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Recommended
F1000 Factor 3.0

Hypothesis
New Finding
Controversial
 Structural and functional evidence that Nck interaction with CD3epsilon regulates T-cell receptor activity.
Takeuchi K, Yang H, …, Reinherz EL, Wagner G
J Mol Biol 2008 Jul 18 380(4):704-16 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Michael Dustin with Kaushik Choudhuri
Evaluated 4 Sep 2008

Recommended
F1000 Factor 3.0

Hypothesis
Controversial
Novel Drug Target
 Specificity in cancer immunotherapy.
Schietinger A, Philip M, Schreiber H
Semin Immunol 2008 Aug 4 [abstract on PubMed] [related articles] [full text]
Selected by | David Kranz
Evaluated 4 Sep 2008

Recommended
F1000 Factor 3.0

New Finding
 Th1, Th2, and Th17 effector T cell-induced autoimmune gastritis differs in pathological pattern and in susceptibility to suppression by regulatory T cells.
Stummvoll GH, DiPaolo RJ, …, Ward JM, Shevach EM
J Immunol 2008 Aug 1 181(3):1908-16 [abstract on PubMed] [related articles] [order article]
Selected by | Paul Gleeson
Evaluated 4 Sep 2008

Recommended
F1000 Factor 3.0

Hypothesis
New Finding
 Role of the histone H3 lysine 4 methyltransferase, SET7/9, in the regulation of NF-kappa B dependent inflammatory genes: Relevance to diabetes and inflammation.
Li Y, Reddy MA, …, Ren B, Natarajan R
J Biol Chem 2008 Jul 23 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Raghavendra Mirmira
Evaluated 4 Sep 2008

Recommended
F1000 Factor 3.0

New Finding
 CD4+FoxP3+ regulatory T cells confer infectious tolerance in a TGF-{beta}-dependent manner.
Andersson J, Tran DQ, …, O'Shea JJ, Shevach EM
J Exp Med 2008 Aug 18 205 [abstract on PubMed] [related articles] [full text]
Selected by | Ed Palmer with Carolyn King
Evaluated 4 Sep 2008

Recommended
F1000 Factor 3.0

Hypothesis
New Finding
 Expression of Wiskott-Aldrich syndrome protein in dendritic cells regulates synapse formation and activation of naive CD8+ T cells.
Pulecio J, Tagliani E, …, Burrone OR, Benvenuti F
J Immunol 2008 Jul 15 181(2):1135-42 [abstract on PubMed] [related articles] [order article]
Selected by | Michael Dustin with Kaushik Choudhuri
Evaluated 4 Sep 2008

Exceptional
F1000 Factor 9.0

Hypothesis
New Finding
Tech Advance
Novel Drug Target
 Bacterial peptidoglycan triggers Candida albicans hyphal growth by directly activating the adenylyl cyclase Cyr1p.
Xu XL, Lee RT, …, Zhu Y, Wang Y
Cell Host Microbe 2008 Jul 17 4(1):28-39 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Joe Heitman
Evaluated 4 Sep 2008

Must Read
F1000 Factor 6.0

Hypothesis
New Finding
 Gliadin induces an increase in intestinal permeability and zonulin release by binding to the chemokine receptor CXCR3.
Lammers KM, Lu R, …, Vogel SN, Fasano A
Gastroenterology 2008 Jul 135(1):194-204.e3 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Marc Rothenberg
Evaluated 4 Sep 2008

Recommended
F1000 Factor 3.0

New Finding
 Allelic variants of streptokinase from Streptococcus pyogenes display functional differences in plasminogen activation.
McArthur JD, McKay FC, …, Ranson M, Walker MJ
FASEB J 2008 Sep 22(9):3146-53 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Victor Nizet
Evaluated 4 Sep 2008

Recommended
F1000 Factor 3.0

Confirmation
New Finding
 Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease.
McCarroll SA, Huett A, …, Daly MJ, Xavier RJ
Nat Genet 2008 Aug 24 40 [abstract on PubMed] [related articles] [full text]
Selected by | Vojo Deretic with Isabelle Vergne
Evaluated 4 Sep 2008


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