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Must Read
F1000 Factor 6.0

Hypothesis
New Finding
 Glucose induces an autocrine activation of the Wnt/beta-catenin pathway in macrophage cell lines.
Anagnostou SH, Shepherd PR
Biochem J 2008 Dec 1 416(2):211-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Alex Toker
Evaluated 18 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
 Fgf8a induces neural crest indirectly through the activation of Wnt8 in the paraxial mesoderm.
Hong CS, Park BY, Saint-Jeannet JP
Development 2008 Dec 135(23):3903-10 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Chaya Kalcheim
Evaluated 17 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
Novel Drug Target
 The succinate receptor GPR91 in neurons has a major role in retinal angiogenesis.
Sapieha P, Sirinyan M, …, Sennlaub F, Chemtob S
Nat Med 2008 Oct 14(10):1067-76 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Raymond Harris
Evaluated 17 Nov 2008

Must Read
F1000 Factor 6.0

New Finding
 Familial pulmonary alveolar proteinosis caused by mutations in CSF2RA.
Suzuki T, Sakagami T, …, van der Loo JC, Trapnell BC
J Exp Med 2008 Oct 27 [abstract on PubMed] [related articles] [full text]
Selected by | Glenn Dranoff
Evaluated 17 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
 PirB is a functional receptor for myelin inhibitors of axonal regeneration.
Atwal JK, Pinkston-Gosse J, …, Shatz C, Tessier-Lavigne M
Science 2008 Nov 7 322(5903):967-70 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Susan K. McConnell
Evaluated 14 Nov 2008

Recommended
F1000 Factor 3.0

Confirmation
 Purinergic receptors and synaptic transmission in enteric neurons.
Ren J, Bertrand PP
Purinergic Signal 2008 Sep 4(3):255-66 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Geoffrey Burnstock
Evaluated 14 Nov 2008

Must Read
F1000 Factor 6.0

New Finding
Tech Advance
 Anatomical profiling of G protein-coupled receptor expression.
Regard JB, Sato IT, Coughlin SR
Cell 2008 Oct 31 135(3):561-71 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Soeren Sheikh
Evaluated 14 Nov 2008

Must Read
F1000 Factor 6.0

New Finding
Novel Drug Target
 Pharmacological targeting of NF-kappaB potentiates the effect of the topoisomerase inhibitor CPT-11 on colon cancer cells.
Lagadec P, Griessinger E, …, Dreano M, Peyron JF
Br J Cancer 2008 Jan 29 98(2):335-44 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jean Clairambault
Evaluated 14 Nov 2008

Recommended
F1000 Factor 3.0

Hypothesis
New Finding
 Agonist-selective, Receptor-specific Interaction of Human P2Y Receptors with {beta}-Arrestin-1 and -2.
Hoffmann C, Ziegler N, …, Krasel C, Lohse MJ
J Biol Chem 2008 Nov 7 283(45):30933-41 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Ralf Jockers with Maud Kamal
Evaluated 13 Nov 2008

Recommended
F1000 Factor 3.0

Hypothesis
New Finding
 Human basophils and eosinophils are the direct target leukocytes of the novel IL-1-family member IL-33.
Pecaric-Petkovic T, Didichenko SA, …, Spiegl N, Dahinden CA
Blood 2008 Oct 27 [abstract on PubMed] [related articles] [full text]
Selected by | Marc Rothenberg with Ariel Munitz
Evaluated 13 Nov 2008


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