SECTION	SCOPE
Antimicrobial Agents	Adjuncts for anti-microbial therapy (e.g. anti-penicillinase, renal excretion modifiers etc) Anti-bacterial agents Anti-parasite/anti-malarials Anti-viral agents Clinical properties of anti-microbial agents Resistance to anti-microbial agents
Autoimmunity	Breakdown in tolerance Environmental contribution Etiology & pathogenesis Genetics of autoimmunity Organ specific autoimmunity Systemic autoimmunity Therapy
Cancer Therapeutics	Cancer immunology & interaction with anticancer agents Identification of molecular targets for therapy (e.g. malignant cells & blood vessels) Mechanisms of drug action Targets for chemoprevention
Cardiovascular Pharmacology	Arrhythmias Atherosclerosis Cardiovascular risk factors Congestive heart failure Dyslipidemia Hypertension Hypotension Inflammation
Cardiovascular Physiology/Circulation	Blood Blood-brain barrier Capillary filtration Electrophysiology, micro circulation, hemodynamics, peripheral circulation, mechanical, neural & hormonal regulation & control Erythropoiesis Heart & myocardium Hemostasis & wound repair Lymphatic system, immunological impact on physiological function Regulation of blood pressure Regulation of blood pressure & heart rate
Cell Growth & Division	Cell cycle & proteolysis Cell cycle modelling Cell cycle protein structure Checkpoints Cyclin Cdk regulation/Cdk inhibitors DNA replication G1 progression G1/S G2/M Growth Control Meiotic maturation & meiosis Mitosis Mitotic exit & cytokinesis Nutrient sensing & the cell cycle Positive & negative receptor signalling to the cell cycle Simple metazoan cell cycle Telomeres, centromeres & centrosome/spindle pole body Transcriptome analysis, nutritional sensing & the cell cycle
Drug Discovery & Design	Combinatorial chemistry Drug approval & regulatory aspects High-throughput screening In-silico drug design Medicinal chemistry Pharmacoeconomics Structure-activity relationships Target discovery & validation
Endocrine & Metabolic Pharmacology	Anti-diabetes therapy Cholesterol lowering drugs Hormonal agonists & antagonists Steroids/body building Therapy for calcium disorders Therapy for other endocine/metabolic disorders Therapy for thyroid disorders Treatment of eating disorders (including obesity) Vitamin therapy & dietry supplements
Endocrinology	Adrenal medulla & cortex Biosynthesis & biodegradation of hormones Endocrine control of calcium Endocrine functions of pineal, heart, kidneys Endocrine pancreas & regulation of metabolism of carbohydrates, proteins & lipids Glucocorticoids & mineralocorticoids Humoral regulation of the cardiovascular system Hypothalamo-pituitary system Mechanisms of hormone action Regulation, secretion & metabolic effects of insulin Secretion & effects of nitric oxide Thyroidal hormones Transport of hormones in the blood
Gastrointestinal Pharmacology	Anti-inflammatories Constipation Diarrhoea Drugs for hepatic disorders Functional bowel disease: diarrhoea, constipation Functional bowel disease: nausea and abdominal pain Gastroparesis Gut wall absorption of drugs Incontinence Infections of GI tract Therapy of gastric acidity disorders Therapy of inflammatory bowel disease
Gastrointestinal Physiology	Absorption (intestine, colon) Digestion (carbohydrates, proteins/peptides, lipids) Enteric neurophysiology including neural inflammation Intestinal immunosystem Microorganisms in the intestinal tract Satiety Secretion (salivary glands, stomach, pancreas, liver) Smooth muscle & interstitial cells of Cajal electrophysiology Smooth muscle cell signaling Swallowing & transport of nutrients, motility, neuronal & hormonal regulation (esophagus, stomach, intestine, colon, defecation, vomiting)
Genito-Urinary & Reproductive Pharmacology	Contraception Drugs used during pregnancy Infertility & fertility drugs Menstruation/menopause Sexual dysfunction Testosterone replacement & therapy Therapy for lower urinary tract disorders Therapy for prostate & penile disorders Therapy for uterine disorders
Immunomodulation	Antigen barriers to transplantation Immunomodulation (including immunotherapy) Immunosuppression Mechanisms of graft rejection & GVHD Tumour evasion of immune system Tumour vaccines Vaccination (including therapeutic & contraceptive vaccines) Xenotransplantation
Immunopharmacology & Hematologic Pharmacology	Anemias Anti-allergy drugs Anti-inflammatory drugs Cytokines as drug targets Disorders of leukocytes (other than cancer) Immunomodulating agents Immunotherapy & vaccines Immunotoxicology Platelet disorders
Integrative Physiology	Aerospace & gravitational physiology Aging Biological clocks/chronophysiology Cell population control Clinical pathophysiology Exercise & training Fight & flight response General physiology: transport, reaction, receptors, water in cells & tissues Genomics to physiology Homeostasis & negative feedback control Intermediary metabolism/energy balance Methods in physiology Model databasing & archiving Modeling of integrative physiological systems Neurohumoral regulation (regulation of cardiovascular system, respiration, sleep, thirst & satiety, body temperature, fluid & electrolyte balance, stress, & body weight) Optical & other methods applied to in vivo physiology Physiological databasing Regulation of cells at tissue/organ level Responses to stress (eg hypoxia, hypothermia, heat shock/chaperones) Statistics of physiological experiment design Theoretical biology
