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Must Read
F1000 Factor 6.0

New Finding
 Mitochondrial cholesterol contributes to chemotherapy resistance in hepatocellular carcinoma.
Montero J, Morales A, …, Colell A, Fernández-Checa JC
Cancer Res 2008 Jul 1 68(13):5246-56 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Andrews
Evaluated 19 Nov 2008

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F1000 Factor 3.0

Confirmation
Hypothesis
New Finding
 Vaccinia virus anti-apoptotic F1L is a novel Bcl-2-like domain-swapped dimer that binds a highly selective subset of BH3-containing death ligands.
Kvansakul M, Yang H, …, Huang DC, Colman PM
Cell Death Differ 2008 Oct 15(10):1564-71 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Andrews
Evaluated 18 Nov 2008

Must Read
F1000 Factor 6.0

New Finding
Novel Drug Target
 Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease.
Du H, Guo L, …, Chen JX, Yan SD
Nat Med 2008 Oct 14(10):1097-105 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Heinz Osiewacz
Evaluated 14 Nov 2008

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F1000 Factor 6.0

New Finding
Novel Drug Target
 Pharmacological targeting of NF-kappaB potentiates the effect of the topoisomerase inhibitor CPT-11 on colon cancer cells.
Lagadec P, Griessinger E, …, Dreano M, Peyron JF
Br J Cancer 2008 Jan 29 98(2):335-44 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jean Clairambault
Evaluated 14 Nov 2008

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F1000 Factor 3.0

New Finding
Controversial
 Functional targeting of DNA damage to a nuclear pore-associated SUMO-dependent ubiquitin ligase.
Nagai S, Dubrana K, …, Gasser SM, Krogan NJ
Science 2008 Oct 24 322(5901):597-602 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Steven Brill
Evaluated 12 Nov 2008

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F1000 Factor 3.0

New Finding
 TAp73 knockout shows genomic instability with infertility and tumor suppressor functions.
Tomasini R, Tsuchihara K, …, Jurisicova A, Mak TW
Genes Dev 2008 Oct 1 22(19):2677-91 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Rong Li with Giulia Rancati
Evaluated 12 Nov 2008

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F1000 Factor 3.0

Hypothesis
New Finding
 Transient transcriptional responses to stress are generated by opposing effects of mRNA production and degradation.
Shalem O, Dahan O, …, Segal E, Pilpel Y
Mol Syst Biol 2008 4:223 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Jurg Bahler
Evaluated 12 Nov 2008

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F1000 Factor 3.0

New Finding
 Self-renewal and expansion of single transplanted muscle stem cells.
Sacco A, Doyonnas R, …, Vitorovic S, Blau HM
Nature 2008 Sep 17 [abstract on PubMed] [related articles] [full text]
Selected by | Carlo Reggiani with Marco Quarta
Evaluated 11 Nov 2008


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F1000 Factor 6.0

Hypothesis
New Finding
 Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes.
Song B, Scheuner D, …, Pennathur S, Kaufman RJ
J Clin Invest 2008 Oct 118(10):3378-89 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Raghavendra Mirmira
Evaluated 11 Nov 2008

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F1000 Factor 6.0

New Finding
Novel Drug Target
 Triggering the succinate receptor GPR91 on dendritic cells enhances immunity.
Rubic T, Lametschwandtner G, …, Rot A, Carballido JM
Nat Immunol 2008 Nov 9(11):1261-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Mauro Teixeira
Evaluated 10 Nov 2008


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