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Must Read
F1000 Factor 6.0

Hypothesis
New Finding
Tech Advance
 Specific DNA-binding by apicomplexan AP2 transcription factors.
De Silva EK, Gehrke AR, …, Bulyk ML, Llinás M
Proc Natl Acad Sci U S A 2008 Jun 17 105(24):8393-8 [abstract on PubMed] [related articles] [FREE full text]
Selected by | L. David Sibley
Evaluated 4 Jul 2008

Exceptional
F1000 Factor 9.0

Hypothesis
New Finding
Tech Advance
 Proliferating cells express mRNAs with shortened 3' untranslated regions and fewer microRNA target sites.
Sandberg R, Neilson JR, …, Sharp PA, Burge CB
Science 2008 Jun 20 320(5883):1643-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | E. Charles Snow
Evaluated 4 Jul 2008

Recommended
F1000 Factor 3.0

New Finding
 Both daughter cells traffic and exocytose membrane at the cleavage furrow during mammalian cytokinesis.
Goss JW, Toomre DK
J Cell Biol 2008 Jun 30 181(7):1047-1054 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Peter Mayinger
Evaluated 4 Jul 2008

Recommended
F1000 Factor 3.0

New Finding
 Caenorhabditis elegans genes required for the engulfment of apoptotic corpses function in the cytotoxic cell deaths induced by mutations in lin-24 and lin-33.
Galvin BD, Kim S, Horvitz HR
Genetics 2008 May 179(1):403-17 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Shai Shaham
Evaluated 4 Jul 2008

Recommended
F1000 Factor 3.0

New Finding
Tech Advance
 Direct inhibition of the DNA-binding activity of POU transcription factors Pit-1 and Brn-3 by selective binding of a phenyl-furan-benzimidazole dication.
Peixoto P, Liu Y, …, Wilson WD, David-Cordonnier MH
Nucleic Acids Res 2008 Jun 36(10):3341-53 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Jim Maher
Evaluated 4 Jul 2008

Recommended
F1000 Factor 3.0

New Finding
 Recruitment of Stat1 to chromatin is required for interferon-induced serine phosphorylation of Stat1 transactivation domain.
Sadzak I, Schiff M, …, Schaljo B, Kovarik P
Proc Natl Acad Sci U S A 2008 Jun 23 105 [abstract on PubMed] [related articles] [full text]
Selected by | David Levy
Evaluated 4 Jul 2008

Recommended
F1000 Factor 3.0

New Finding
 The coactivators CBP/p300 and the histone chaperone NAP1 promote transcription-independent nucleosome eviction at the HTLV-1 promoter.
Sharma N, Nyborg JK
Proc Natl Acad Sci U S A 2008 Jun 10 105(23):7959-63 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Paul Kaufman
Evaluated 4 Jul 2008

Must Read
F1000 Factor 6.0

New Finding
 Bicaudal-C recruits CCR4-NOT deadenylase to target mRNAs and regulates oogenesis, cytoskeletal organization, and its own expression.
Chicoine J, Benoit P, …, Simonelig M, Lasko P
Dev Cell 2007 Nov 13(5):691-704 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Samuel Gunderson
Evaluated 4 Jul 2008

Must Read
F1000 Factor 6.0

Confirmation
 Selective loss of leptin receptors in the ventromedial hypothalamic nucleus results in increased adiposity and a metabolic syndrome.
Bingham NC, Anderson KK, …, Stallings NR, Parker KL
Endocrinology 2008 May 149(5):2138-48 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Achim Peters
Evaluated 4 Jul 2008

Must Read
F1000 Factor 6.0

Hypothesis
New Finding
 Termination factor Rho and its cofactors NusA and NusG silence foreign DNA in E. coli.
Cardinale CJ, Washburn RS, …, Gottesman ME, Nudler E
Science 2008 May 16 320(5878):935-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Judy Wall
Evaluated 4 Jul 2008


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