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Must Read
F1000 Factor 6.0

New Finding
Mitochondrial cholesterol contributes to chemotherapy resistance in hepatocellular carcinoma.
Montero J, Morales A, …, Colell A, Fernández-Checa JC
Cancer Res 2008 Jul 1 68(13):5246-56 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Andrews
Evaluated 19 Nov 2008

Recommended
F1000 Factor 3.0

Confirmation
Hypothesis
New Finding
{alpha}- and {beta}- Monosaccharide Transport in Human Erythrocytes.
Carruthers A, Leitch J
Am J Physiol Cell Physiol 2008 Nov 5 [abstract on PubMed] [related articles] [full text]
Selected by | Richard J Naftalin
Evaluated 18 Nov 2008

Must Read
F1000 Factor 6.0

New Finding
Gerodermia osteodysplastica is caused by mutations in SCYL1BP1, a Rab-6 interacting golgin.
Hennies HC, Kornak U, …, Wieacker P, Mundlos S
Nat Genet 2008 Nov 9 [abstract on PubMed] [related articles] [full text]
Selected by | Peter McPherson
Evaluated 18 Nov 2008

Recommended
F1000 Factor 3.0

Tech Advance
Novel Drug Target
Generating Arrays with High Content and Minimal Consumption of Functional Membrane Proteins.
Majd S, Mayer M
J Am Chem Soc 2008 Nov 1 0 [abstract on PubMed] [related articles] [full text]
Selected by | Ross Weatherman
Evaluated 17 Nov 2008

Recommended
F1000 Factor 3.0

Confirmation
Paracrine regulation of the epithelial Na+ channel in the mammalian collecting duct by purinergic P2Y2 receptor tone.
Pochynyuk O, Bugaj V, …, Vallon V, Stockand JD
J Biol Chem 2008 Nov 3 [abstract on PubMed] [related articles] [FREE full text]
Selected by | William Welch
Evaluated 17 Nov 2008

Must Read
F1000 Factor 6.0

New Finding
Novel Drug Target
Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease.
Du H, Guo L, …, Chen JX, Yan SD
Nat Med 2008 Oct 14(10):1097-105 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Heinz Osiewacz
Evaluated 14 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
Importance of Direct Interactions with Lipids for the Function of the Mechanosensitive Channel MscL.
Powl AM, East JM, Lee AG
Biochemistry 2008 Oct 25 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Ian Booth
Evaluated 13 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
Efficient termination of vacuolar Rab GTPase signaling requires coordinated action by a GAP and a protein kinase.
Brett CL, Plemel RL, …, Fields S, Merz AJ
J Cell Biol 2008 Sep 22 182(6):1141-51 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Elizabeth Smythe
Evaluated 13 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
Regulation of retromer recruitment to endosomes by sequential action of Rab5 and Rab7.
Rojas R, van Vlijmen T, …, van der Sluijs P, Bonifacino JS
J Cell Biol 2008 Nov 3 183(3):513-26 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Michael Roth
Evaluated 12 Nov 2008

Must Read
F1000 Factor 6.0

Confirmation
New Finding
On the spontaneous emergence of cell polarity.
Altschuler SJ, Angenent SB, Wang Y, Wu LF
Nature 2008 Aug 14 454(7206):886-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Carlos Dotti
Evaluated 11 Nov 2008


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