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Recommended
F1000 Factor 3.0

New Finding
Tech Advance
 Alternative isoform regulation in human tissue transcriptomes.
Wang ET, Sandberg R, …, Schroth GP, Burge CB
Nature 2008 Nov 2 [abstract on PubMed] [related articles] [full text]
Selected by | Ken Irvine with Yongqiang Feng
Evaluated 20 Nov 2008

Exceptional
F1000 Factor 9.0

Hypothesis
New Finding
Tech Advance
 Global reorganization of replication domains during embryonic stem cell differentiation.
Hiratani I, Ryba T, …, Schübeler D, Gilbert DM
PLoS Biol 2008 Oct 7 6(10):e245 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Joel Huberman
Evaluated 11 Nov 2008

Recommended
F1000 Factor 3.0

Tech Advance
 Efficient and accurate construction of genetic linkage maps from the minimum spanning tree of a graph.
Wu Y, Bhat PR, Close TJ, Lonardi S
PLoS Genet 2008 Oct 4(10):e1000212 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Derek Stemple
Evaluated 10 Nov 2008

Must Read
F1000 Factor 6.0

Confirmation
Tech Advance
 Deep sequencing-based expression analysis shows major advances in robustness, resolution and inter-lab portability over five microarray platforms.
't Hoen PA, Ariyurek Y, …, van Ommen GJ, den Dunnen JT
Nucleic Acids Res 2008 Oct 31 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Bernd Weisshaar
Evaluated 10 Nov 2008

Recommended
F1000 Factor 3.2

New Finding
Tech Advance
 Sequencing of natural strains of Arabidopsis thaliana with short reads.
Ossowski S, Schneeberger K, …, Warthmann N, Weigel D
Genome Res 2008 Oct 29 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Bernd Weisshaar / Julin Maloof with Jose M. Jimenez-Gomez
Evaluated 10 Nov 2008

Recommended
F1000 Factor 3.0

Confirmation
Tech Advance
 Systematic assessment of copy number variant detection via genome-wide SNP genotyping.
Cooper GM, Zerr T, …, Eichler EE, Nickerson DA
Nat Genet 2008 Oct 40(10):1199-203 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Yasushi Okazaki
Evaluated 4 Nov 2008

Recommended
F1000 Factor 3.0

Hypothesis
New Finding
 Toward predicting self-splicing and protein-facilitated splicing of group I introns.
Vicens Q, Paukstelis PJ, …, Lambowitz AM, Cech TR
RNA 2008 Oct 14(10):2013-29 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Niles Lehman with Aaron S. Burton
Evaluated 30 Oct 2008

Recommended
F1000 Factor 3.0

Tech Advance
 Exalign: a new method for comparative analysis of exon-intron gene structures.
Pavesi G, Zambelli F, Caggese C, Pesole G
Nucleic Acids Res 2008 May 36:e47 [full text]
Selected by | Andras Fiser
Evaluated 28 Oct 2008

Recommended
F1000 Factor 3.0

Hypothesis
Tech Advance
 Dealing with incongruence in phylogenomic analyses.
Galtier N, Daubin V
Philos Trans R Soc Lond B Biol Sci 2008 Oct 7 [abstract on PubMed] [related articles] [full text]
Selected by | Nicola Mulder
Evaluated 28 Oct 2008

Must Read
F1000 Factor 6.0

New Finding
Tech Advance
Controversial
 Integrated detection and population-genetic analysis of SNPs and copy number variation.
McCarroll SA, Kuruvilla FG, …, Gabriel SB, Altshuler D
Nat Genet 2008 Oct 40(10):1166-74 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Andrew Wilkie
Evaluated 24 Oct 2008


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