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Exceptional
F1000 Factor 9.0

Hypothesis
New Finding
Tech Advance
Novel Drug Target
 Bacterial peptidoglycan triggers Candida albicans hyphal growth by directly activating the adenylyl cyclase Cyr1p.
Xu XL, Lee RT, …, Zhu Y, Wang Y
Cell Host Microbe 2008 Jul 17 4(1):28-39 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Joe Heitman
Evaluated 4 Sep 2008

Must Read
F1000 Factor 6.0

Hypothesis
New Finding
 Gliadin induces an increase in intestinal permeability and zonulin release by binding to the chemokine receptor CXCR3.
Lammers KM, Lu R, …, Vogel SN, Fasano A
Gastroenterology 2008 Jul 135(1):194-204.e3 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Marc Rothenberg
Evaluated 4 Sep 2008

Must Read
F1000 Factor 6.0

New Finding
 TRPP2 and TRPV4 form a polymodal sensory channel complex.
Köttgen M, Buchholz B, …, Kuehn EW, Walz G
J Cell Biol 2008 Aug 11 182(3):437-47 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jens Leipziger with Helle A. Praetorius
Evaluated 4 Sep 2008

Recommended
F1000 Factor 3.0

Confirmation
New Finding
 Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease.
McCarroll SA, Huett A, …, Daly MJ, Xavier RJ
Nat Genet 2008 Aug 24 40 [abstract on PubMed] [related articles] [full text]
Selected by | Vojo Deretic with Isabelle Vergne
Evaluated 4 Sep 2008

Must Read
F1000 Factor 4.8

Hypothesis
New Finding
 The chirality of gut rotation derives from left-right asymmetric changes in the architecture of the dorsal mesentery.
Davis NM, Kurpios NA, …, Martin JF, Tabin CJ
Dev Cell 2008 Jul 15(1):134-45 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Patrick Tam / Denis Duboule
First evaluation 1 Sep 2008 | Latest evaluation 2 Sep 2008

Recommended
F1000 Factor 3.0

Hypothesis
New Finding
 Association of methylenetetrahydrofolate reductase gene polymorphisms and sex-specific survival in patients with metastatic colon cancer.
Zhang W, Press OA, …, Lurje G, Lenz HJ
J Clin Oncol 2007 Aug 20 25(24):3726-31 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Eileen Dolan
Evaluated 29 Aug 2008

Exceptional
F1000 Factor 9.0

Hypothesis
New Finding
Novel Drug Target
 UCP2 mediates ghrelin's action on NPY/AgRP neurons by lowering free radicals.
Andrews ZB, Liu ZW, …, Horvath TL, Diano S
Nature 2008 Aug 14 454(7206):846-51 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Aniko Naray-Fejes-Toth
Evaluated 26 Aug 2008

Recommended
F1000 Factor 3.0

New Finding
Controversial
 Direct activation of cytosolic Ca2+ signaling and enzyme secretion by cholecystokinin in human pancreatic acinar cells.
Murphy JA, Criddle DN, …, Petersen OH, Sutton R
Gastroenterology 2008 Aug 135(2):632-41 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Silvana Curci with Matilde Colella
Evaluated 26 Aug 2008

Must Read
F1000 Factor 6.0

Hypothesis
New Finding
 Murine TNF(DeltaARE) Crohn's disease model displays diminished expression of intestinal Ca2+ transporters.
Huybers S, Apostolaki M, …, Bindels RJ, Hoenderop JG
Inflamm Bowel Dis 2008 Jun 14(6):803-11 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Indu Ambudkar
Evaluated 20 Aug 2008

Recommended
F1000 Factor 3.0

New Finding
Refutation
 Effects of dietary polyunsaturated fatty acids on mitochondrial metabolism in mammalian hibernation.
Gerson AR, Brown JC, …, Bernards MA, Staples JF
J Exp Biol 2008 Aug 211(Pt 16):2689-99 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Hannah Carey
Evaluated 20 Aug 2008


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