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F1000 Factor 3.0

Confirmation
Hypothesis
New Finding
 {alpha}- and {beta}- Monosaccharide Transport in Human Erythrocytes.
Carruthers A, Leitch J
Am J Physiol Cell Physiol 2008 Nov 5 [abstract on PubMed] [related articles] [full text]
Selected by | Richard J Naftalin
Evaluated 18 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
 Adenosyltransferase tailors and delivers coenzyme B12.
Padovani D, Labunska T, …, Ballou DP, Banerjee R
Nat Chem Biol 2008 Mar 4(3):194-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Joan Broderick with Tilak Chandra
Evaluated 18 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
Tech Advance
 Seleninate in place of phosphate: irreversible inhibition of protein tyrosine phosphatases.
Abdo M, Liu S, …, Knapp S, Zhang ZY
J Am Chem Soc 2008 Oct 8 130(40):13196-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Philip Cole
Evaluated 14 Nov 2008

Must Read
F1000 Factor 6.0

Hypothesis
Refutation
Novel Drug Target
 Anionic charge is prioritized over geometry in aluminum and magnesium fluoride transition state analogs of phosphoryl transfer enzymes.
Baxter NJ, Blackburn GM, …, Wemmer DE, Waltho JP
J Am Chem Soc 2008 Mar 26 130(12):3952-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Arieh Warshel with Shina Caroline Lynn Kamerlin
Evaluated 13 Nov 2008

Must Read
F1000 Factor 6.6

Hypothesis
New Finding
 HARP is an ATP-driven annealing helicase.
Yusufzai T, Kadonaga JT
Science 2008 Oct 31 322(5902):748-50 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Michael Botchan / Lucio Comai / Jessica Downs
First evaluation 13 Nov 2008 | Latest evaluation 17 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
Novel Drug Target
 Alternate mRNA splicing in multiple human tryptase genes is predicted to regulate tetramer formation.
Jackson NE, Wang HW, …, Cairns J, Hunt JE
J Biol Chem 2008 Oct 14 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Richard L. Stevens
Evaluated 13 Nov 2008

Must Read
F1000 Factor 6.0

Hypothesis
New Finding
Novel Drug Target
 Activation of aldehyde dehydrogenase-2 reduces ischemic damage to the heart.
Chen CH, Budas GR, …, Hurley TD, Mochly-Rosen D
Science 2008 Sep 12 321(5895):1493-5 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Triggle
Evaluated 11 Nov 2008

Recommended
F1000 Factor 3.0

Hypothesis
New Finding
 Mutations of RNA polymerase II activate key genes of the nucleoside triphosphate biosynthetic pathways.
Kwapisz M, Wery M, …, Thuriaux P, Lacroute F
EMBO J 2008 Sep 17 27(18):2411-21 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Jesper Svejstrup with Ozan Aygun
Evaluated 11 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
 Reconstitution of ThiC in thiamine pyrimidine biosynthesis expands the radical SAM superfamily.
Chatterjee A, Li Y, …, Begley TP, Ealick SE
Nat Chem Biol 2008 Oct 26 [abstract on PubMed] [related articles] [full text]
Selected by | Andrea Mattevi
Evaluated 10 Nov 2008

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F1000 Factor 3.0

New Finding
Novel Drug Target
 Modulation of the anti-nociceptive effects of 2-arachidonoyl glycerol by peripherally administered FAAH and MGL inhibitors in a neuropathic pain model.
Desroches J, Guindon J, Lambert C, Beaulieu P
Br J Pharmacol 2008 Aug 11 [abstract on PubMed] [related articles] [full text]
Selected by | Roger Pertwee with Maria-Grazia Cascio
Evaluated 10 Nov 2008


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