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Must Read
F1000 Factor 6.0

Tech Advance
Dissecting T cell lineage relationships by cellular barcoding.
Schepers K, Swart E, …, Arens R, Schumacher TN
J Exp Med 2008 Sep 29 205(10):2309-18 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Thomas Hunig
Evaluated 6 Oct 2008

Exceptional
F1000 Factor 9.0

New Finding
Novel Drug Target
Selective nucleoside triphosphate diphosphohydrolase-2 (NTPDase2) inhibitors: nucleotide mimetics derived from uridine-5'-carboxamide.
Brunschweiger A, Iqbal J, …, Knowles AF, Müller CE
J Med Chem 2008 Aug 14 51(15):4518-28 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Geoffrey Burnstock
Evaluated 6 Oct 2008

Must Read
F1000 Factor 4.8

Hypothesis
New Finding
GILT is a critical host factor for Listeria monocytogenes infection.
Singh R, Jamieson A, Cresswell P
Nature 2008 Sep 24 [abstract on PubMed] [related articles] [full text]
Selected by | Peter Jensen / Clifford Harding
Evaluated 6 Oct 2008

Must Read
F1000 Factor 6.0

Confirmation
Tech Advance
Selecting aptamers for a glycoprotein through the incorporation of the boronic acid moiety.
Li M, Lin N, …, Fang H, Wang B
J Am Chem Soc 2008 Sep 24 130(38):12636-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Dennis Hall
Evaluated 6 Oct 2008

Recommended
F1000 Factor 3.0

New Finding
Spinocerebellar ataxia type 6 knockin mice develop a progressive neuronal dysfunction with age-dependent accumulation of mutant CaV2.1 channels.
Watase K, Barrett CF, …, Tsien RW, Zoghbi HY
Proc Natl Acad Sci U S A 2008 Aug 19 105(33):11987-92 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Annette Dolphin
Evaluated 6 Oct 2008

Recommended
F1000 Factor 3.0

Hypothesis
Controversial
Anti-amyloidogenic, anti-oxidant and anti-apoptotic role of gelsolin in Alzheimer's disease.
Chauhan V, Ji L, Chauhan A
Biogerontology 2008 Aug 15 [abstract on PubMed] [related articles] [full text]
Selected by | George Perry
Evaluated 3 Oct 2008

Recommended
F1000 Factor 3.0

New Finding
Inflammatory cytokines induce phosphorylation and ubiquitination of prostate suppressor protein NKX3.1.
Markowski MC, Bowen C, Gelmann EP
Cancer Res 2008 Sep 1 68(17):6896-901 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Simon Hayward
Evaluated 3 Oct 2008

Recommended
F1000 Factor 3.0

Hypothesis
Tech Advance
Rapid "open-source" engineering of customized zinc-finger nucleases for highly efficient gene modification.
Maeder ML, Thibodeau-Beganny S, …, Voytas DF, Joung JK
Mol Cell 2008 Jul 25 31(2):294-301 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Brian Kuhlman
Evaluated 3 Oct 2008

Recommended
F1000 Factor 3.0

New Finding
A domino effect in antifolate drug action in Escherichia coli.
Kwon YK, Lu W, …, Bognar A, Rabinowitz JD
Nat Chem Biol 2008 Oct 4(10):602-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Ruma Banerjee
Evaluated 3 Oct 2008

Recommended
F1000 Factor 3.0

Hypothesis
Architectures and functional coverage of protein-protein interfaces.
Tuncbag N, Gursoy A, …, Nussinov R, Keskin O
J Mol Biol 2008 Sep 5 381(3):785-802 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Narayanaswamy Srinivasan
Evaluated 3 Oct 2008


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