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Ken Irvine
Department of Molecular Biology and Biochemistry, Rutgers University, State University of New Jersey, Piscataway, United States of America

Faculty Member: Developmental Biology > Developmental Molecular Mechanisms [ since 26 September 2002 ]
[ Homepage ] [ Evaluations ]
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Evaluations

Alternative isoform regulation in human tissue transcriptomes.
Wang ET, Sandberg R, …, Schroth GP, Burge CB
Nature 2008 Nov 2 456(7221):470-476 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Ken Irvine with Yongqiang Feng / Donald Rio
Evaluated 20 Nov 2008

Chemical control of protein stability and function in living mice.
Banaszynski LA, Sellmyer MA, …, Wandless TJ, Thorne SH
Nat Med 2008 Oct 14(10):1123-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Ken Irvine with Yongqiang Feng / Thomas W. von Geldern
Evaluated 20 Nov 2008

The DHHC palmitoyltransferase approximated regulates Fat signaling and Dachs localization and activity.
Matakatsu H, Blair SS
Curr Biol 2008 Sep 23 18(18):1390-5 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Ken Irvine / David Strutt
Evaluated 30 Sep 2008

Reciprocal roles for bowl and lines in specifying the peripodial epithelium and the disc proper of the Drosophila wing primordium.
Nusinow D, Greenberg L, Hatini V
Development 2008 Sep 135(18):3031-41 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Ken Irvine
Evaluated 15 Sep 2008

Loss of Fat4 disrupts PCP signaling and oriented cell division and leads to cystic kidney disease.
Saburi S, Hester I, …, Mount R, McNeill H
Nat Genet 2008 Jul 6 [abstract on PubMed] [related articles] [full text]
Selected by | David Strutt / Ken Irvine
Evaluated 18 Jul 2008


Endosomal entry regulates Notch receptor activation in Drosophila melanogaster.
Vaccari T, Lu H, …, Fortini ME, Bilder D
J Cell Biol 2008 Feb 25 180(4):755-62 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Ken Irvine
Evaluated 1 May 2008

A chemical method for fast and sensitive detection of DNA synthesis in vivo.
Salic A, Mitchison TJ
Proc Natl Acad Sci U S A 2008 Feb 19 105(7):2415-20 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Andy Groves / Fritz Eckstein / Ken Irvine / Stephen Kearsey / Lucio Comai
Evaluated 25 Feb 2008

Rumi Is a CAP10 Domain Glycosyltransferase that Modifies Notch and Is Required for Notch Signaling.
Acar M, Jafar-Nejad H, …, Haltiwanger RS, Bellen HJ
Cell 2008 132:247-258 [full text]
Selected by | Ken Irvine / Jane Hewitt / Andy Groves
Evaluated 29 Jan 2008

Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control.
Zhao B, Wei X, …, Lai ZC, Guan KL
Genes Dev 2007 Nov 1 21(21):2747-61 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Ken Irvine
Evaluated 26 Nov 2007

Global analysis of mRNA localization reveals a prominent role in organizing cellular architecture and function.
Lécuyer E, Yoshida H, …, Tomancak P, Krause HM
Cell 2007 Oct 5 131(1):174-87 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Talila Volk / Ken Irvine / Michael Sendtner / Elizabeth Gavis / Roy Long / Paul Lasko / Douglas Turner
Evaluated 22 Oct 2007

Recruitment of cells into the Drosophila wing primordium by a feed-forward circuit of vestigial autoregulation.
Zecca M, Struhl G
Development 2007 Aug 134(16):3001-10 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Laura Johnston / Ken Irvine
Evaluated 16 Aug 2007

Oriented cell divisions in the extending germband of Drosophila.
da Silva SM, Vincent JP
Development 2007 Sep 134(17):3049-54 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Ken Irvine
Evaluated 16 Aug 2007

Lipoprotein-heparan sulfate interactions in the Hh pathway.
Eugster C, Panáková D, Mahmoud A, Eaton S
Dev Cell 2007 Jul 13(1):57-71 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Ken Irvine
Evaluated 11 Jul 2007

Complex N-glycan number and degree of branching cooperate to regulate cell proliferation and differentiation.
Lau KS, Partridge EA, …, Demetriou M, Dennis JW
Cell 2007 Apr 6 129(1):123-34 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Ken Irvine / Lara Mahal
Evaluated 24 Apr 2007

