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Must Read
F1000 Factor 6.0

New Finding
 Mitochondrial cholesterol contributes to chemotherapy resistance in hepatocellular carcinoma.
Montero J, Morales A, …, Colell A, Fernández-Checa JC
Cancer Res 2008 Jul 1 68(13):5246-56 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Andrews
Evaluated 19 Nov 2008

Must Read
F1000 Factor 6.0

Hypothesis
New Finding
 Glucose induces an autocrine activation of the Wnt/beta-catenin pathway in macrophage cell lines.
Anagnostou SH, Shepherd PR
Biochem J 2008 Dec 1 416(2):211-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Alex Toker
Evaluated 18 Nov 2008

Recommended
F1000 Factor 3.0

Hypothesis
 Intestinal gluconeogenesis is a key factor for early metabolic changes after gastric bypass but not after gastric lap-band in mice.
Troy S, Soty M, …, Mithieux G, Andreelli F
Cell Metab 2008 Sep 8(3):201-11 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Joel Elmquist with Kevin W. Williams
Evaluated 18 Nov 2008

Must Read
F1000 Factor 6.0

Confirmation
Hypothesis
New Finding
Novel Drug Target
 Drug-dependent requirement of hippocampal neurogenesis in a model of depression and of antidepressant reversal.
Surget A, Saxe M, …, Hen R, Belzung C
Biol Psychiatry 2008 Aug 15 64(4):293-301 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Esther Sternberg with Marni Silverman
Evaluated 17 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
Novel Drug Target
 The succinate receptor GPR91 in neurons has a major role in retinal angiogenesis.
Sapieha P, Sirinyan M, …, Sennlaub F, Chemtob S
Nat Med 2008 Oct 14(10):1067-76 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Raymond Harris
Evaluated 17 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
 Testosterone for low libido in postmenopausal women not taking estrogen.
Davis SR, Moreau M, …, Studd J, APHRODITE Study Team
N Engl J Med 2008 Nov 6 359(19):2005-17 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | John Amory
Evaluated 17 Nov 2008

Must Read
F1000 Factor 6.0

Hypothesis
New Finding
 Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes.
Song B, Scheuner D, …, Pennathur S, Kaufman RJ
J Clin Invest 2008 Oct 118(10):3378-89 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Raghavendra Mirmira
Evaluated 11 Nov 2008

Must Read
F1000 Factor 6.0

Confirmation
Hypothesis
New Finding
 A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange.
Liu Y, Dentin R, …, Guarente L, Montminy M
Nature 2008 Oct 5 [abstract on PubMed] [related articles] [full text]
Selected by | Fredric Wondisford
Evaluated 6 Nov 2008

Must Read
F1000 Factor 6.0

New Finding
 Attenuation of amydgala and frontal cortical responses to low blood glucose concentration in asymptomatic hypoglycemia in type 1 diabetes: a new player in hypoglycemia unawareness?
Dunn JT, Cranston I, …, Amiel SA, Reed LJ
Diabetes 2007 Nov 56(11):2766-73 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Achim Peters
Evaluated 6 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
Novel Drug Target
 Curative and beta cell regenerative effects of alpha1-antitrypsin treatment in autoimmune diabetic NOD mice.
Koulmanda M, Bhasin M, …, Flier JS, Strom TB
Proc Natl Acad Sci U S A 2008 Oct 21 105(42):16242-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Mark Atkinson
Evaluated 4 Nov 2008


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