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Exceptional
F1000 Factor 9.0

Confirmation
Caspase-3 Is Enriched in Postsynaptic Densities and Increased in Alzheimer's Disease.
Louneva N, Cohen JW, …, Trojanowski JQ, Arnold SE
Am J Pathol 2008 Sep 25 [abstract on PubMed] [related articles] [full text]
Selected by | Rudolph Tanzi
Evaluated 10 Oct 2008

Must Read
F1000 Factor 6.0

New Finding
Tech Advance
The type IV mucolipidosis-associated protein TRPML1 is an endolysosomal iron release channel.
Dong XP, Cheng X, …, Kurz T, Xu H
Nature 2008 Sep 14 [abstract on PubMed] [related articles] [full text]
Selected by | Sharona Gordon
Evaluated 9 Oct 2008

Must Read
F1000 Factor 6.0

New Finding
Refutation
Cutting Edge: Th1 cells facilitate the entry of Th17 cells to the central nervous system during experimental autoimmune encephalomyelitis.
O'Connor RA, Prendergast CT, …, Wraith DC, Anderton SM
J Immunol 2008 Sep 15 181(6):3750-4 [abstract on PubMed] [related articles] [order article]
Selected by | Thomas Hunig
Evaluated 9 Oct 2008

Must Read
F1000 Factor 6.0

Hypothesis
Beyond transcription factors: the role of chromatin modifying enzymes in regulating transcription required for memory.
Barrett RM, Wood MA
Learn Mem 2008 15(7):460-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Peter Rapp
Evaluated 9 Oct 2008

Recommended
F1000 Factor 3.0

New Finding
Tech Advance
How changes in the sequence of the peptide CLPFFD-NH2 can modify the conjugation and stability of gold nanoparticles and their affinity for beta-amyloid fibrils.
Olmedo I, Araya E, …, Giralt E, Kogan MJ
Bioconjug Chem 2008 Jun 19(6):1154-63 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | George Perry
Evaluated 9 Oct 2008

Recommended
F1000 Factor 3.0

New Finding
Novel Drug Target
Age-dependent epigenetic control of differentiation inhibitors is critical for remyelination efficiency.
Shen S, Sandoval J, …, Franklin RJ, Casaccia-Bonnefil P
Nat Neurosci 2008 Aug 24 [abstract on PubMed] [related articles] [full text]
Selected by | Peter Rapp
Evaluated 9 Oct 2008

Must Read
F1000 Factor 6.0

New Finding
Membrane potential shifts caused by diffusible guidance signals direct growth-cone turning.
Nishiyama M, von Schimmelmann MJ, …, Findley WM, Hong K
Nat Neurosci 2008 Jul 11(7):762-71 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Frank Walsh
Evaluated 9 Oct 2008

Recommended
F1000 Factor 3.0

New Finding
Increased oxidation, glycoxidation, and lipoxidation of brain proteins in prion disease.
Pamplona R, Naudí A, …, Ferrer I, Requena JR
Free Radic Biol Med 2008 Jul 23 [abstract on PubMed] [related articles] [full text]
Selected by | George Perry
Evaluated 9 Oct 2008

Recommended
F1000 Factor 3.0

New Finding
Truncated tau expression levels determine life span of a rat model of tauopathy without causing neuronal loss or correlating with terminal neurofibrillary tangle load.
Koson P, Zilka N, …, Filipcik P, Novak M
Eur J Neurosci 2008 Jul 28(2):239-46 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | George Perry
Evaluated 9 Oct 2008

Must Read
F1000 Factor 6.0

New Finding
The critical importance of retrieval for learning.
Karpicke JD, Roediger HL
Science 2008 Feb 15 319(5865):966-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Ken Norman
Evaluated 8 Oct 2008



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