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Must Read
F1000 Factor 6.0

New Finding
Tech Advance
 Molecular Engineering of Photoremovable Protecting Groups for Two-Photon Uncaging.
Gug S, Bolze F, …, Goeldner M, Nicoud JF
Angew Chem Int Ed Engl 2008 Oct 29 [abstract on PubMed] [related articles] [full text]
Selected by | Michael Pirrung
Evaluated 18 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
 Structure-activity relationships study of bastadin 6, an anti-angiogenic brominated-tyrosine derived metabolite from marine sponge.
Kotoku N, Hiramatsu A, …, Aoki S, Kobayashi M
Arch Pharm (Weinheim) 2008 Sep 341(9):568-77 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Tadeusz Molinski
Evaluated 18 Nov 2008

Must Read
F1000 Factor 6.0

Confirmation
Tech Advance
Novel Drug Target
 Design and synthesis of highly sensitive fluorogenic substrates for glutathione S-transferase and application for activity imaging in living cells.
Fujikawa Y, Urano Y, …, Inoue H, Nagano T
J Am Chem Soc 2008 Nov 5 130(44):14533-43 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Hening Lin
Evaluated 17 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
 A small molecule enhances RNA interference and promotes microRNA processing.
Shan G, Li Y, …, He C, Jin P
Nat Biotechnol 2008 Aug 26(8):933-40 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Gabriele Varani
Evaluated 14 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
Tech Advance
 Exploring RNA transcription and turnover in vivo by using click chemistry.
Jao CY, Salic A
Proc Natl Acad Sci U S A 2008 Oct 14 105(41):15779-84 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Michael B. Yaffe
Evaluated 14 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
Tech Advance
 Seleninate in place of phosphate: irreversible inhibition of protein tyrosine phosphatases.
Abdo M, Liu S, …, Knapp S, Zhang ZY
J Am Chem Soc 2008 Oct 8 130(40):13196-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Philip Cole
Evaluated 14 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
Tech Advance
 Substituted 2-Imino-5-arylidenethiazolidin-4-one Inhibitors of Bacterial Type III Secretion.
Kline T, Felise HB, …, Nguyen HV, Miller SI
J Med Chem 2008 Oct 24 0 [abstract on PubMed] [related articles] [full text]
Selected by | Robert Fecik
Evaluated 13 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
Novel Drug Target
 Discovery of 1,4-substituted piperidines as potent and selective inhibitors of T-type calcium channels.
Yang ZQ, Barrow JC, …, Koblan KS, Renger JJ
J Med Chem 2008 Oct 23 51(20):6471-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Triggle
Evaluated 12 Nov 2008

Must Read
F1000 Factor 6.0

Hypothesis
New Finding
Novel Drug Target
 Activation of aldehyde dehydrogenase-2 reduces ischemic damage to the heart.
Chen CH, Budas GR, …, Hurley TD, Mochly-Rosen D
Science 2008 Sep 12 321(5895):1493-5 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Triggle
Evaluated 11 Nov 2008

Must Read
F1000 Factor 6.0

New Finding
 Sequential asymmetric polyketide heterocyclization catalyzed by a single cytochrome P450 monooxygenase (AurH).
Richter ME, Traitcheva N, Knüpfer U, Hertweck C
Angew Chem Int Ed Engl 2008 47(46):8872-5 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Newman
Evaluated 7 Nov 2008


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