SECTION	SCOPE
Antimicrobial Agents	Adjuncts for anti-microbial therapy (e.g. anti-penicillinase, renal excretion modifiers etc) Anti-bacterial agents Anti-parasite/anti-malarials Anti-viral agents Clinical properties of anti-microbial agents Resistance to anti-microbial agents
Bioinformatics	Algorithms Comparative genomics Computational genomics Databases Linkage analysis Statistics of sequence comparison Structural biology
Biomacromolecule-Ligand Interactions	Inhibitors Protein binding studies Structural basis of binding Theoretical aspects of binding
Cancer Therapeutics	Cancer immunology & interaction with anticancer agents Identification of molecular targets for therapy (e.g. malignant cells & blood vessels) Mechanisms of drug action Targets for chemoprevention
Cardiovascular Pharmacology	Arrhythmias Atherosclerosis Cardiovascular risk factors Congestive heart failure Dyslipidemia Hypertension Hypotension Inflammation
Cell Signalling	Calcium Cell signalling in apoptosis, damage & senescence Cell signalling in cell cycle control Cytoplasmic/nuclear receptors G proteins Kinases & phosphatases: serine/threonine kinases, tyrosine kinases, phosphatases & smGTPases Lipids, inositol lipids & phosphates Modelling Nucleotides, nucleosides, amino acids & their receptors Peptide hormones, growth factors & their receptors Redox signalling Scaffolds/protein interactions Signalling & adhesion Signalling & regulation of gene expression Signalling & the cytoskeleton Small molecule targeting Technology: imaging/signalling Technology: proteomics Two-component signalling
Cell Signalling & Trafficking Structures	Apoptotic pathways Developmental pathways Extracellular receptor ligand interactions G-protein coupled receptor signalling Intracellular receptor domain interactions Kinases & phosphatases Nuclear import/export Second messenger generation & responses Signalling in the immune system Small GTPases & their regulation Vesicle targeting & fusion
Chemical Biology of the Cell	Cell surface engineering Chemical genetics Intracellular monitoring Metabolic pathway engineering Modulation of signal transduction Protein-protein interactions Receptor-ligand interactions Sensors & imaging Single cell metabolite assays Transcriptional regulation & control
Directed Molecular Evolution	Aptamers Bioprospecting & enzyme discovery Catalytic antibodies Combinatorial biosynthesis Directed evolution Generation of diversity In vitro selection Molecular ecology Phage/ribosome display Theoretical foundations of molecular evolution
Drug Discovery & Design	Combinatorial chemistry Drug approval & regulatory aspects High-throughput screening In-silico drug design Medicinal chemistry Pharmacoeconomics Structure-activity relationships Target discovery & validation
Endocrine & Metabolic Pharmacology	Anti-diabetes therapy Cholesterol lowering drugs Hormonal agonists & antagonists Steroids/body building Therapy for calcium disorders Therapy for other endocine/metabolic disorders Therapy for thyroid disorders Treatment of eating disorders (including obesity) Vitamin therapy & dietry supplements
Gastrointestinal Pharmacology	Anti-inflammatories Constipation Diarrhoea Drugs for hepatic disorders Functional bowel disease: diarrhoea, constipation Functional bowel disease: nausea and abdominal pain Gastroparesis Gut wall absorption of drugs Incontinence Infections of GI tract Therapy of gastric acidity disorders Therapy of inflammatory bowel disease
Genito-Urinary & Reproductive Pharmacology	Contraception Drugs used during pregnancy Infertility & fertility drugs Menstruation/menopause Sexual dysfunction Testosterone replacement & therapy Therapy for lower urinary tract disorders Therapy for prostate & penile disorders Therapy for uterine disorders
Genomics	Computational analysis Expression analysis General genomics expertise High-throughput genome technology Mapping and sequencing Proteomics
Immunopharmacology & Hematologic Pharmacology	Anemias Anti-allergy drugs Anti-inflammatory drugs Cytokines as drug targets Disorders of leukocytes (other than cancer) Immunomodulating agents Immunotherapy & vaccines Immunotoxicology Platelet disorders
