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Must Read
F1000 Factor 6.0

New Finding
 CTLA-4 blockade increases IFNgamma-producing CD4+ICOShi cells to shift the ratio of effector to regulatory T cells in cancer patients.
Liakou CI, Kamat A, …, Logothetis C, Sharma P
Proc Natl Acad Sci U S A 2008 Sep 30 105(39):14987-92 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Glenn Dranoff
Evaluated 10 Oct 2008

Recommended
F1000 Factor 3.0

Hypothesis
New Finding
Tech Advance
 Spatial organization of a replicating bacterial chromosome.
Berlatzky IA, Rouvinski A, Ben-Yehuda S
Proc Natl Acad Sci U S A 2008 Sep 16 105(37):14136-40 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Linda Amos
Evaluated 10 Oct 2008

Recommended
F1000 Factor 3.0

New Finding
Tech Advance
 Bioencapsulation of living bacteria (Escherichia coli) with poly(silicate) after transformation with silicatein-alpha gene.
Müller WE, Engel S, …, Divekar M, Schröder HC
Biomaterials 2008 Mar 29(7):771-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Russell Hill
Evaluated 9 Oct 2008

Recommended
F1000 Factor 3.0

New Finding
 Molecular analysis of a novel gene cluster encoding an insect toxin in plant-associated strains of Pseudomonas fluorescens.
Péchy-Tarr M, Bruck DJ, …, Loper JE, Keel C
Environ Microbiol 2008 Sep 10(9):2368-86 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Ben Lugtenberg
Evaluated 9 Oct 2008

Must Read
F1000 Factor 6.0

Hypothesis
New Finding
 Recognition of misfolded proteins by Lon, a AAA(+) protease.
Gur E, Sauer RT
Genes Dev 2008 Aug 15 22(16):2267-77 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Tracy Raivio
Evaluated 9 Oct 2008

Recommended
F1000 Factor 3.0

New Finding
 Conserved factors Ryp2 and Ryp3 control cell morphology and infectious spore formation in the fungal pathogen Histoplasma capsulatum.
Webster RH, Sil A
Proc Natl Acad Sci U S A 2008 Sep 23 105(38):14573-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Gerhard Braus
Evaluated 9 Oct 2008

Recommended
F1000 Factor 3.0

Confirmation
Tech Advance
 Quantification of ligand-regulated nuclear receptor corepressor and coactivator binding, key interactions determining ligand potency and efficacy for the thyroid hormone receptor.
Jeyakumar M, Webb P, …, Scanlan TS, Katzenellenbogen JA
Biochemistry 2008 Jul 15 47(28):7465-76 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Donald Doyle
Evaluated 9 Oct 2008

Recommended
F1000 Factor 3.0

New Finding
 Increased oxidation, glycoxidation, and lipoxidation of brain proteins in prion disease.
Pamplona R, Naudí A, …, Ferrer I, Requena JR
Free Radic Biol Med 2008 Jul 23 [abstract on PubMed] [related articles] [full text]
Selected by | George Perry
Evaluated 9 Oct 2008

Recommended
F1000 Factor 3.0

New Finding
Tech Advance
 A novel biochemical method to identify target genes of individual microRNAs: Identification of a new Caenorhabditis elegans let-7 target.
Andachi Y
RNA 2008 Sep 29 [abstract on PubMed] [related articles] [full text]
Selected by | Morris Maduro
Evaluated 9 Oct 2008

Recommended
F1000 Factor 3.0

New Finding
 The anti-herpetic drug acyclovir inhibits HIV replication and selects the V75i reverse transcriptase multi-drug resistance mutation.
McMahon MA, Siliciano JD, …, Siliciano RF, Kohli RM
J Biol Chem 2008 Sep 26 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Jonathan Schapiro
Evaluated 9 Oct 2008


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