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F1000 Factor 3.0

New Finding
Novel Drug Target
 The Death Receptor 3-TNF-like protein 1A pathway drives adverse bone pathology in inflammatory arthritis.
Bull MJ, Williams AS, …, Al-Shamkhani A, Wang EC
J Exp Med 2008 Sep 29 [abstract on PubMed] [related articles] [full text]
Selected by | Richard L. Stevens
Evaluated 10 Oct 2008

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F1000 Factor 6.0

New Finding
Novel Drug Target
 Interleukin 17-producing T helper cells and interleukin 17 orchestrate autoreactive germinal center development in autoimmune BXD2 mice.
Hsu HC, Yang P, …, Williams RW, Mountz JD
Nat Immunol 2008 Feb 9(2):166-75 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Antony Basten with Pablo Silveira
Evaluated 10 Oct 2008


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F1000 Factor 3.0

Tech Advance
 Functionally competent eosinophils differentiated ex vivo in high purity from normal mouse bone marrow.
Dyer KD, Moser JM, …, Percopo CM, Rosenberg HF
J Immunol 2008 Sep 15 181(6):4004-9 [abstract on PubMed] [related articles] [order article]
Selected by | Achsah Keegan
Evaluated 10 Oct 2008

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F1000 Factor 6.0

Hypothesis
 Beyond transcription factors: the role of chromatin modifying enzymes in regulating transcription required for memory.
Barrett RM, Wood MA
Learn Mem 2008 15(7):460-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Peter Rapp
Evaluated 9 Oct 2008

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F1000 Factor 3.0

New Finding
Tech Advance
 A novel biochemical method to identify target genes of individual microRNAs: Identification of a new Caenorhabditis elegans let-7 target.
Andachi Y
RNA 2008 Sep 29 [abstract on PubMed] [related articles] [full text]
Selected by | Morris Maduro
Evaluated 9 Oct 2008

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F1000 Factor 3.0

New Finding
Tech Advance
 Effects of spatially varying selection on nucleotide diversity and linkage disequilibrium: insights from deer mouse globin genes.
Storz JF, Kelly JK
Genetics 2008 Sep 180(1):367-79 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Thomas Mitchell-Olds
Evaluated 9 Oct 2008

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F1000 Factor 3.0

Hypothesis
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 A2B adenosine receptor signaling attenuates acute lung injury by enhancing alveolar fluid clearance in mice.
Eckle T, Grenz A, Laucher S, Eltzschig HK
J Clin Invest 2008 Oct 1 118(10):3301-3315 [abstract on PubMed] [related articles] [FREE full text]
Selected by | John Auchampach
Evaluated 9 Oct 2008

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F1000 Factor 3.0

New Finding
 Truncated tau expression levels determine life span of a rat model of tauopathy without causing neuronal loss or correlating with terminal neurofibrillary tangle load.
Koson P, Zilka N, …, Filipcik P, Novak M
Eur J Neurosci 2008 Jul 28(2):239-46 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | George Perry
Evaluated 9 Oct 2008

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F1000 Factor 6.0

Confirmation
Hypothesis
New Finding
 Speciation through sensory drive in cichlid fish.
Seehausen O, Terai Y, …, Imai H, Okada N
Nature 2008 Oct 2 455(7213):620-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Dolph Schluter
Evaluated 8 Oct 2008

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F1000 Factor 3.0

Hypothesis
New Finding
Novel Drug Target
 Histone deacetylase inhibitors decrease cocaine but not sucrose self-administration in rats.
Romieu P, Host L, …, Aunis D, Zwiller J
J Neurosci 2008 Sep 17 28(38):9342-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | George Breese with Katie Kelm
Evaluated 8 Oct 2008


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