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John Imig
Cardiovascular Research Center, Medical College of Wisconsin, Milwaukee, United States of America

Faculty Member: Physiology > Renal, Fluid & Electrolyte Physiology [ since 20 November 2006 ]
[ Biography ] [ Homepage ] [ Evaluations ]
Biography

Dr. John D. Imig is a Professor in the Vascular Biology Center and Department of Physiology at the Medical College of Georgia. He has won numerous awards for his research in cardiovascular and renal physiology and recently received an Established Investigator Award from the American Heart Association. Dr. Imig¿s research has been continuously funded since 1992 by the National Institutes of Health and the American Heart Association. He earned his B.A. degree in biology from Blackburn College in 1985 and he received a Ph.D. in Physiology and Biophysics in 1990 from the University of Louisville. Dr. Imig moved to the Medical College of Wisconsin for postdoctoral training and accepted a faculty position in the Department of Physiology at Tulane University School of Medicine in 1993. He moved to his current position at the Medical College of Georgia in 2001. Dr. Imig has authored numerous peer reviewed manuscripts related to the anti-hypertensive and renal and cardiovascular protective properties of epoxygenase metabolites and epoxide hydrolase inhibitors. He serves on editorial boards for scientific journals of the American Physiological Society and American Heart Association and he serves on many study sections including the American Heart Association Cardiovascular Regulation Study Section.

Home page

http://www.mcg.edu/centers/VBC/vbc_bio_jimig.html

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Evaluations

Failure to upregulate the adenosine 2A receptor-epoxyeicosatrienoic acid pathway contributes to the development of hypertension in Dahl salt-sensitive rats.
Liclican EL, McGiff JC, Falck JR, Carroll MA
Am J Physiol Renal Physiol 2008 Oct 1 [abstract on PubMed] [related articles] [full text]
Selected by | John Imig
Evaluated 17 Oct 2008

Deletion of transient receptor potential vanilloid type 1 receptors exaggerates renal damage in deoxycorticosterone acetate-salt hypertension.
Wang Y, Babánková D, …, Swain GM, Wang DH
Hypertension 2008 Aug 52(2):264-70 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | John Imig
Evaluated 11 Aug 2008

IL-6/IL-6R axis plays a critical role in acute kidney injury.
Nechemia-Arbely Y, Barkan D, …, Galun E, Axelrod JH
J Am Soc Nephrol 2008 Jun 19(6):1106-15 [abstract on PubMed] [related articles] [FREE full text]
Selected by | John Imig
Evaluated 4 Jun 2008

Oral Delivery of 1,3-Dicyclohexylurea Nanosuspension Enhances Exposure and Lowers Blood Pressure in Hypertensive Rats.
Ghosh S, Chiang PC, …, Selbo JG, Roberds SL
Basic Clin Pharmacol Toxicol 2008 Feb 29 0 [abstract on PubMed] [related articles] [full text]
Selected by | John Imig
Evaluated 20 Mar 2008

20-Hydroxyeicosatetraenoic acid stimulates nuclear factor-kappaB activation and the production of inflammatory cytokines in human endothelial cells.
Ishizuka T, Cheng J, …, Falck JR, Laniado-Schwartzman M
J Pharmacol Exp Ther 2008 Jan 324(1):103-10 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | John Imig
Evaluated 22 Jan 2008

Pioglitazone exerts protective effects against stroke in stroke-prone spontaneously hypertensive rats, independently of blood pressure.
Nakamura T, Yamamoto E, …, Ogawa H, Kim-Mitsuyama S
Stroke 2007 Nov 38(11):3016-22 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | John Imig
Evaluated 15 Oct 2007

Vascular cytochrome P450 4A expression and 20-hydroxyeicosatetraenoic acid synthesis contribute to endothelial dysfunction in androgen-induced hypertension.
Singh H, Cheng J, …, Nasjletti A, Schwartzman ML
Hypertension 2007 Jul 50(1):123-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | John Imig
Evaluated 17 Aug 2007

Angiotensin II up-regulates soluble epoxide hydrolase in vascular endothelium in vitro and in vivo.
Ai D, Fu Y, …, Shyy JY, Zhu Y
Proc Natl Acad Sci U S A 2007 May 22 104(21):9018-23 [abstract on PubMed] [related articles] [FREE full text]
Selected by | John Imig
Evaluated 5 Jun 2007

Characterization of 14,15-epoxyeicosatrienoyl-sulfonamides as 14,15-epoxyeicosatrienoic acid agonists: use for studies of metabolism and ligand binding.
Yang W, Holmes BB, …, Falck JR, Campbell WB
J Pharmacol Exp Ther 2007 Jun 321(3):1023-31 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | John Imig
Evaluated 27 Mar 2007

Elevations in renal interstitial hydrostatic pressure and 20-hydroxyeicosatetraenoic acid contribute to pressure natriuresis.
Williams JM, Sarkis A, …, Flasch AK, Roman RJ
Hypertension 2007 Mar 49(3):687-94 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | John Imig
Evaluated 16 Feb 2007

Inability to upregulate cytochrome P450 4A and 2C causes salt sensitivity in young Sprague-Dawley rats.
Sankaralingam S, Desai KM, …, Kim RB, Wilson TW
Am J Hypertens 2006 Nov 19(11):1174-80 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | John Imig
Evaluated 19 Dec 2006

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