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F1000 Factor 3.0

New Finding
 Temporal requirement of the alternative-splicing factor Sfrs1 for the survival of retinal neurons.
Kanadia RN, Clark VE, …, Trimarchi JM, Cepko CL
Development 2008 Dec 135(23):3923-33 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Reinhard Luehrmann
Evaluated 20 Nov 2008

Must Read
F1000 Factor 6.0

Hypothesis
New Finding
 Aire controls the differentiation program of thymic epithelial cells in the medulla for the establishment of self-tolerance.
Yano M, Kuroda N, …, Mouri Y, Matsumoto M
J Exp Med 2008 Nov 17 [abstract on PubMed] [related articles] [full text]
Selected by | David Chaplin
Evaluated 19 Nov 2008

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F1000 Factor 3.0

New Finding
 Association between active genes occurs at nuclear speckles and is modulated by chromatin environment.
Brown JM, Green J, …, Iborra FJ, Buckle VJ
J Cell Biol 2008 Sep 22 182(6):1083-97 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Peter Shaw
Evaluated 18 Nov 2008

Must Read
F1000 Factor 6.0

Hypothesis
New Finding
 Glucose induces an autocrine activation of the Wnt/beta-catenin pathway in macrophage cell lines.
Anagnostou SH, Shepherd PR
Biochem J 2008 Dec 1 416(2):211-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Alex Toker
Evaluated 18 Nov 2008

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F1000 Factor 3.0

New Finding
 Persistent epigenetic differences associated with prenatal exposure to famine in humans.
Heijmans BT, Tobi EW, …, Slagboom PE, Lumey LH
Proc Natl Acad Sci U S A 2008 Nov 4 105(44):17046-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Wolf Reik
Evaluated 18 Nov 2008

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F1000 Factor 3.0

New Finding
 Fgf8a induces neural crest indirectly through the activation of Wnt8 in the paraxial mesoderm.
Hong CS, Park BY, Saint-Jeannet JP
Development 2008 Dec 135(23):3903-10 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Chaya Kalcheim
Evaluated 17 Nov 2008

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F1000 Factor 6.0

Hypothesis
New Finding
 Polycomb proteins targeted by a short repeat RNA to the mouse X chromosome.
Zhao J, Sun BK, …, Song JJ, Lee JT
Science 2008 Oct 31 322(5902):750-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Brad Bernstein
Evaluated 17 Nov 2008

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F1000 Factor 3.0

New Finding
 A small molecule enhances RNA interference and promotes microRNA processing.
Shan G, Li Y, …, He C, Jin P
Nat Biotechnol 2008 Aug 26(8):933-40 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Gabriele Varani
Evaluated 14 Nov 2008

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F1000 Factor 6.0

New Finding
Novel Drug Target
 Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease.
Du H, Guo L, …, Chen JX, Yan SD
Nat Med 2008 Oct 14(10):1097-105 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Heinz Osiewacz
Evaluated 14 Nov 2008

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F1000 Factor 3.0

New Finding
 PirB is a functional receptor for myelin inhibitors of axonal regeneration.
Atwal JK, Pinkston-Gosse J, …, Shatz C, Tessier-Lavigne M
Science 2008 Nov 7 322(5903):967-70 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Susan K. McConnell
Evaluated 14 Nov 2008


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