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F1000 Factor 3.0

New Finding
 Adenosyltransferase tailors and delivers coenzyme B12.
Padovani D, Labunska T, …, Ballou DP, Banerjee R
Nat Chem Biol 2008 Mar 4(3):194-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Joan Broderick with Tilak Chandra
Evaluated 18 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
Controversial
 The transcriptional repressor protein NsrR senses nitric oxide directly via a [2Fe-2S] cluster.
Tucker NP, Hicks MG, …, Dixon R, Hutchings MI
PLoS ONE 2008 3(11):e3623 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Stephen Spiro
Evaluated 18 Nov 2008

Must Read
F1000 Factor 6.0

Hypothesis
Refutation
Novel Drug Target
 Anionic charge is prioritized over geometry in aluminum and magnesium fluoride transition state analogs of phosphoryl transfer enzymes.
Baxter NJ, Blackburn GM, …, Wemmer DE, Waltho JP
J Am Chem Soc 2008 Mar 26 130(12):3952-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Arieh Warshel with Shina Caroline Lynn Kamerlin
Evaluated 13 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
 Reconstitution of ThiC in thiamine pyrimidine biosynthesis expands the radical SAM superfamily.
Chatterjee A, Li Y, …, Begley TP, Ealick SE
Nat Chem Biol 2008 Oct 26 [abstract on PubMed] [related articles] [full text]
Selected by | Andrea Mattevi
Evaluated 10 Nov 2008

Must Read
F1000 Factor 6.0

Tech Advance
Novel Drug Target
 The potential of desferrioxamine-gallium as an anti-Pseudomonas therapeutic agent.
Banin E, Lozinski A, …, Greenberg EP, Banin E
Proc Natl Acad Sci U S A 2008 Oct 28 105(43):16761-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Kim Lewis with Lawrence R. Mulcahy
Evaluated 10 Nov 2008

Exceptional
F1000 Factor 9.0

New Finding
 Merging photoredox catalysis with organocatalysis: the direct asymmetric alkylation of aldehydes.
Nicewicz DA, MacMillan DW
Science 2008 Oct 3 322(5898):77-80 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Wolfgang Buckel
Evaluated 7 Nov 2008

Must Read
F1000 Factor 6.0

New Finding
 Arrestin-like proteins mediate ubiquitination and endocytosis of the yeast metal transporter Smf1.
Nikko E, Sullivan JA, Pelham HR
EMBO Rep 2008 Oct 24 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Sharad Kumar
Evaluated 7 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
 Functional characterization and metal ion specificity of the metal-citrate complex transporter from Streptomyces coelicolor.
Lensbouer JJ, Patel A, Sirianni JP, Doyle RP
J Bacteriol 2008 Aug 190(16):5616-23 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jon Zubieta
Evaluated 6 Nov 2008

Must Read
F1000 Factor 6.0

New Finding
 The nodule inception-like protein 7 modulates nitrate sensing and metabolism in Arabidopsis.
Castaings L, Camargo A, …, Meyer C, Krapp A
Plant J 2008 Sep 26 [abstract on PubMed] [related articles] [full text]
Selected by | Joseph Strauss
Evaluated 6 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
 A putative Fe2+-bound persulfenate intermediate in cysteine dioxygenase.
Simmons CR, Krishnamoorthy K, …, Stipanuk MH, Karplus PA
Biochemistry 2008 Nov 4 47(44):11390-2 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Ruma Banerjee
Evaluated 6 Nov 2008


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