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Recommended
F1000 Factor 3.0

New Finding
 A role for tumour necrosis factor-alpha, complement C5 and interleukin-6 in the initiation and development of the mycobacterial cord factor trehalose 6,6'-dimycolate induced granulomatous response.
Welsh KJ, Abbott AN, …, Hunter RL, Actor JK
Microbiology 2008 Jun 154(Pt 6):1813-24 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | John Atkinson
Evaluated 26 Aug 2008

Recommended
F1000 Factor 3.0

Hypothesis
New Finding
 Sex differences in the perceived intensity of breathlessness during exercise with advancing age.
Ofir D, Laveneziana P, …, Lam YM, O'Donnell DE
J Appl Physiol 2008 Jun 104(6):1583-93 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Craig Harms
Evaluated 26 Aug 2008

Must Read
F1000 Factor 6.0

New Finding
Tech Advance
 Release of ATP and glutamate in the nucleus tractus solitarii mediate pulmonary stretch receptor (Breuer-Hering) reflex pathway.
Gourine AV, Dale N, …, Huckstepp R, Spyer KM
J Physiol 2008 Jul 10 586 [abstract on PubMed] [related articles] [FREE full text]
Selected by | James Duffin
Evaluated 22 Aug 2008

Recommended
F1000 Factor 3.0

Confirmation
Tech Advance
Novel Drug Target
 Mathematical model of nucleotide regulation on airway epithelia: Implications for airway homeostasis.
Zuo P, Picher M, …, Boucher RC, Elston TC
J Biol Chem 2008 Jul 28 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Merryn Tawhai
Evaluated 18 Aug 2008

Must Read
F1000 Factor 6.0

Confirmation
New Finding
Novel Drug Target
 Theophylline restores histone deacetylase activity and steroid responses in COPD macrophages.
Cosio BG, Tsaprouni L, …, Adcock IM, Barnes PJ
J Exp Med 2004 Sep 6 200(5):689-95 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Peter Jeffery
Evaluated 15 Aug 2008

Recommended
F1000 Factor 3.0

New Finding
Novel Drug Target
 Accumulation of dendritic cells and increased CCL20 levels in the airways of patients with chronic obstructive pulmonary disease.
Demedts IK, Bracke KR, …, Joos GF, Brusselle GG
Am J Respir Crit Care Med 2007 May 15 175(10):998-1005 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Peter Jeffery
Evaluated 15 Aug 2008

Must Read
F1000 Factor 6.0

Hypothesis
New Finding
 Measles virus blind to its epithelial cell receptor remains virulent in rhesus monkeys but cannot cross the airway epithelium and is not shed.
Leonard VH, Sinn PL, …, McChesney MB, Cattaneo R
J Clin Invest 2008 Jul 118(7):2448-58 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Barney Graham
Evaluated 13 Aug 2008

Recommended
F1000 Factor 3.0

Hypothesis
 Minimal volume regulation after shrinkage of red blood cells from five species of reptiles.
Kristensen K, Berenbrink M, …, Abe A, Wang T
Comp Biochem Physiol A Mol Integr Physiol 2008 May 150(1):46-51 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | James Hicks
Evaluated 29 Jul 2008

Recommended
F1000 Factor 3.0

Confirmation
Controversial
 Vertical gradients in regional lung density and perfusion in the supine human lung: the Slinky effect.
Hopkins SR, Henderson AC, …, Buxton RB, Prisk GK
J Appl Physiol 2007 Jul 103(1):240-8 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Thomas Robertson
Evaluated 24 Jul 2008

Must Read
F1000 Factor 6.0

New Finding
 Detection of Mutations in EGFR in Circulating Lung-Cancer Cells.
Maheswaran S, Sequist LV, …, Toner M, Haber DA
N Engl J Med 2008 Jul 2 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Peter Kuhn with Dena Marrinucci
Evaluated 23 Jul 2008



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