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Browse > Immunology > Innate Immunity
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Must Read
F1000 Factor 6.0

Hypothesis
New Finding
 Aire controls the differentiation program of thymic epithelial cells in the medulla for the establishment of self-tolerance.
Yano M, Kuroda N, …, Mouri Y, Matsumoto M
J Exp Med 2008 Nov 17 [abstract on PubMed] [related articles] [full text]
Selected by | David Chaplin
Evaluated 19 Nov 2008

Recommended
F1000 Factor 3.0

Hypothesis
 Stimulation of Ebola virus production from persistent infection through activation of the Ras/MAPK pathway.
Strong JE, Wong G, …, Kobinger GP, Feldmann H
Proc Natl Acad Sci U S A 2008 Nov 3 105 [abstract on PubMed] [related articles] [full text]
Selected by | Kanta Subbarao with Catherine Luke
Evaluated 19 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
 Primary infection with simian immunodeficiency virus: plasmacytoid dendritic cell homing to lymph nodes, type I IFN, and immune suppression.
Malleret B, Maneglier B, …, Le Grand R, Vaslin B
Blood 2008 Sep 11 [abstract on PubMed] [related articles] [full text]
Selected by | Gene Shearer with Adriano Boasso
Evaluated 18 Nov 2008

Recommended
F1000 Factor 3.0

Confirmation
New Finding
 The effector T cells of diabetic subjects are resistant to regulation via CD4+ FOXP3+ regulatory T cells.
Schneider A, Rieck M, …, Greenbaum C, Buckner JH
J Immunol 2008 Nov 15 181(10):7350-5 [abstract on PubMed] [related articles] [order article]
Selected by | Matthias von Herrath with Christophe Filippi
Evaluated 14 Nov 2008

Recommended
F1000 Factor 3.0

Hypothesis
Controversial
Novel Drug Target
 Impaired parasympathetic function increases susceptibility to inflammatory bowel disease in a mouse model of depression.
Ghia JE, Blennerhassett P, Collins SM
J Clin Invest 2008 Jun 118(6):2209-18 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Ruud Buijs
Evaluated 14 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
Novel Drug Target
 Alternate mRNA splicing in multiple human tryptase genes is predicted to regulate tetramer formation.
Jackson NE, Wang HW, …, Cairns J, Hunt JE
J Biol Chem 2008 Oct 14 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Richard L. Stevens
Evaluated 13 Nov 2008

Recommended
F1000 Factor 3.0

Hypothesis
New Finding
 Human basophils and eosinophils are the direct target leukocytes of the novel IL-1-family member IL-33.
Pecaric-Petkovic T, Didichenko SA, …, Spiegl N, Dahinden CA
Blood 2008 Oct 27 [abstract on PubMed] [related articles] [full text]
Selected by | Marc Rothenberg with Ariel Munitz
Evaluated 13 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
 Substrains of 129 mice are resistant to Yersinia pestis KIM5: Implications for IL-10 deficient mice.
Turner JK, Xu JL, Tapping RI
Infect Immun 2008 Oct 27 [abstract on PubMed] [related articles] [full text]
Selected by | James Bliska
Evaluated 11 Nov 2008

Must Read
F1000 Factor 6.0

New Finding
Controversial
 IL-17-producing alveolar macrophages mediate allergic lung inflammation related to asthma.
Song C, Luo L, …, Huang B, Feng ZH
J Immunol 2008 Nov 1 181(9):6117-24 [abstract on PubMed] [related articles] [order article]
Selected by | Dan Conrad
Evaluated 11 Nov 2008

Must Read
F1000 Factor 6.0

New Finding
Novel Drug Target
 Triggering the succinate receptor GPR91 on dendritic cells enhances immunity.
Rubic T, Lametschwandtner G, …, Rot A, Carballido JM
Nat Immunol 2008 Nov 9(11):1261-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Mauro Teixeira
Evaluated 10 Nov 2008


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