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F1000 Factor 3.0

New Finding
Tech Advance
 HLA-DRB1*0401 and HLA-DRB1*0408 are strongly associated with the development of antibodies against interferon-beta therapy in multiple sclerosis.
Hoffmann S, Cepok S, …, Wasmuth R, Hemmer B
Am J Hum Genet 2008 Aug 83(2):219-27 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Murali Ramanathan
Evaluated 27 Aug 2008

Must Read
F1000 Factor 6.0

New Finding
 The parasexual cycle in Candida albicans provides an alternative pathway to meiosis for the formation of recombinant strains.
Forche A, Alby K, …, Berman J, Bennett RJ
PLoS Biol 2008 May 6 6(5):e110 [abstract on PubMed] [related articles] [FREE full text]
Selected by | John Logsdon
Evaluated 27 Aug 2008

Must Read
F1000 Factor 6.0

Tech Advance
 Alta-Cyclic: a self-optimizing base caller for next-generation sequencing.
Erlich Y, Mitra PP, …, McCombie WR, Hannon GJ
Nat Methods 2008 Aug 5(8):679-82 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Pui-Yan Kwok
Evaluated 27 Aug 2008

Exceptional
F1000 Factor 9.0

Hypothesis
Controversial
 A brief history of the hypothesis.
Glass DJ, Hall N
Cell 2008 Aug 8 134(3):378-81 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Ram Samudrala with Jeremy Horst
Evaluated 22 Aug 2008

Recommended
F1000 Factor 3.0

Tech Advance
 Caenorhabditis elegans mutant allele identification by whole-genome sequencing.
Sarin S, Prabhu S, …, Pe'er I, Hobert O
Nat Methods 2008 Aug 1 [abstract on PubMed] [related articles] [full text]
Selected by | Bob Goldstein
Evaluated 22 Aug 2008

Recommended
F1000 Factor 3.0

Hypothesis
New Finding
 Regional variation in the density of essential genes in mice.
Hentges KE, Pollock DD, Liu B, Justice MJ
PLoS Genet 2007 May 4 3(5):e72 [abstract on PubMed] [related articles] [FREE full text]
Selected by | William L Stanford
Evaluated 21 Aug 2008

Recommended
F1000 Factor 3.0

New Finding
 Human and chimpanzee gene expression differences replicated in mice fed different diets.
Somel M, Creely H, …, Khaitovich P, Pääbo S
PLoS ONE 2008 3(1):e1504 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Seth J Davis
Evaluated 15 Aug 2008

Must Read
F1000 Factor 6.0

New Finding
Tech Advance
 Manipulating the metazoan mitochondrial genome with targeted restriction enzymes.
Xu H, DeLuca SZ, O'Farrell PH
Science 2008 Jul 25 321(5888):575-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Rand
Evaluated 15 Aug 2008

Recommended
F1000 Factor 3.0

New Finding
Novel Drug Target
 Position-dependent function for a tandem microRNA miR-122-binding site located in the hepatitis C virus RNA genome.
Jopling CL, Schütz S, Sarnow P
Cell Host Microbe 2008 Jul 17 4(1):77-85 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Lynne Maquat with Olaf Isken
Evaluated 15 Aug 2008

Must Read
F1000 Factor 6.0

Tech Advance
 Polymorphism Interaction Analysis (PIA): a method for investigating complex gene-gene interactions.
Mechanic LE, Luke BT, …, Chanock SJ, Harris CC
BMC Bioinformatics 2008 9:146 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Marylyn Ritchie
Evaluated 14 Aug 2008


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