Macromolecular Chemistry	Carbohydrates (including glycosaminoglycans & polysaccharides) Chemical synthesis of natural & non-natural proteins Glycoproteins & glycolipids Lipids, liposomes, membranes Macromolecular arrays, synthesis & analysis of macromolecular arrays (AFM, SPR, etc., new patterning methods, etc.) Macromolecular conjugates Microarrays Non-natural biologically active polymers Non-natural glycoconjugates & glycoprotein analogs Nucleic acid analogs Nucleic acid catalysis Protein modification RNA/DNA folding
Medical Genetics	Complex & simple gene mapping Gene therapy Genetic basis of diseases Pre-/post-natal diagnosis
Molecular Pharmacology	Ligands (agonists/antagonists) Signal transduction mechanisms (g proteins, kinases/phosphatases, calcium) Molecular modeling & databases Receptors (gpcrs, tyrosine kinases, ion channels nuclear vs cytoplasmic etc) Structure-function of important drug classes
Musculoskeletal & Dermatologic Pharmacology	Drugs for muscle/connective tissue Drugs for bone disorders (eg osteoporosis) Drugs for skin conditions (eg acne, anti-wrinkle creams, botox etc)
Neuropharmacology & Psychopharmacology	Analgesics Anti-epileptic drugs Blockers of transmitter synthesis, storage, uptake Bockers of neuroexcitation Chronopharmacology Drugs for cerebrovascular disease Drugs for eye disorders Drugs for learning & attention disorders Drugs for motor disorders Drugs for psychiatric disorders Drugs of abuse Sensory pharmacology (other than eye)
Pharmacogenomics	Comparative (evolutionary) pharmacology Genetic factors influencing pharmacodynamics Genetic factors influencing pharmacokinetics Genetically identified drug targets (e.g. orphan receptors) Genetic screening Tailoring drugs to individuals/populations
Pharmacokinetics & Drug Delivery	Bioavailability, drug distribution, metabolism (phase I and phase II enzymes) & excretion Drug delivery (including gene therapy & stem cells as delivery systems; blood-brain barrier) Drug interactions Pharmacokinetics Therapeutic drug monitoring
Physiogenomics	Scope: Approaches, results & interpretation that integrate molecular information for whole organisms or physiological systems through the simultaneous use of genomics, informatics, & physiological analysis. Analysis of genes, expression, or proteomic profiles, recombination mapping, genomic comparison & complex phenotyping to identify those genes influencing complex physiological pathways. Assays for molecular interactions, natural & directed gene alteration, selective breeding studies, or cloning techniques that enable nuclear reprogramming, gene identification or the assessment of gene/environment interactions important to fundamental biochemical pathways. Computational & informatic approaches to integrative models, biomedical data analysis, or mathematical predictions to understand gene-influenced physiological function. Translational observations & interpretation of results important to medical application.
Protein Chemistry & Proteomics	Analysis of protein-protein interactions Folding Modification Novel drug targets Protein arrays Protein design Protein expression & secretion Protein expression mapping Protein separation & identification
Renal Pharmacology	Antihypertensive drugs in renal disease Diuretics/antidiuretics Drugs affecting renal blood flow Drugs for calcium & phosphate metabolism Drugs for inflammation Drugs to prevent acute and/or chronic renal failure Drugs used during dialysis Immunosuppressive drugs in renal disease Nephrotoxicity Regulation by peptides/neurotransmitters Renal drug excretion Treatment of anemia in renal failure
Respiratory Pharmacology	Altitude respiratory physiology Clinical pulmonary immunopharmacology COPD clinical and pharmacology COPD pharmacology, pathology & genetics Neonatal respiratory physiology Respiratory pharmacology Respiratory physiology, lung regeneration
Small Molecule Chemistry	Combinatorial chemistry Discovery of natural products Lead optimisation Natural product biosynthesis Novel enzyme co-factors & mechanistic probes Screening technologies Structure based drug design
Toxicology	Adverse effects of pesticides & industrial chemicals Adverse or toxic effects of drugs Environmental toxins Molecular pharmacology

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