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F1000 Factor 3.0

Tech Advance
 Novel genetically encoded biosensors using firefly luciferase.
Fan F, Binkowski BF, …, Lewis MK, Wood KV
ACS Chem Biol 2008 Jun 20 3(6):346-51 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Kai Johnsson
Evaluated 27 Oct 2008

Exceptional
F1000 Factor 9.0

New Finding
Novel Drug Target
 A new class of anthelmintics effective against drug-resistant nematodes.
Kaminsky R, Ducray P, …, Sluder A, Maser P
Nature 2008 Mar 13 452(7184):176-80 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | R. Kip Guy
Evaluated 24 Oct 2008

Must Read
F1000 Factor 6.0

Confirmation
New Finding
 NMR structures of two designed proteins with high sequence identity but different fold and function.
He Y, Chen Y, …, Bryan PN, Orban J
Proc Natl Acad Sci U S A 2008 Sep 23 105(38):14412-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | H Jane Dyson with Gira Bhabha
Evaluated 23 Oct 2008

Recommended
F1000 Factor 3.0

Hypothesis
New Finding
 Mutation analysis in UGT1A9 suggests a relationship between substrate and catalytic residues in UDP-glucuronosyltransferases.
Patana AS, Kurkela M, Finel M, Goldman A
Protein Eng Des Sel 2008 Sep 21(9):537-43 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jon Thorson with Dr. Gavin J. Williams
Evaluated 23 Oct 2008

Recommended
F1000 Factor 3.0

New Finding
Tech Advance
 Directed evolution of streptavidin variants using in vitro compartmentalization.
Levy M, Ellington AD
Chem Biol 2008 Sep 22 15(9):979-89 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Niles Lehman
Evaluated 23 Oct 2008

Recommended
F1000 Factor 3.0

Hypothesis
New Finding
Tech Advance
 Revealing the catalytic potential of an acyl-ACP desaturase: tandem selective oxidation of saturated fatty acids.
Whittle EJ, Tremblay AE, Buist PH, Shanklin J
Proc Natl Acad Sci U S A 2008 Sep 23 105(38):14738-43 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Barry Stoddard
Evaluated 17 Oct 2008

Must Read
F1000 Factor 6.0

New Finding
Tech Advance
 Directed evolution of a G protein-coupled receptor for expression, stability, and binding selectivity.
Sarkar CA, Dodevski I, …, Hermans E, Plückthun A
Proc Natl Acad Sci U S A 2008 Sep 30 105(39):14808-13 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Nathan Nelson with Alexey Amunts
Evaluated 17 Oct 2008

Recommended
F1000 Factor 3.0

Hypothesis
New Finding
Tech Advance
 Ribonuclease A homologues of the zebrafish: polymorphism, crystal structures of two representatives and their evolutionary implications.
Kazakou K, Holloway DE, …, Subramanian V, Acharya KR
J Mol Biol 2008 Jun 27 380(1):206-22 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Helene Rosenberg
Evaluated 13 Oct 2008

Recommended
F1000 Factor 3.0

Hypothesis
New Finding
Refutation
 Kinetics and thermodynamics of ligand binding to a molten globular enzyme and its native counterpart.
Vamvaca K, Jelesarov I, Hilvert D
J Mol Biol 2008 Oct 17 382(4):971-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Herschel Wade
Evaluated 7 Oct 2008

Must Read
F1000 Factor 6.0

Confirmation
Tech Advance
 Selecting aptamers for a glycoprotein through the incorporation of the boronic acid moiety.
Li M, Lin N, …, Fang H, Wang B
J Am Chem Soc 2008 Sep 24 130(38):12636-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Dennis Hall
Evaluated 6 Oct 2008


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