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Must Read
F1000 Factor 6.0

Hypothesis
New Finding
Aire controls the differentiation program of thymic epithelial cells in the medulla for the establishment of self-tolerance.
Yano M, Kuroda N, …, Mouri Y, Matsumoto M
J Exp Med 2008 Nov 17 [abstract on PubMed] [related articles] [full text]
Selected by | David Chaplin
Evaluated 19 Nov 2008

Recommended
F1000 Factor 3.0

Tech Advance
The transition from differential equations to Boolean networks: a case study in simplifying a regulatory network model.
Davidich M, Bornholdt S
J Theor Biol 2008 Dec 7 255(3):269-77 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Philip Maini
Evaluated 19 Nov 2008

Recommended
F1000 Factor 3.0

Hypothesis
Stimulation of Ebola virus production from persistent infection through activation of the Ras/MAPK pathway.
Strong JE, Wong G, …, Kobinger GP, Feldmann H
Proc Natl Acad Sci U S A 2008 Nov 3 105 [abstract on PubMed] [related articles] [full text]
Selected by | Kanta Subbarao with Catherine Luke
Evaluated 19 Nov 2008

Must Read
F1000 Factor 6.0

New Finding
Mitochondrial cholesterol contributes to chemotherapy resistance in hepatocellular carcinoma.
Montero J, Morales A, …, Colell A, Fernández-Checa JC
Cancer Res 2008 Jul 1 68(13):5246-56 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Andrews
Evaluated 19 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
Association between active genes occurs at nuclear speckles and is modulated by chromatin environment.
Brown JM, Green J, …, Iborra FJ, Buckle VJ
J Cell Biol 2008 Sep 22 182(6):1083-97 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Peter Shaw
Evaluated 18 Nov 2008

Must Read
F1000 Factor 6.0

Hypothesis
New Finding
Glucose induces an autocrine activation of the Wnt/beta-catenin pathway in macrophage cell lines.
Anagnostou SH, Shepherd PR
Biochem J 2008 Dec 1 416(2):211-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Alex Toker
Evaluated 18 Nov 2008

Must Read
F1000 Factor 6.0

Hypothesis
New Finding
Controversial
Hierarchical coding for sequential task events in the monkey prefrontal cortex.
Sigala N, Kusunoki M, …, Gaffan D, Duncan J
Proc Natl Acad Sci U S A 2008 Aug 19 105(33):11969-74 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Susan Courtney
Evaluated 18 Nov 2008

Recommended
F1000 Factor 3.0

Confirmation
New Finding
PPAR{gamma} and C/EBP factors orchestrate adipocyte biology via adjacent binding on a genome-wide scale.
Lefterova MI, Zhang Y, …, Liu XS, Lazar MA
Genes Dev 2008 Nov 1 22(21):2941-52 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Andrew D. Sharrocks
Evaluated 18 Nov 2008

Must Read
F1000 Factor 6.0

Confirmation
Hypothesis
Genome-wide linkage analysis of multiple measures of neuroticism of 2 large cohorts from Australia and the Netherlands.
Wray NR, Middeldorp CM, …, Martin NG, Boomsma DI
Arch Gen Psychiatry 2008 Jun 65(6):649-58 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Ian Deary with Lorna Houlihan
Evaluated 18 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
Persistent epigenetic differences associated with prenatal exposure to famine in humans.
Heijmans BT, Tobi EW, …, Slagboom PE, Lumey LH
Proc Natl Acad Sci U S A 2008 Nov 4 105(44):17046-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Wolf Reik
Evaluated 18 Nov 2008


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