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Exceptional
F1000 Factor 9.0

New Finding
Novel Drug Target
 Selective nucleoside triphosphate diphosphohydrolase-2 (NTPDase2) inhibitors: nucleotide mimetics derived from uridine-5'-carboxamide.
Brunschweiger A, Iqbal J, …, Knowles AF, Müller CE
J Med Chem 2008 Aug 14 51(15):4518-28 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Geoffrey Burnstock
Evaluated 6 Oct 2008

Recommended
F1000 Factor 3.0

Hypothesis
Novel Drug Target
 P2 receptors in atherosclerosis and postangioplasty restenosis.
Seye CI, Kong Q, …, Erb L, Weisman GA
Purinergic Signal 2007 Mar 3(1-2):153-62 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Geoffrey Burnstock
Evaluated 3 Oct 2008

Recommended
F1000 Factor 3.0

New Finding
 Inflammatory cytokines induce phosphorylation and ubiquitination of prostate suppressor protein NKX3.1.
Markowski MC, Bowen C, Gelmann EP
Cancer Res 2008 Sep 1 68(17):6896-901 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Simon Hayward
Evaluated 3 Oct 2008

Must Read
F1000 Factor 6.0

Hypothesis
 Microtubules do not promote mitotic slippage when the spindle assembly checkpoint cannot be satisfied.
Brito DA, Yang Z, Rieder CL
J Cell Biol 2008 Aug 25 182(4):623-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Michele Pagano
Evaluated 3 Oct 2008

Recommended
F1000 Factor 3.0

New Finding
 The detergent resistance of Connexin43 is lost upon TPA or EGF treatment and is an early step in gap junction endocytosis.
Sirnes S, Leithe E, Rivedal E
Biochem Biophys Res Commun 2008 Sep 5 373(4):597-601 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Chloe Bulinski
Evaluated 3 Oct 2008

Must Read
F1000 Factor 6.0

Hypothesis
New Finding
Tech Advance
 The Hsk1/Cdc7 Replication Kinase Regulates Origin Efficiency.
Patel PK, Kommajosyula N, …, Bechhoefer J, Rhind N
Mol Biol Cell 2008 Sep 17 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Joel Huberman
Evaluated 2 Oct 2008

Must Read
F1000 Factor 6.0

Hypothesis
New Finding
 CRAF Autophosphorylation of Serine 621 Is Required to Prevent Its Proteasome-Mediated Degradation.
Noble C, Mercer K, …, Marais R, Pritchard CA
Mol Cell 2008 31:862-872 [full text]
Selected by | Simon Cook
Evaluated 1 Oct 2008

Must Read
F1000 Factor 6.0

New Finding
 Acetylation of histone H3 lysine 56 regulates replication-coupled nucleosome assembly.
Li Q, Zhou H, …, Verreault A, Zhang Z
Cell 2008 Jul 25 134(2):244-55 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Philippe Pasero with Laure Crabbe
Evaluated 1 Oct 2008

Must Read
F1000 Factor 6.0

New Finding
Novel Drug Target
 cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination.
Bertrand MJ, Milutinovic S, …, Morris SJ, Barker PA
Mol Cell 2008 Jun 20 30(6):689-700 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Hao Wu with Steven M. Damo
Evaluated 1 Oct 2008

Recommended
F1000 Factor 3.0

New Finding
 Human squamous cell carcinomas evade the immune response by down-regulation of vascular E-selectin and recruitment of regulatory T cells.
Clark RA, Huang SJ, …, Lambert J, Kupper TS
J Exp Med 2008 Sep 15 [abstract on PubMed] [related articles] [full text]
Selected by | Mark Smyth
Evaluated 30 Sep 2008


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