7-Oct-2008
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Must Read
F1000 Factor
6.0
Tech Advance
Dissecting T cell lineage relationships by cellular barcoding.
Schepers K, Swart E, …, Arens R, Schumacher TN
J Exp Med
2008 Sep 29
205
(10):2309-18 [
abstract on PubMed
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Selected by
| Thomas Hunig
Evaluated 6 Oct 2008
Exceptional
F1000 Factor
9.0
New Finding
Novel Drug Target
Selective nucleoside triphosphate diphosphohydrolase-2 (NTPDase2) inhibitors: nucleotide mimetics derived from uridine-5'-carboxamide.
Brunschweiger A, Iqbal J, …, Knowles AF, Müller CE
J Med Chem
2008 Aug 14
51
(15):4518-28 [
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Selected by
| Geoffrey Burnstock
Evaluated 6 Oct 2008
Must Read
F1000 Factor
4.8
Hypothesis
New Finding
GILT is a critical host factor for Listeria monocytogenes infection.
Singh R, Jamieson A, Cresswell P
Nature
2008 Sep 24 [
abstract on PubMed
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Selected by
| Peter Jensen
/ Clifford Harding
Evaluated 6 Oct 2008
Must Read
F1000 Factor
6.0
Confirmation
Tech Advance
Selecting aptamers for a glycoprotein through the incorporation of the boronic acid moiety.
Li M, Lin N, …, Fang H, Wang B
J Am Chem Soc
2008 Sep 24
130
(38):12636-8 [
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Selected by
| Dennis Hall
Evaluated 6 Oct 2008
Recommended
F1000 Factor
3.0
New Finding
Spinocerebellar ataxia type 6 knockin mice develop a progressive neuronal dysfunction with age-dependent accumulation of mutant CaV2.1 channels.
Watase K, Barrett CF, …, Tsien RW, Zoghbi HY
Proc Natl Acad Sci U S A
2008 Aug 19
105
(33):11987-92 [
abstract on PubMed
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Selected by
| Annette Dolphin
Evaluated 6 Oct 2008
Recommended
F1000 Factor
3.0
Hypothesis
Controversial
Anti-amyloidogenic, anti-oxidant and anti-apoptotic role of gelsolin in Alzheimer's disease.
Chauhan V, Ji L, Chauhan A
Biogerontology
2008 Aug 15 [
abstract on PubMed
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Selected by
| George Perry
Evaluated 3 Oct 2008
Recommended
F1000 Factor
3.0
New Finding
Inflammatory cytokines induce phosphorylation and ubiquitination of prostate suppressor protein NKX3.1.
Markowski MC, Bowen C, Gelmann EP
Cancer Res
2008 Sep 1
68
(17):6896-901 [
abstract on PubMed
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Selected by
| Simon Hayward
Evaluated 3 Oct 2008
Recommended
F1000 Factor
3.0
Hypothesis
Tech Advance
Rapid "open-source" engineering of customized zinc-finger nucleases for highly efficient gene modification.
Maeder ML, Thibodeau-Beganny S, …, Voytas DF, Joung JK
Mol Cell
2008 Jul 25
31
(2):294-301 [
abstract on PubMed
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Selected by
| Brian Kuhlman
Evaluated 3 Oct 2008
Recommended
F1000 Factor
3.0
New Finding
A domino effect in antifolate drug action in Escherichia coli.
Kwon YK, Lu W, …, Bognar A, Rabinowitz JD
Nat Chem Biol
2008 Oct
4
(10):602-8 [
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Selected by
| Ruma Banerjee
Evaluated 3 Oct 2008
Recommended
F1000 Factor
3.0
Hypothesis
Architectures and functional coverage of protein-protein interfaces.
Tuncbag N, Gursoy A, …, Nussinov R, Keskin O
J Mol Biol
2008 Sep 5
381
(3):785-802 [
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Selected by
| Narayanaswamy Srinivasan
Evaluated 3 Oct 2008
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