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Recommended
F1000 Factor 3.0

Confirmation
New Finding
 Genomic surveys by methylation-sensitive SNP analysis identify sequence-dependent allele-specific DNA methylation.
Kerkel K, Spadola A, …, Haghighi F, Tycko B
Nat Genet 2008 Jul 40(7):904-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Stephan Beck
Evaluated 5 Sep 2008

Recommended
F1000 Factor 3.0

Hypothesis
New Finding
Controversial
 Structural and functional evidence that Nck interaction with CD3epsilon regulates T-cell receptor activity.
Takeuchi K, Yang H, …, Reinherz EL, Wagner G
J Mol Biol 2008 Jul 18 380(4):704-16 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Michael Dustin with Kaushik Choudhuri
Evaluated 4 Sep 2008

Recommended
F1000 Factor 3.0

Confirmation
New Finding
 Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease.
McCarroll SA, Huett A, …, Daly MJ, Xavier RJ
Nat Genet 2008 Aug 24 40 [abstract on PubMed] [related articles] [full text]
Selected by | Vojo Deretic with Isabelle Vergne
Evaluated 4 Sep 2008

Recommended
F1000 Factor 3.0

Confirmation
Controversial
Refutation
 Humans lack iGb3 due to the absence of functional iGb3-synthase: implications for NKT cell development and transplantation.
Christiansen D, Milland J, …, Godfrey DI, Sandrin MS
PLoS Biol 2008 Jul 15 6(7):e172 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Jonathan Howard
Evaluated 4 Sep 2008

Recommended
F1000 Factor 3.0

Confirmation
New Finding
Tech Advance
 A biochemically defined system for coding joint formation in V(D)J recombination.
Lu H, Shimazaki N, …, Swanson PC, Lieber MR
Mol Cell 2008 Aug 22 31(4):485-97 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Pierre Ferrier
Evaluated 3 Sep 2008

Must Read
F1000 Factor 6.0

Hypothesis
New Finding
Tech Advance
Controversial
Refutation
 Human interleukin 17-producing cells originate from a CD161+CD4+ T cell precursor.
Cosmi L, De Palma R, …, Romagnani S, Annunziato F
J Exp Med 2008 Aug 4 205(8):1903-16 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Mark Hogarth
Evaluated 3 Sep 2008

Recommended
F1000 Factor 3.0

Confirmation
 AID expression levels determine the extent of cMyc oncogenic translocations and the incidence of B cell tumor development.
Takizawa M, Tolarová H, …, Potter M, Casellas R
J Exp Med 2008 Aug 4 [abstract on PubMed] [related articles] [full text]
Selected by | Amy Kenter
Evaluated 2 Sep 2008

Exceptional
F1000 Factor 9.0

New Finding
Tech Advance
 Neutralizing antibodies derived from the B cells of 1918 influenza pandemic survivors.
Yu X, Tsibane T, …, Basler CF, Crowe Jr JE
Nature 2008 Aug 17 [abstract on PubMed] [related articles] [full text]
Selected by | Adolfo Garcia-Sastre
Evaluated 29 Aug 2008

Recommended
F1000 Factor 3.0

New Finding
Tech Advance
 HLA-DRB1*0401 and HLA-DRB1*0408 are strongly associated with the development of antibodies against interferon-beta therapy in multiple sclerosis.
Hoffmann S, Cepok S, …, Wasmuth R, Hemmer B
Am J Hum Genet 2008 Aug 83(2):219-27 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Murali Ramanathan
Evaluated 27 Aug 2008

Must Read
F1000 Factor 6.0

Hypothesis
New Finding
 Autophagy in thymic epithelium shapes the T-cell repertoire and is essential for tolerance.
Nedjic J, Aichinger M, …, Mizushima N, Klein L
Nature 2008 Aug 13 [abstract on PubMed] [related articles] [full text]
Selected by | Vojo Deretic
Evaluated 27 Aug 2008


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