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Recommended
F1000 Factor 3.0

New Finding
Unprecedented immunosuppressive polyketides from Daldinia eschscholzii, a mantis-associated fungus.
Zhang YL, Ge HM, …, Song YC, Tan RX
Angew Chem Int Ed Engl 2008 47(31):5823-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Dennis Hall
Evaluated 29 Aug 2008

Recommended
F1000 Factor 3.0

Confirmation
New Finding
Smoothelin-B deficiency results in reduced arterial contractility, hypertension, and cardiac hypertrophy in mice.
Rensen SS, Niessen PM, …, De Mey JG, van Eys GJ
Circulation 2008 Aug 19 118(8):828-36 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Giulio Gabbiani
Evaluated 29 Aug 2008

Must Read
F1000 Factor 6.0

Confirmation
Imatinib pharmacokinetics and its correlation with response and safety in chronic-phase chronic myeloid leukemia: a subanalysis of the IRIS study.
Larson RA, Druker BJ, …, Wang Y, IRIS (International Randomized Interferon vs STI571) Study Group
Blood 2008 Apr 15 111(8):4022-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Susan Bates
Evaluated 28 Aug 2008

Recommended
F1000 Factor 3.0

Hypothesis
New Finding
Trough imatinib plasma levels are associated with both cytogenetic and molecular responses to standard-dose imatinib in chronic myeloid leukemia.
Picard S, Titier K, …, Molimard M, Mahon FX
Blood 2007 Apr 15 109(8):3496-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Susan Bates
Evaluated 28 Aug 2008


Recommended
F1000 Factor 3.0

New Finding
Upregulation of matrix metalloproteinase-9 and tissue inhibitors of metalloproteinases in rapid atrial pacing-induced atrial fibrillation.
Chen CL, Huang SK, …, Wen CH, Lin CS
J Mol Cell Cardiol 2008 Jul 23 [abstract on PubMed] [related articles] [full text]
Selected by | Anthony Dart
Evaluated 28 Aug 2008

Exceptional
F1000 Factor 9.0

New Finding
The macromolecular assembly of pathogen-recognition receptors is impelled by serine proteases, via their complement control protein modules.
Le Saux A, Ng PM, …, Ho B, Ding JL
J Mol Biol 2008 Mar 28 377(3):902-13 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | John Atkinson
Evaluated 26 Aug 2008

Recommended
F1000 Factor 3.0

Confirmation
New Finding
Long-term results of carotid stenting versus endarterectomy in high-risk patients.
Gurm HS, Yadav JS, …, Cutlip DE, SAPPHIRE Investigators
N Engl J Med 2008 Apr 10 358(15):1572-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Rafael Beyar
Evaluated 21 Aug 2008


Recommended
F1000 Factor 3.0

Hypothesis
New Finding
Endothelium-derived hyperpolarizing factor in human internal mammary artery is 11,12-epoxyeicosatrienoic acid and causes relaxation by activating smooth muscle BK(Ca) channels.
Archer SL, Gragasin FS, …, Falck JR, Michelakis ED
Circulation 2003 Feb 11 107(5):769-76 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Andreas Deussen
Evaluated 21 Aug 2008

Must Read
F1000 Factor 4.8

New Finding
Tech Advance
A high-throughput screening strategy identifies cardiotonic steroids as alternative splicing modulators.
Stoilov P, Lin CH, …, Nikolic J, Black DL
Proc Natl Acad Sci U S A 2008 Aug 12 105(32):11218-23 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Anne Baranger / Sui Huang
First evaluation 20 Aug 2008 | Latest evaluation 26 Aug 2008

Recommended
F1000 Factor 3.0

New Finding
Succinate receptor GPR91 provides a direct link between high glucose levels and renin release in murine and rabbit kidney.
Toma I, Kang JJ, …, Meer E, Peti-Peterdi J
J Clin Invest 2008 Jul 118(7):2526-34 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Matthew Breyer
Evaluated 20 Aug 2008


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