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Must Read
F1000 Factor 6.0

Confirmation
Hypothesis
Genome-wide linkage analysis of multiple measures of neuroticism of 2 large cohorts from Australia and the Netherlands.
Wray NR, Middeldorp CM, …, Martin NG, Boomsma DI
Arch Gen Psychiatry 2008 Jun 65(6):649-58 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Ian Deary with Lorna Houlihan
Evaluated 18 Nov 2008

Recommended
F1000 Factor 3.0

Hypothesis
Intestinal gluconeogenesis is a key factor for early metabolic changes after gastric bypass but not after gastric lap-band in mice.
Troy S, Soty M, …, Mithieux G, Andreelli F
Cell Metab 2008 Sep 8(3):201-11 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Joel Elmquist with Kevin W. Williams
Evaluated 18 Nov 2008

Must Read
F1000 Factor 6.0

New Finding
Gerodermia osteodysplastica is caused by mutations in SCYL1BP1, a Rab-6 interacting golgin.
Hennies HC, Kornak U, …, Wieacker P, Mundlos S
Nat Genet 2008 Nov 9 [abstract on PubMed] [related articles] [full text]
Selected by | Peter McPherson
Evaluated 18 Nov 2008

Must Read
F1000 Factor 6.0

Confirmation
Hypothesis
New Finding
Novel Drug Target
Drug-dependent requirement of hippocampal neurogenesis in a model of depression and of antidepressant reversal.
Surget A, Saxe M, …, Hen R, Belzung C
Biol Psychiatry 2008 Aug 15 64(4):293-301 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Esther Sternberg with Marni Silverman
Evaluated 17 Nov 2008

Must Read
F1000 Factor 6.0

New Finding
Ketamine-induced loss of phenotype of fast-spiking interneurons is mediated by NADPH-oxidase.
Behrens MM, Ali SS, …, Quick KL, Dugan LL
Science 2007 Dec 7 318(5856):1645-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Emery Brown
Evaluated 17 Nov 2008


Must Read
F1000 Factor 6.0

New Finding
Novel Drug Target
Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease.
Du H, Guo L, …, Chen JX, Yan SD
Nat Med 2008 Oct 14(10):1097-105 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Heinz Osiewacz
Evaluated 14 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
PirB is a functional receptor for myelin inhibitors of axonal regeneration.
Atwal JK, Pinkston-Gosse J, …, Shatz C, Tessier-Lavigne M
Science 2008 Nov 7 322(5903):967-70 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Susan K. McConnell
Evaluated 14 Nov 2008

Recommended
F1000 Factor 3.0

Hypothesis
Controversial
Novel Drug Target
Impaired parasympathetic function increases susceptibility to inflammatory bowel disease in a mouse model of depression.
Ghia JE, Blennerhassett P, Collins SM
J Clin Invest 2008 Jun 118(6):2209-18 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Ruud Buijs
Evaluated 14 Nov 2008

Exceptional
F1000 Factor 9.0

New Finding
Controversial
Refutation
Increased cognitive functioning in symptomatic Huntington's disease as revealed by behavioral and event-related potential indices of auditory sensory memory and attention.
Beste C, Saft C, Güntürkün O, Falkenstein M
J Neurosci 2008 Nov 5 28(45):11695-702 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jerry Buccafusco
Evaluated 12 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
Disruption of neurofascin and gliomedin at nodes of Ranvier precedes demyelination in experimental allergic neuritis.
Lonigro A, Devaux JJ
Brain 2008 Oct 25 [abstract on PubMed] [related articles] [full text]
Selected by | Elior Peles
Evaluated 11 Nov 2008


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