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Must Read
F1000 Factor 6.0

New Finding
 Memory CD8 T-cell compartment grows in size with immunological experience.
Vezys V, Yates A, …, Antia R, Masopust D
Nature 2008 Nov 12 [abstract on PubMed] [related articles] [full text]
Selected by | Barry Rouse
Evaluated 18 Nov 2008

Must Read
F1000 Factor 6.0

New Finding
 CD40L+ CD4+ memory T cells migrate in a CD62P-dependent fashion into reactive lymph nodes and license dendritic cells for T cell priming.
Martín-Fontecha A, Baumjohann D, …, Lanzavecchia A, Sallusto F
J Exp Med 2008 Oct 27 205(11):2561-74 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Linda Bradley
Evaluated 14 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
Novel Drug Target
 Alternate mRNA splicing in multiple human tryptase genes is predicted to regulate tetramer formation.
Jackson NE, Wang HW, …, Cairns J, Hunt JE
J Biol Chem 2008 Oct 14 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Richard L. Stevens
Evaluated 13 Nov 2008

Must Read
F1000 Factor 6.0

New Finding
Novel Drug Target
 T-cell-expressed proprotein convertase furin is essential for maintenance of peripheral immune tolerance.
Pesu M, Watford WT, …, Creemers J, O'Shea JJ
Nature 2008 Sep 11 455(7210):246-50 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Robert Fuller
Evaluated 10 Nov 2008

Recommended
F1000 Factor 3.0

Controversial
Refutation
 Reductive isolation from bone marrow and blood implicates common lymphoid progenitors as the major source of thymopoiesis.
Serwold T, Ehrlich LI, Weissman IL
Blood 2008 Oct 16 [abstract on PubMed] [related articles] [full text]
Selected by | Hans-Reimer Rodewald
Evaluated 31 Oct 2008

Must Read
F1000 Factor 6.0

New Finding
 TH17 cells mediate steroid-resistant airway inflammation and airway hyperresponsiveness in mice.
McKinley L, Alcorn JF, …, Ray A, Kolls JK
J Immunol 2008 Sep 15 181(6):4089-97 [abstract on PubMed] [related articles] [order article]
Selected by | Dan Conrad
Evaluated 31 Oct 2008

Must Read
F1000 Factor 6.0

Hypothesis
New Finding
Novel Drug Target
 The innate NK cells, allograft rejection, and a key role for IL-15.
Kroemer A, Xiao X, …, Demirci G, Li XC
J Immunol 2008 Jun 15 180(12):7818-26 [abstract on PubMed] [related articles] [order article]
Selected by | Gerald Spangrude
Evaluated 29 Oct 2008

Recommended
F1000 Factor 3.0

New Finding
 Development of human plasmacytoid dendritic cells depends on the combined action of the basic helix-loop-helix factor E2-2 and the Ets factor Spi-B.
Nagasawa M, Schmidlin H, …, Schotte R, Blom B
Eur J Immunol 2008 Sep 38(9):2389-400 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Marco Colonna
Evaluated 28 Oct 2008

Recommended
F1000 Factor 3.0

New Finding
 Blimp-1 attenuates Th1 differentiation by repression of ifng, tbx21, and bcl6 gene expression.
Cimmino L, Martins GA, …, Perez RK, Calame KL
J Immunol 2008 Aug 15 181(4):2338-47 [abstract on PubMed] [related articles] [order article]
Selected by | Santa Jeremy Ono
Evaluated 27 Oct 2008

Recommended
F1000 Factor 3.0

New Finding
 The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance.
Akiyama T, Shimo Y, …, Takahama Y, Inoue J
Immunity 2008 Sep 29(3):423-37 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Mark Anderson with Jason Devoss
Evaluated 24 Oct 2008


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