Control of Drosophila gastrulation by apical localization of adherens junctions and RhoGEF2.
Kölsch V, Seher T, …, Serrano L, Leptin M
Science 2007 Jan 19 315(5810):384-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Manfred Frasch / Ken Irvine / Thomas Lecuit
Evaluated 26 Jan 2007

Structure of a heparin-dependent complex of Hedgehog and Ihog.
McLellan JS, Yao S, …, Beachy PA, Leahy DJ
Proc Natl Acad Sci U S A 2006 Nov 14 103(46):17208-13 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Mario Amzel / Ken Irvine / Simon Hughes
Evaluated 4 Dec 2006

Biological function of unannotated transcription during the early development of Drosophila melanogaster.
Manak JR, Dike S, …, Piccolboni A, Gingeras TR
Nat Genet 2006 Oct 38(10):1151-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Ken Irvine / Chris Ponting
Evaluated 6 Oct 2006

The emergence of geometric order in proliferating metazoan epithelia.
Gibson MC, Patel AB, Nagpal R, Perrimon N
Nature 2006 Aug 31 442(7106):1038-41 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jennifer Zallen / Laura Johnston / Thomas Lecuit / Ken Irvine / David Alpers
Evaluated 5 Oct 2006

A distinct small RNA pathway silences selfish genetic elements in the germline.
Vagin VV, Sigova A, …, Gvozdev V, Zamore PD
Science 2006 Jul 21 313(5785):320-4 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Ken Irvine
Evaluated 31 Jul 2006

The molecular diversity of Dscam is functionally required for neuronal wiring specificity in Drosophila.
Chen BE, Kondo M, …, Lamar DR, Schmucker D
Cell 2006 May 5 125(3):607-20 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Ken Irvine / Joachim Kurtz / Silvia Arber
Evaluated 10 May 2006

Palmitoylation of the EGFR ligand Spitz by Rasp increases Spitz activity by restricting its diffusion.
Miura GI, Buglino J, …, Resh MD, Treisman JE
Dev Cell 2006 Feb 10(2):167-76 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Ben Zion Shilo / Ross Cagan / Ken Irvine
Evaluated 20 Mar 2006

Polarized transport of Frizzled along the planar microtubule arrays in Drosophila wing epithelium.
Shimada Y, Yonemura S, …, Strutt D, Uemura T
Dev Cell 2006 Feb 10(2):209-22 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jeffrey Axelrod / Ken Irvine
Evaluated 2 Mar 2006

Hexagonal packing of Drosophila wing epithelial cells by the planar cell polarity pathway.
Classen AK, Anderson KI, Marois E, Eaton S
Dev Cell 2005 Dec 9(6):805-17 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Ken Irvine / Thomas Lecuit
Evaluated 14 Dec 2005

The heparan sulfate proteoglycan syndecan is an in vivo ligand for the Drosophila LAR receptor tyrosine phosphatase.
Fox AN, Zinn K
Curr Biol 2005 Oct 11 15(19):1701-11 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | John Couchman / Ken Irvine
Evaluated 30 Nov 2005

Distinct functional units of the Golgi complex in Drosophila cells.
Yano H, Yamamoto-Hino M, …, Toyoda H, Goto S
Proc Natl Acad Sci U S A 2005 Sep 20 102(38):13467-72 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Catherine Rabouille / Ken Irvine
Evaluated 17 Nov 2005

The orientation of cell divisions determines the shape of Drosophila organs.
Baena-López LA, Baonza A, García-Bellido A
Curr Biol 2005 Sep 20 15(18):1640-4 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jessica E. Treisman / Ken Irvine / Jonathan Slack
Evaluated 6 Oct 2005

Regulators of endocytosis maintain localized receptor tyrosine kinase signaling in guided migration.
Jékely G, Sung HH, Luque CM, Rørth P
Dev Cell 2005 Aug 9(2):197-207 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Paul Lasko / Ken Irvine / Jessica E. Treisman / Jean-Paul Vincent / Catherine Rabouille / Michael Roth
Evaluated 19 Aug 2005

