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F1000 Factor 3.0

Confirmation
Hypothesis
New Finding
 {alpha}- and {beta}- Monosaccharide Transport in Human Erythrocytes.
Carruthers A, Leitch J
Am J Physiol Cell Physiol 2008 Nov 5 [abstract on PubMed] [related articles] [full text]
Selected by | Richard J Naftalin
Evaluated 18 Nov 2008

Recommended
F1000 Factor 3.0

Tech Advance
Novel Drug Target
 Generating Arrays with High Content and Minimal Consumption of Functional Membrane Proteins.
Majd S, Mayer M
J Am Chem Soc 2008 Nov 1 0 [abstract on PubMed] [related articles] [full text]
Selected by | Ross Weatherman
Evaluated 17 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
Tech Advance
 Seleninate in place of phosphate: irreversible inhibition of protein tyrosine phosphatases.
Abdo M, Liu S, …, Knapp S, Zhang ZY
J Am Chem Soc 2008 Oct 8 130(40):13196-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Philip Cole
Evaluated 14 Nov 2008

Must Read
F1000 Factor 6.0

New Finding
 X-ray structure of NS1 from a highly pathogenic H5N1 influenza virus.
Bornholdt ZA, Prasad BV
Nature 2008 Nov 5 [abstract on PubMed] [related articles] [full text]
Selected by | Samuel Butcher
Evaluated 13 Nov 2008

Must Read
F1000 Factor 6.0

Hypothesis
Refutation
Novel Drug Target
 Anionic charge is prioritized over geometry in aluminum and magnesium fluoride transition state analogs of phosphoryl transfer enzymes.
Baxter NJ, Blackburn GM, …, Wemmer DE, Waltho JP
J Am Chem Soc 2008 Mar 26 130(12):3952-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Arieh Warshel with Shina Caroline Lynn Kamerlin
Evaluated 13 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
 Importance of Direct Interactions with Lipids for the Function of the Mechanosensitive Channel MscL.
Powl AM, East JM, Lee AG
Biochemistry 2008 Oct 25 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Ian Booth
Evaluated 13 Nov 2008

Recommended
F1000 Factor 3.0

Confirmation
Hypothesis
New Finding
 Crystal Structure of a Ten-Amino Acid Protein.
Honda S, Akiba T, …, Odahara T, Harata K
J Am Chem Soc 2008 Oct 25 0 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Torleif Härd
Evaluated 12 Nov 2008

Must Read
F1000 Factor 4.8

New Finding
Tech Advance
 Global protein stability profiling in mammalian cells.
Yen HC, Xu Q, …, Zhao Z, Elledge SJ
Science 2008 Nov 7 322(5903):918-23 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Berl R. Oakley / Hunter Fraser
First evaluation 12 Nov 2008 | Latest evaluation 18 Nov 2008

Must Read
F1000 Factor 6.0

New Finding
Tech Advance
 Single-particle kinetics of influenza virus membrane fusion.
Floyd DL, Ragains JR, …, Harrison SC, van Oijen AM
Proc Natl Acad Sci U S A 2008 Oct 7 105(40):15382-7 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Lukas Tamm with Volker Kiessling
Evaluated 10 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
 Reconstitution of ThiC in thiamine pyrimidine biosynthesis expands the radical SAM superfamily.
Chatterjee A, Li Y, …, Begley TP, Ealick SE
Nat Chem Biol 2008 Oct 26 [abstract on PubMed] [related articles] [full text]
Selected by | Andrea Mattevi
Evaluated 10 Nov 2008


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