7-Oct-2008
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Recommended
F1000 Factor
3.0
New Finding
Transforming growth factor-beta suppresses the activation of CD8+ T-cells when naive but promotes their survival and function once antigen experienced: a two-faced impact on autoimmunity.
Filippi CM, Juedes AE, …, Flavell RA, von Herrath MG
Diabetes
2008 Oct
57
(10):2684-92 [
abstract on PubMed
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full text
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Selected by
| Bart Roep
Evaluated 6 Oct 2008
Exceptional
F1000 Factor
9.0
New Finding
Novel Drug Target
Selective nucleoside triphosphate diphosphohydrolase-2 (NTPDase2) inhibitors: nucleotide mimetics derived from uridine-5'-carboxamide.
Brunschweiger A, Iqbal J, …, Knowles AF, Müller CE
J Med Chem
2008 Aug 14
51
(15):4518-28 [
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Selected by
| Geoffrey Burnstock
Evaluated 6 Oct 2008
Must Read
F1000 Factor
4.8
Hypothesis
New Finding
GILT is a critical host factor for Listeria monocytogenes infection.
Singh R, Jamieson A, Cresswell P
Nature
2008 Sep 24 [
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Selected by
| Peter Jensen
/ Clifford Harding
Evaluated 6 Oct 2008
Recommended
F1000 Factor
3.0
New Finding
Spinocerebellar ataxia type 6 knockin mice develop a progressive neuronal dysfunction with age-dependent accumulation of mutant CaV2.1 channels.
Watase K, Barrett CF, …, Tsien RW, Zoghbi HY
Proc Natl Acad Sci U S A
2008 Aug 19
105
(33):11987-92 [
abstract on PubMed
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FREE full text
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Selected by
| Annette Dolphin
Evaluated 6 Oct 2008
Recommended
F1000 Factor
3.0
New Finding
T-bet expression by dendritic cells is required for the repolarization of allergic airway inflammation.
Heckman KL, Radhakrishnan S, …, Kita H, Pease LR
Eur J Immunol
2008 Sep
38
(9):2464-74 [
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| Santa Jeremy Ono
Evaluated 6 Oct 2008
Must Read
F1000 Factor
6.0
New Finding
Novel Drug Target
Reduced atherosclerotic lesions in P2Y1/apolipoprotein E double-knockout mice: the contribution of non-hematopoietic-derived P2Y1 receptors.
Hechler B, Freund M, …, Cazenave JP, Gachet C
Circulation
2008 Aug 12
118
(7):754-63 [
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Selected by
| Geoffrey Burnstock
Evaluated 6 Oct 2008
Must Read
F1000 Factor
6.0
New Finding
Reproducibility of QuantiFERON-TB gold in-tube assay.
Perry S, Sanchez L, …, Hurst P, Parsonnet J
Clin Vaccine Immunol
2008 Mar
15
(3):425-32 [
abstract on PubMed
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FREE full text
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Selected by
| Gaby Pfyffer
Evaluated 6 Oct 2008
Recommended
F1000 Factor
3.0
New Finding
The immunity-related GTPase Irgm1 promotes the expansion of activated CD4(+) T cell populations by preventing interferon-gamma-induced cell death.
Feng CG, Zheng L, …, Lenardo MJ, Sher A
Nat Immunol
2008 Sep 21 [
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Selected by
| George Yap
Evaluated 3 Oct 2008
Must Read
F1000 Factor
6.0
New Finding
Novel Drug Target
Selective loss of P2Y2 nucleotide receptor immunoreactivity is associated with Alzheimer's disease neuropathology.
Lai MK, Tan MG, …, Chen CP, Francis PT
J Neural Transm
2008 Aug
115
(8):1165-72 [
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Selected by
| Geoffrey Burnstock
Evaluated 3 Oct 2008
Recommended
F1000 Factor
3.0
Hypothesis
Association between paracetamol use in infancy and childhood, and risk of asthma, rhinoconjunctivitis, and eczema in children aged 6-7 years: analysis from Phase Three of the ISAAC programme.
Beasley R, Clayton T, …, Stewart A, ISAAC Phase Three Study Group
Lancet
2008 Sep 20
372
(9643):1039-48 [
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Selected by
| Dale Umetsu
Evaluated 3 Oct 2008
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