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Must Read
F1000 Factor 6.0

Hypothesis
New Finding
 Origins and evolution of eukaryotic RNA interference.
Shabalina SA, Koonin EV
Trends Ecol Evol 2008 Aug 18 [abstract on PubMed] [related articles] [full text]
Selected by | Marjori Matzke
Evaluated 5 Sep 2008


Recommended
F1000 Factor 3.0

Tech Advance
 mirWIP: microRNA target prediction based on microRNA-containing ribonucleoprotein-enriched transcripts.
Hammell M, Long D, …, Ding Y, Ambros V
Nat Methods 2008 Aug 17 5 [abstract on PubMed] [related articles] [full text]
Selected by | Robert K Herman
Evaluated 5 Sep 2008

Must Read
F1000 Factor 6.0

Hypothesis
Controversial
 Nanoscale organization of hedgehog is essential for long-range signaling.
Vyas N, Goswami D, …, Sowdhamini R, Mayor S
Cell 2008 Jun 27 133(7):1214-27 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | John Couchman
Evaluated 4 Sep 2008

Recommended
F1000 Factor 3.0

New Finding
 The structure of CCT-Hsc70 NBD suggests a mechanism for Hsp70 delivery of substrates to the chaperonin.
Cuéllar J, Martín-Benito J, …, Carrascosa JL, Valpuesta JM
Nat Struct Mol Biol 2008 Aug 15(8):858-64 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Sophie Jackson
Evaluated 4 Sep 2008

Exceptional
F1000 Factor 9.0

Hypothesis
New Finding
Tech Advance
Novel Drug Target
 Bacterial peptidoglycan triggers Candida albicans hyphal growth by directly activating the adenylyl cyclase Cyr1p.
Xu XL, Lee RT, …, Zhu Y, Wang Y
Cell Host Microbe 2008 Jul 17 4(1):28-39 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Joe Heitman
Evaluated 4 Sep 2008

Recommended
F1000 Factor 3.0

Confirmation
New Finding
Tech Advance
 In vivo reconstitution of autophagy in Saccharomyces cerevisiae.
Cao Y, Cheong H, Song H, Klionsky DJ
J Cell Biol 2008 Aug 25 182(4):703-13 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Vojo Deretic
Evaluated 4 Sep 2008

Must Read
F1000 Factor 6.4

Confirmation
New Finding
Tech Advance
 Functional auditory hair cells produced in the mammalian cochlea by in utero gene transfer.
Gubbels SP, Woessner DW, …, Ricci AJ, Brigande JV
Nature 2008 Aug 27 [abstract on PubMed] [related articles] [full text]
Selected by | Harukazu Nakamura / Andy Groves
Evaluated 4 Sep 2008

Exceptional
F1000 Factor 8.0

Hypothesis
New Finding
 In vivo reprogramming of adult pancreatic exocrine cells to beta-cells.
Zhou Q, Brown J, …, Rajagopal J, Melton DA
Nature 2008 Aug 27 [abstract on PubMed] [related articles] [full text]
Selected by | Anthony Means / Phillip Newmark
First evaluation 4 Sep 2008 | Latest evaluation 5 Sep 2008

Recommended
F1000 Factor 3.0

New Finding
 Structural analysis of the recognition of the negative regulator NmrA and DNA by the zinc finger from the GATA-type transcription factor AreA.
Kotaka M, Johnson C, …, Ren J, Stammers DK
J Mol Biol 2008 Aug 29 381(2):373-82 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Lin Chen
Evaluated 4 Sep 2008

Must Read
F1000 Factor 6.0

Hypothesis
New Finding
Tech Advance
 Imaging of the yellow cameleon 3.6 indicator reveals that elevations in cytosolic Ca2+ follow oscillating increases in growth in root hairs of Arabidopsis.
Monshausen GB, Messerli MA, Gilroy S
Plant Physiol 2008 Aug 147(4):1690-8 [abstract on PubMed] [related articles] [FREE full text]
Selected by | John Ward
Evaluated 3 Sep 2008


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