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F1000 Factor 3.0

New Finding
 Spinocerebellar ataxia type 6 knockin mice develop a progressive neuronal dysfunction with age-dependent accumulation of mutant CaV2.1 channels.
Watase K, Barrett CF, …, Tsien RW, Zoghbi HY
Proc Natl Acad Sci U S A 2008 Aug 19 105(33):11987-92 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Annette Dolphin
Evaluated 6 Oct 2008

Recommended
F1000 Factor 3.0

Hypothesis
Tech Advance
 Rapid "open-source" engineering of customized zinc-finger nucleases for highly efficient gene modification.
Maeder ML, Thibodeau-Beganny S, …, Voytas DF, Joung JK
Mol Cell 2008 Jul 25 31(2):294-301 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Brian Kuhlman
Evaluated 3 Oct 2008

Recommended
F1000 Factor 3.0

New Finding
 Pharmacogenetics of cyclosporine in children suggests an age-dependent influence of ABCB1 polymorphisms.
Fanta S, Niemi M, …, Hoppu K, Backman JT
Pharmacogenet Genomics 2008 Feb 18(2):77-90 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | J. Steven Leeder
Evaluated 3 Oct 2008

Recommended
F1000 Factor 3.0

New Finding
 Solid-state NMR reveals structural differences between fibrils of wild-type and disease-related A53T mutant alpha-synuclein.
Heise H, Celej MS, …, Jovin TM, Baldus M
J Mol Biol 2008 Jul 11 380(3):444-50 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Stephen Eyles
Evaluated 1 Oct 2008

Must Read
F1000 Factor 6.0

Hypothesis
New Finding
 Kras regulatory elements and exon 4A determine mutation specificity in lung cancer.
To MD, Wong CE, …, Di Lauro R, Balmain A
Nat Genet 2008 Oct 40(10):1240-4 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Valeri Vasioukhin
Evaluated 30 Sep 2008

Recommended
F1000 Factor 3.0

New Finding
Tech Advance
 Disruption of the CFTR gene produces a model of cystic fibrosis in newborn pigs.
Rogers CS, Stoltz DA, …, Prather RS, Welsh MJ
Science 2008 Sep 26 321(5897):1837-41 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | William H. Colledge
Evaluated 30 Sep 2008

Recommended
F1000 Factor 3.0

Hypothesis
 Evolution of genomic imprinting with biparental care: implications for Prader-Willi and Angelman syndromes.
Ubeda F
PLoS Biol 2008 Aug 26 6(8):e208 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Russell Bonduriansky
Evaluated 29 Sep 2008

Must Read
F1000 Factor 4.8

New Finding
Novel Drug Target
 Platelet-derived growth factor-alpha receptor activation is required for human cytomegalovirus infection.
Soroceanu L, Akhavan A, Cobbs CS
Nature 2008 Sep 18 455(7211):391-5 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Ulf Pettersson / Andrius Kazlauskas
First evaluation 29 Sep 2008 | Latest evaluation 30 Sep 2008

Recommended
F1000 Factor 3.0

New Finding
Novel Drug Target
 A chemical screen in diverse breast cancer cell lines reveals genetic enhancers and suppressors of sensitivity to PI3K isoform-selective inhibition.
Torbett NE, Luna-Moran A, …, Shokat KM, Stokoe D
Biochem J 2008 Oct 1 415(1):97-110 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Simon Cook
Evaluated 29 Sep 2008

Must Read
F1000 Factor 6.0

Hypothesis
New Finding
Novel Drug Target
 PTEN-deficient cancers depend on PIK3CB.
Wee S, Wiederschain D, …, Yao YM, Lengauer C
Proc Natl Acad Sci U S A 2008 Sep 2 105(35):13057-62 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Simon Cook
Evaluated 29 Sep 2008


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