Antisense-mediated depletion reveals essential and specific functions of microRNAs in Drosophila development.
Leaman D, Chen PY, …, Tuschl T, Gaul U
Cell 2005 Jul 1 121(7):1097-108 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Fritz Eckstein / Detlef Weigel / Ken Irvine / Thomas Lecuit
Evaluated 1 Aug 2005

Lipoprotein particles are required for Hedgehog and Wingless signalling.
Panáková D, Sprong H, …, Thiele C, Eaton S
Nature 2005 May 5 435(7038):58-65 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Bruce Morgan / Ken Irvine / Marta Llimargas / Deborah Andrew
Evaluated 9 May 2005

Nuclear localization is required for Dishevelled function in Wnt/beta-catenin signaling.
Itoh K, Brott BK, …, Ratcliffe MJ, Sokol SY
J Biol 2005 4(1):3 [abstract on PubMed] [related articles] [FREE full text]
Selected by | David Kimelman / Herbert Steinbeisser / Ken Irvine / Murray Stewart / Avri Ben-Ze'ev / Inke Nathke
Evaluated 9 Mar 2005

A homologue of the Drosophila kinesin-like protein Costal2 regulates Hedgehog signal transduction in the vertebrate embryo.
Tay SY, Ingham PW, Roy S
Development 2005 Feb 132(4):625-34 [abstract on PubMed] [related articles] [FREE full text]
Selected by | James Briscoe / Ken Irvine
Evaluated 2 Feb 2005

Drosophila Dpp morphogen movement is independent of dynamin-mediated endocytosis but regulated by the glypican members of heparan sulfate proteoglycans.
Belenkaya TY, Han C, …, Liu H, Lin X
Cell 2004 Oct 15 119(2):231-44 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Andrew Lumsden / Ken Irvine / Deborah Andrew / Jean-Paul Vincent / Jeffrey Axelrod / Alain Prochiantz
Dissenters | Alfonso Martinez Arias
Author Response | Xinhua Lin
Evaluated 1 Nov 2004


Compensatory proliferation induced by cell death in the Drosophila wing disc requires activity of the apical cell death caspase Dronc in a nonapoptotic role.
Huh JR, Guo M, Hay BA
Curr Biol 2004 Jul 27 14(14):1262-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Sharad Kumar / Ken Irvine
Evaluated 27 Aug 2004

Patterned gene expression directs bipolar planar polarity in Drosophila.
Zallen JA, Wieschaus E
Dev Cell 2004 Mar 6(3):343-55 [abstract on PubMed] [related articles] [order article]
Selected by | Jeffrey Axelrod / Ken Irvine / Deborah Andrew / Maria Leptin
Evaluated 13 Apr 2004

Rac-dependent trans-endocytosis of ephrinBs regulates Eph-ephrin contact repulsion.
Marston DJ, Dickinson S, Nobes CD
Nat Cell Biol 2003 Oct 5(10):879-88 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Ken Irvine
Evaluated 30 Jan 2004

EphB-ephrinB bi-directional endocytosis terminates adhesion allowing contact mediated repulsion.
Zimmer M, Palmer A, Köhler J, Klein R
Nat Cell Biol 2003 Oct 5(10):869-78 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Vance Lemmon / Ken Irvine
Evaluated 30 Jan 2004

Notch activity acts as a sensor for extracellular calcium during vertebrate left-right determination.
Raya A, Kawakami Y, …, Feijó JA, Izpisúa Belmonte JC
Nature 2004 Jan 8 427(6970):121-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Raphael Kopan / Ken Irvine / David Ish-Horowicz / Alfonso Martinez Arias
Evaluated 30 Jan 2004

Delta-promoted filopodia mediate long-range lateral inhibition in Drosophila.
De Joussineau C, Soulé J, …, Montcourrier P, Alexandre D
Nature 2003 Dec 4 426(6966):555-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Geoffrey A. Manley / Daniel Constam / Silvia Arber / Mark Fortini / Ken Irvine / Judith S. Eisen / Jeffrey Axelrod
Evaluated 23 Dec 2003

The Drosophila sterile-20 kinase slik controls cell proliferation and apoptosis during imaginal disc development.
Hipfner DR, Cohen SM
PLoS Biol 2003 Nov 1(2):E35 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Ken Irvine
Evaluated 16 Dec 2003

