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Recommended
F1000 Factor 3.0

Refutation
 The chemokine receptor Cxcr3 is not essential for acute cardiac allograft rejection in mice and rats.
Zerwes HG, Li J, …, Thoma G, Luckow B
Am J Transplant 2008 Aug 8(8):1604-13 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Mohamed Sayegh with Jessamyn Bagley
Evaluated 29 Aug 2008

Must Read
F1000 Factor 6.0

New Finding
Controversial
 TSCOT+ thymic epithelial cell-mediated sensitive CD4 tolerance by direct presentation.
Ahn S, Lee G, …, Restifo NP, Kim MG
PLoS Biol 2008 Aug 5 6(8):e191 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Gerald Spangrude
Evaluated 29 Aug 2008

Recommended
F1000 Factor 3.0

Tech Advance
 Site-specific crosslinking of human microRNPs to RNA targets.
Kirino Y, Mourelatos Z
RNA 2008 Aug 21 [abstract on PubMed] [related articles] [full text]
Selected by | Kevin J. Luebke
Evaluated 29 Aug 2008

Must Read
F1000 Factor 6.0

Tech Advance
 The associative nature of adenylyl transfer catalyzed by T4 DNA ligase.
Cherepanov AV, Doroshenko EV, …, de Vries S, de Groot HJ
Proc Natl Acad Sci U S A 2008 Jun 24 105(25):8563-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Arieh Warshel with Shina Caroline Lynn Kamerlin
Evaluated 29 Aug 2008

Recommended
F1000 Factor 3.0

Hypothesis
New Finding
 Human Metastasis Regulator Protein H-Prune is a Short-Chain Exopolyphosphatase.
Tammenkoski M, Koivula K, …, Baykov AA, Lahti R
Biochemistry 2008 Aug 14 0 [abstract on PubMed] [related articles] [full text]
Selected by | Roberto Docampo
Evaluated 29 Aug 2008

Recommended
F1000 Factor 3.0

Hypothesis
New Finding
Controversial
 A Role for Confined Water in Chaperonin Function.
England JL, Lucent D, Pande VS
J Am Chem Soc 2008 Aug 19 0 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Joan Shea
Evaluated 29 Aug 2008

Recommended
F1000 Factor 3.0

Confirmation
New Finding
 Smoothelin-B deficiency results in reduced arterial contractility, hypertension, and cardiac hypertrophy in mice.
Rensen SS, Niessen PM, …, De Mey JG, van Eys GJ
Circulation 2008 Aug 19 118(8):828-36 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Giulio Gabbiani
Evaluated 29 Aug 2008

Recommended
F1000 Factor 3.0

Hypothesis
New Finding
 OSM-11 Facilitates LIN-12 Notch Signaling during Caenorhabditis elegans Vulval Development.
Komatsu H, Chao MY, …, Boxem M, Hart AC
PLoS Biol 2008 Aug 12 6(8):e196 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Helen Chamberlin
Evaluated 29 Aug 2008

Recommended
F1000 Factor 3.0

New Finding
 Adaptive evolution and functional redesign of core metabolic proteins in snakes.
Castoe TA, Jiang ZJ, …, Wang ZO, Pollock DD
PLoS ONE 2008 3(5):e2201 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Nicolas Galtier
Evaluated 29 Aug 2008

Recommended
F1000 Factor 3.0

New Finding
 Hypomethylation of multiple imprinted loci in individuals with transient neonatal diabetes is associated with mutations in ZFP57.
Mackay DJ, Callaway JL, …, Robinson DO, Temple IK
Nat Genet 2008 Aug 40(8):949-51 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Wolf Reik
Evaluated 29 Aug 2008


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