 [abstract on PubMed] [related articles] [full text]
Selected by | Lindsey Hutt-Fletcher
Evaluated 6 Nov 2008


Must Read
F1000 Factor 6.0

New Finding
Refutation
 The exception that reinforces the rule: crosspriming by cytosolic peptides that escape degradation.
Lev A, Takeda K, …, Bennink JR, Yewdell JW
Immunity 2008 Jun 28(6):787-98 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Laurence Eisenlohr
Evaluated 4 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
 Cutting edge: TLR ligands increase TCR triggering by slowing peptide-MHC class I decay rates.
Rudd BD, Brien JD, Davenport MP, Nikolich-Zugich J
J Immunol 2008 Oct 15 181(8):5199-203 [abstract on PubMed] [related articles] [order article]
Selected by | E. Charles Snow
Evaluated 29 Oct 2008

Must Read
F1000 Factor 6.0

Hypothesis
New Finding
Novel Drug Target
 The innate NK cells, allograft rejection, and a key role for IL-15.
Kroemer A, Xiao X, …, Demirci G, Li XC
J Immunol 2008 Jun 15 180(12):7818-26 [abstract on PubMed] [related articles] [order article]
Selected by | Gerald Spangrude
Evaluated 29 Oct 2008

Must Read
F1000 Factor 4.8

New Finding
Novel Drug Target
 Plasmacytoid dendritic cells mediate oral tolerance.
Goubier A, Dubois B, …, Trinchieri G, Kaiserlian D
Immunity 2008 Sep 29(3):464-75 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Luciano Adorini / Maria Rescigno
First evaluation 23 Oct 2008 | Latest evaluation 24 Oct 2008

Must Read
F1000 Factor 6.7

Confirmation
New Finding
Controversial
 CTLA-4 control over Foxp3+ regulatory T cell function.
Wing K, Onishi Y, …, Nomura T, Sakaguchi S
Science 2008 Oct 10 322(5899):271-5 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Richard Williams / Kenneth Tung with Alberta Paul / Jay Berzofsky / Arthur Hurwitz
First evaluation 22 Oct 2008 | Latest evaluation 12 Nov 2008


Must Read
F1000 Factor 6.5

New Finding
Novel Drug Target
 Transcription factor E2-2 is an essential and specific regulator of plasmacytoid dendritic cell development.
Cisse B, Caton ML, …, Zhuang Y, Reizis B
Cell 2008 Oct 3 135(1):37-48 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Brigitte Huber / Marco Colonna / David Allman with Benjamin Harman
First evaluation 22 Oct 2008 | Latest evaluation 31 Oct 2008


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