A functional genomic analysis of cell morphology using RNA interference.
Kiger AA, Baum B, …, Echeverri C, Perrimon N
J Biol 2003 2(4):27 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Oliver Hobert / Craig Montell / Ken Irvine / David Bilder
Evaluated 16 Dec 2003

A nutrient sensor mechanism controls Drosophila growth.
Colombani J, Raisin S, …, Montagne J, Léopold P
Cell 2003 Sep 19 114(6):739-49 [abstract on PubMed] [related articles] [order article]
Selected by | Sally Leevers / Peter Taylor / Michael Hall / Peter Gallant / Ken Irvine
Evaluated 12 Nov 2003

scribble mutants cooperate with oncogenic Ras or Notch to cause neoplastic overgrowth in Drosophila.
Brumby AM, Richardson HE
EMBO J 2003 Nov 3 22(21):5769-79 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Ken Irvine / Valeri Vasioukhin
Evaluated 6 Nov 2003

Transport of dsRNA into cells by the transmembrane protein SID-1.
Feinberg EH, Hunter CP
Science 2003 Sep 12 301(5639):1545-7 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Ken Irvine
Evaluated 16 Sep 2003

The small RNA profile during Drosophila melanogaster development.
Aravin AA, Lagos-Quintana M, …, Meyer J, Tuschl T
Dev Cell 2003 Aug 5(2):337-50 [abstract on PubMed] [related articles] [order article]
Selected by | Ken Irvine / Marjori Matzke / Frank Lyko
Evaluated 20 Aug 2003

Numb inhibits membrane localization of Sanpodo, a four-pass transmembrane protein, to promote asymmetric divisions in Drosophila.
O'Connor-Giles KM, Skeath JB
Dev Cell 2003 Aug 5(2):231-43 [abstract on PubMed] [related articles] [order article]
Selected by | Manfred Frasch / Ken Irvine / Valeri Vasioukhin / Talila Volk / Bill Chia
Evaluated 20 Aug 2003

Two subunits of the Drosophila mediator complex act together to control cell affinity.
Janody F, Martirosyan Z, Benlali A, Treisman JE
Development 2003 Aug 130(16):3691-701 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Ken Irvine
Evaluated 22 Jul 2003

Integrin-ECM interactions regulate cadherin-dependent cell adhesion and are required for convergent extension in Xenopus.
Marsden M, DeSimone DW
Curr Biol 2003 Jul 15 13(14):1182-91 [abstract on PubMed] [related articles] [order article]
Selected by | Ken Irvine / Jean Schwarzbauer / Inke Nathke
Evaluated 21 Jul 2003

Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta.
Itoh M, Kim CH, …, Chandrasekharappa SC, Chitnis AB
Dev Cell 2003 Jan 4(1):67-82 [abstract on PubMed] [related articles] [order article]
Selected by | David Kimelman / Judith S. Eisen / Manfred Frasch / Ken Irvine
Evaluated 16 May 2003

The tumor-suppressor and cell adhesion molecule Fat controls planar polarity via physical interactions with Atrophin, a transcriptional co-repressor.
Fanto M, Clayton L, …, Kerridge S, McNeill H
Development 2003 Feb 130(4):763-74 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Ken Irvine / Jeffrey Axelrod
Evaluated 25 Feb 2003

Down-regulation of Delta by proteolytic processing.
Mishra-Gorur K, Rand MD, Perez-Villamil B, Artavanis-Tsakonas S
J Cell Biol 2002 Oct 28 159(2):313-24 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Ken Irvine
Evaluated 7 Jan 2003

Hephaestus encodes a polypyrimidine tract binding protein that regulates Notch signalling during wing development in Drosophila melanogaster.
Dansereau DA, Lunke MD, …, Russell MA, Brook WJ
Development 2002 Dec 129(24):5553-66 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Ken Irvine
Evaluated 3 Jan 2003

The endocytic protein alpha-Adaptin is required for numb-mediated asymmetric cell division in Drosophila.
Berdnik D, Török T, González-Gaitán M, Knoblich JA
Dev Cell 2002 Aug 3(2):221-31 [abstract on PubMed] [related articles] [order article]
Selected by | Ken Irvine
Evaluated 26 Nov 2002

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