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 | Rolf Apweiler
| | | No longer a member of F1000[ 21-JUN-2001 - 26-JAN-2006 ] |
| | [ Biography ] [ Homepage ] [ Evaluations ] | Biography
Contact details:
EMBL Outstation - European Bioinformatics Institute
Wellcome Trust Genome Campus
Hinxton, Cambridge CB10 1SD, UK
Phone: +44 (0)1223 494435
Fax: +44 (0)1223 494468
E-mail: apweiler@ebi.ac.uk
Research Interest
One of the most important projects of the EMBL Outstation in Hinxton is the production of the SWISS-PROT + TrEMBL protein sequence database. SWISS-PROT is maintained collaboratively by Amos Bairoch from the Swiss Institute of Bioinformatics (SIB) and the European Bioinformatics Institute (EBI). In 1996 the EBI introduced TrEMBL as a supplement to SWISS-PROT containing computer-annotated translations of all coding sequences in the EMBL nucleotide sequence database, which are not yet in SWISS-PROT.
SWISS-PROT + TrEMBL represent the most complete and up-to-date protein sequence database with the lowest degree of redundancy and the highest standard of annotation publicly available today. We are, in collaboration with many other groups both in academia and industry, currently developing new procedures to speed up sequence analysis and data integration into SWISS-PROT + TrEMBL as well as elimination of redundancy.
The goal of my group is to provide the scientific community a complete, up-to-date, non-redundant protein sequence database with a high level of integration with other databases. To achieve this goal we need to develop new techniques to enhance the production of SWISS-PROT + TrEMBL. To cope with the flood of sequence and functional data, we are currently developing new methods to accelerate sequence analysis, information acquisition and data integration by automating and combining similarity searches, motif searches, special sequence analysis tools, and parsing of verified information from related biomolecular databases. This again gets combined with the development of a knowledgebase to add annotation to sequences.
| Home page
http://www.ebi.ac.uk/swissprot/ |
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