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F1000 Factor 3.0

New Finding
Tech Advance
 Alternative isoform regulation in human tissue transcriptomes.
Wang ET, Sandberg R, …, Schroth GP, Burge CB
Nature 2008 Nov 2 [abstract on PubMed] [related articles] [full text]
Selected by | Ken Irvine with Yongqiang Feng
Evaluated 20 Nov 2008

Must Read
F1000 Factor 6.0

Tech Advance
Novel Drug Target
 Chemical control of protein stability and function in living mice.
Banaszynski LA, Sellmyer MA, …, Wandless TJ, Thorne SH
Nat Med 2008 Oct 14(10):1123-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Ken Irvine with Yongqiang Feng
Evaluated 20 Nov 2008

Recommended
F1000 Factor 3.0

Hypothesis
New Finding
 Platelet glycoprotein Ibalpha forms catch bonds with human WT vWF but not with type 2B von Willebrand disease vWF.
Yago T, Lou J, …, McEver RP, Zhu C
J Clin Invest 2008 Sep 118(9):3195-207 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Xiaoping Du
Evaluated 20 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
 Temporal requirement of the alternative-splicing factor Sfrs1 for the survival of retinal neurons.
Kanadia RN, Clark VE, …, Trimarchi JM, Cepko CL
Development 2008 Dec 135(23):3923-33 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Reinhard Luehrmann
Evaluated 20 Nov 2008

Recommended
F1000 Factor 3.0

Confirmation
New Finding
 KANADI1 regulates adaxial-abaxial polarity in Arabidopsis by directly repressing the transcription of ASYMMETRIC LEAVES2.
Wu G, Lin WC, …, Springer PS, Kerstetter RA
Proc Natl Acad Sci U S A 2008 Oct 21 105(42):16392-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jennifer Fletcher with Chan Man Ha
Evaluated 19 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
 The LPS-induced transcriptional upregulation of the chicken lysozyme locus involves CTCF eviction and noncoding RNA transcription.
Lefevre P, Witham J, …, Cockerill PN, Bonifer C
Mol Cell 2008 Oct 10 32(1):129-39 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Rob White
Evaluated 19 Nov 2008

Must Read
F1000 Factor 6.0

Hypothesis
New Finding
 Aire controls the differentiation program of thymic epithelial cells in the medulla for the establishment of self-tolerance.
Yano M, Kuroda N, …, Mouri Y, Matsumoto M
J Exp Med 2008 Nov 17 [abstract on PubMed] [related articles] [full text]
Selected by | David Chaplin
Evaluated 19 Nov 2008

Recommended
F1000 Factor 3.0

Confirmation
New Finding
 Increased avian diversity is associated with lower incidence of human West Nile infection: observation of the dilution effect.
Swaddle JP, Calos SE
PLoS ONE 2008 3(6):e2488 [abstract on PubMed] [related articles] [FREE full text]
Selected by | J. Emmett Duffy
Evaluated 19 Nov 2008

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F1000 Factor 3.0

New Finding
Tech Advance
 Light enhanced amino acid uptake by dominant bacterioplankton groups in surface waters of the Atlantic Ocean.
Mary I, Tarran GA, …, Burkill PH, Zubkov MV
FEMS Microbiol Ecol 2008 Jan 63(1):36-45 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | John Hobbie with Hugh Ducklow
Evaluated 19 Nov 2008

Must Read
F1000 Factor 6.0

New Finding
Tech Advance
 Reduced carbon sequestration in terrestrial ecosystems under overcast skies compared to clear skies.
Alton PB
Agric For Meteorol 2008 148:1641-53 [full text]
Selected by | Dennis Baldocchi
Evaluated 19 Nov 2008


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