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Tech Advance
 The transition from differential equations to Boolean networks: a case study in simplifying a regulatory network model.
Davidich M, Bornholdt S
J Theor Biol 2008 Dec 7 255(3):269-77 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Philip Maini
Evaluated 19 Nov 2008

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F1000 Factor 3.0

Confirmation
New Finding
 PPAR{gamma} and C/EBP factors orchestrate adipocyte biology via adjacent binding on a genome-wide scale.
Lefterova MI, Zhang Y, …, Liu XS, Lazar MA
Genes Dev 2008 Nov 1 22(21):2941-52 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Andrew D. Sharrocks
Evaluated 18 Nov 2008

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Hypothesis
New Finding
 Reinforcement of cell junctions correlates with the absence of hair cell regeneration in mammals and its occurrence in birds.
Burns J, Christophel JJ, …, Carfrae M, Corwin JT
J Comp Neurol 2008 Nov 20 511(3):396-414 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Andy Groves
Evaluated 17 Nov 2008

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New Finding
Novel Drug Target
 The succinate receptor GPR91 in neurons has a major role in retinal angiogenesis.
Sapieha P, Sirinyan M, …, Sennlaub F, Chemtob S
Nat Med 2008 Oct 14(10):1067-76 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Raymond Harris
Evaluated 17 Nov 2008

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F1000 Factor 3.0

New Finding
 TAp73 knockout shows genomic instability with infertility and tumor suppressor functions.
Tomasini R, Tsuchihara K, …, Jurisicova A, Mak TW
Genes Dev 2008 Oct 1 22(19):2677-91 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Rong Li with Giulia Rancati
Evaluated 12 Nov 2008

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F1000 Factor 3.0

New Finding
 The Target of Rapamycin pathway antagonizes pha-4/FoxA to control development and aging.
Sheaffer KL, Updike DL, Mango SE
Curr Biol 2008 Sep 23 18(18):1355-64 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Christopher Proud
Evaluated 12 Nov 2008

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F1000 Factor 3.0

New Finding
 Self-renewal and expansion of single transplanted muscle stem cells.
Sacco A, Doyonnas R, …, Vitorovic S, Blau HM
Nature 2008 Sep 17 [abstract on PubMed] [related articles] [full text]
Selected by | Carlo Reggiani with Marco Quarta
Evaluated 11 Nov 2008


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F1000 Factor 3.0

Confirmation
New Finding
 Meiotic inactivation of Xenopus Myt1 by CDK/XRINGO, but not CDK/cyclin, via site-specific phosphorylation.
Ruiz EJ, Hunt T, Nebreda AR
Mol Cell 2008 Oct 24 32(2):210-20 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Robert Fisher with Karl Merrick
Evaluated 11 Nov 2008

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New Finding
 The microRNA miR-8 is a conserved negative regulator of Wnt signaling.
Kennell JA, Gerin I, MacDougald OA, Cadigan KM
Proc Natl Acad Sci U S A 2008 Oct 7 105(40):15417-22 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Rik Korswagen
Evaluated 11 Nov 2008

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F1000 Factor 6.0

Hypothesis
New Finding
Tech Advance
 Interaction between Reelin and Notch signaling regulates neuronal migration in the cerebral cortex.
Hashimoto-Torii K, Torii M, …, Sestan N, Rakic P
Neuron 2008 Oct 23 60(2):273-84 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Orly Reiner
Evaluated 11 Nov 2008


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