Medical Genetics	Complex & simple gene mapping Gene therapy Genetic basis of diseases Pre-/post-natal diagnosis
Medical Microbiology	Diagnosis Epidemiology Gene regulation & variability Molecular taxonomy Molecular virology Pathogenicity mechanisms Resistance mechanisms animal models Symbiosis & infections The link between infection & diseases originally not considered infectious (atherosclerosis, stomach cancer, MS, diabetes, autism, etc.) Vaccines
Molecular Pharmacology	Ligands (agonists/antagonists) Signal transduction mechanisms (g proteins, kinases/phosphatases, calcium) Molecular modeling & databases Receptors (gpcrs, tyrosine kinases, ion channels nuclear vs cytoplasmic etc) Structure-function of important drug classes
Muscle & Connective Tissue	Bone remodeling, osteoblasts, osteoclasts Hair Ligaments Mechanism of contraction: E-C coupling, contactile proteins, cellular/contraction Muscle adaptation Muscle damage, satellite cells Muscle extra cellular matrix/collagen Muscle fibre types Muscle metabolism Muscle microcirculation Nails Teeth Tendons
Musculoskeletal & Dermatologic Pharmacology	Drugs for muscle/connective tissue Drugs for bone disorders (eg osteoporosis) Drugs for skin conditions (eg acne, anti-wrinkle creams, botox etc)
Neural Homeostasis	Autonomic nervous system Autonomic neurons & control, transmitter effects of neuropeptides Central control of autonomic function (cardiorespiratory integration, posterior pituitary function, osmoregulation, thermoregulation) Clinical dysautonomias Enteric nervous system Neural control of cardiovascular, respiratory & renal systems (circulation, breathing, sodium & osmoregulation) Neural control of energy balance & metabolism Neuroendocrine regulation (gonadal, adrenal, GnRH, hypothalamus, control of reproduction, estrogen effects on neurophysiology & behavior, neuroendocrinology of aging) Peripheral regulation (heart-rate variability, physiological consequences of psychopathology - eg hostility, Type A personality) Reticular formation Sleep cycle & circadian rhythms Stress (effects, responses & consequences), with relation to neurogenesis, development, maternal behavior, social behavior, aging, cognitive function, self-esteem, physiological consequences, & neuropsychology
Neurobiology of Disease & Regeneration	Cell death Developing & aging brain Mechanisms of neurological & psychiatric diseases Neuroimmunology/infections/prions Neuronal excitability Repair/response to injury Stem cells/cell therapy Transplantation
Neuropharmacology & Psychopharmacology	Analgesics Anti-epileptic drugs Blockers of transmitter synthesis, storage, uptake Bockers of neuroexcitation Chronopharmacology Drugs for cerebrovascular disease Drugs for eye disorders Drugs for learning & attention disorders Drugs for motor disorders Drugs for psychiatric disorders Drugs of abuse Sensory pharmacology (other than eye)
Pharmacogenomics	Comparative (evolutionary) pharmacology Genetic factors influencing pharmacodynamics Genetic factors influencing pharmacokinetics Genetically identified drug targets (e.g. orphan receptors) Genetic screening Tailoring drugs to individuals/populations
Pharmacokinetics & Drug Delivery	Bioavailability, drug distribution, metabolism (phase I and phase II enzymes) & excretion Drug delivery (including gene therapy & stem cells as delivery systems; blood-brain barrier) Drug interactions Pharmacokinetics Therapeutic drug monitoring
Physiogenomics	Scope: Approaches, results & interpretation that integrate molecular information for whole organisms or physiological systems through the simultaneous use of genomics, informatics, & physiological analysis. Analysis of genes, expression, or proteomic profiles, recombination mapping, genomic comparison & complex phenotyping to identify those genes influencing complex physiological pathways. Assays for molecular interactions, natural & directed gene alteration, selective breeding studies, or cloning techniques that enable nuclear reprogramming, gene identification or the assessment of gene/environment interactions important to fundamental biochemical pathways. Computational & informatic approaches to integrative models, biomedical data analysis, or mathematical predictions to understand gene-influenced physiological function. Translational observations & interpretation of results important to medical application.
Renal, Fluid & Electrolyte Physiology	Body fluids & electrolytes Renal hormones & autacoids Tubular function Ureter & bladder Micturition Vascular biology & glomelural filtration
Reproductive Physiology	Menstrual cycle Physiology of the breast including lactation Pregnancy (maternal adaptive responses) Puberty & menopause Sex differentiation & determination Sex hormones Sexual organs/accessory glands of reproduction The fetus The gonads The placenta & parturition
Respiratory physiology	Airway/epithelial biology/physiology Comparative respiratory physiology Environmental effects on the lungs (altitude, microgravity, hyperbaria) Exercise & the lungs Gas exchange & transport Neural & chemical regulation & control Pulmonary circulation Respiratory mechanics Vascular/endothelial biology/physiology
Stem Cells & Regeneration	Embryonic stem cells and pluripotency Mammalian tissue stem cells Model system stem cells Stem cells and disease (including cancer)
Toxicology	Adverse effects of pesticides & industrial chemicals Adverse or toxic effects of drugs Environmental toxins Molecular pharmacology

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