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Daniel Weeks
Department of Human Genetics, University of Pittsburgh, Pittsburgh, United States of America

Faculty Member: Genomics & Genetics > Medical Genetics [ since 9 July 2001 ]
[ Biography ] [ Homepage ] [ Evaluations ]
Biography

Dr. Weeks received his Ph.D. in Biomathematics from UCLA in 1988, under the mentorship of Kenneth Lange. After post-doctoral training in statistical genetics with Jurg Ott at Columbia University, he joined the Department of Human Genetics at the University of Pittsburgh in 1990. From 1994-1998, he served as Head of Statistical Genetics - Methods at the Wellcome Trust Centre for Human Genetics at the University of Oxford. His research focuses on developing new ways to map susceptibility genes involved in genetically complex diseases. He has made significant contributions to methodology development in statistical genetics as well as participated in applied collaborative linkage analyses of many diseases, including autism, diabetes, endometriosis, and age-related macular degeneration. He has also been active in developing and distributing many useful computer programs, including ones for simulation, linkage analysis, and error detection. He has served on the editorial boards of the American Journal of Human Genetics, Human Molecular Genetics, and Genetic Epidemiology, and is active in education, both within his institution, where he is Program Director of a Statistical Genetics Training Program, and outside, where, for example, he co-leads an annual Wellcome Trust Advanced Course in statistical genetics.

Home page

http://watson.hgen.pitt.edu

to email [Help]
Evaluations

Resolving individuals contributing trace amounts of DNA to highly complex mixtures using high-density SNP genotyping microarrays.
Homer N, Szelinger S, …, Nelson SF, Craig DW
PLoS Genet 2008 Aug 4(8):e1000167 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Daniel Weeks
Evaluated 5 Sep 2008

A complete classification of epistatic two-locus models.
Hallgrímsdóttir IB, Yuster DS
BMC Genet 2008 9:17 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Daniel Weeks
Evaluated 27 May 2008

Integrating the Predictiveness of a Marker with Its Performance as a Classifier.
Pepe MS, Feng Z, …, Thompson IM, Zheng Y
Am J Epidemiol 2007 Nov 2 [abstract on PubMed] [related articles] [full text]
Selected by | Daniel Weeks
Evaluated 17 Dec 2007

Limitations of the odds ratio in gauging the performance of a diagnostic, prognostic, or screening marker.
Pepe MS, Janes H, …, Leisenring W, Newcomb P
Am J Epidemiol 2004 May 1 159(9):882-90 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Daniel Weeks
Evaluated 7 Jun 2007


Using HapMap data: a cautionary note.
Biswas NK, Dey B, Majumder PP
Eur J Hum Genet 2007 Feb 15(2):246-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Daniel Weeks
Evaluated 4 Jan 2007

An alternative foundation for the planning and evaluation of linkage analysis. II. Implications for multiple test adjustments.
Strug LJ, Hodge SE
Hum Hered 2006 61(4):200-9 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Daniel Weeks
Evaluated 23 Oct 2006

An alternative foundation for the planning and evaluation of linkage analysis. I. Decoupling "error probabilities" from "measures of evidence".
Strug LJ, Hodge SE
Hum Hered 2006 61(3):166-88 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Daniel Weeks
Evaluated 23 Oct 2006

No evidence for association with Parkinson disease for 13 single-nucleotide polymorphisms identified by whole-genome association screening.
Goris A, Williams-Gray CH, …, Barker RA, Sawcer SJ
Am J Hum Genet 2006 Jun 78(6):1088-90; author reply 1092-4 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Daniel Weeks
Evaluated 25 Apr 2006

Conflicting results regarding the semaphorin gene (SEMA5A) and the risk for Parkinson disease.
Clarimon J, Scholz S, …, Tienari PJ, Singleton A
Am J Hum Genet 2006 Jun 78(6):1082-4; author reply 1092-4 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Daniel Weeks
Evaluated 25 Apr 2006

A case-control association study of the 12 single-nucleotide polymorphisms implicated in Parkinson disease by a recent genome scan.
Li Y, Rowland C, …, Sninsky J, Grupe A
Am J Hum Genet 2006 Jun 78(6):1090-2; author reply 1092-4 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Daniel Weeks
Evaluated 25 Apr 2006

Genomewide association, Parkinson disease, and PARK10.
Farrer MJ, Haugarvoll K, …, Uitti RJ, Toft M
Am J Hum Genet 2006 Jun 78(6):1084-8; author reply 1092-4 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Daniel Weeks
Evaluated 25 Apr 2006

Cigarette smoking strongly modifies the association of LOC387715 and age-related macular degeneration.
Schmidt S, Hauser MA, …, Haines JL, Pericak-Vance MA
Am J Hum Genet 2006 May 78(5):852-64 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Daniel Weeks / Terri Beaty
Evaluated 30 Mar 2006

Genetically indistinguishable SNPs and their influence on inferring the location of disease-associated variants.
Lawrence R, Evans DM, …, Bentley D, Cardon LR
Genome Res 2005 Nov 15(11):1503-10 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Daniel Weeks
Evaluated 14 Nov 2005

Reproducible research: a bioinformatics case study.
Gentleman R
Stat Appl Genet Mol Biol 2005 4(1):Article2 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Daniel Weeks / Charles Auffray
Evaluated 8 Jul 2005

Case-control single-marker and haplotypic association analysis of pedigree data.
Browning SR, Briley JD, …, Yarnall DP, Wagner MJ
Genet Epidemiol 2005 Feb 28(2):110-22 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Daniel Weeks
Evaluated 11 May 2005

Exhaustive allelic transmission disequilibrium tests as a new approach to genome-wide association studies.
Lin S, Chakravarti A, Cutler DJ
Nat Genet 2004 Nov 36(11):1181-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Daniel Weeks
Evaluated 29 Nov 2004

Graphical modeling of the joint distribution of alleles at associated loci.
Thomas A, Camp NJ
Am J Hum Genet 2004 Jun 74(6):1088-101 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Daniel Weeks
Evaluated 11 Oct 2004

Gamma regression improves Haseman-Elston and variance components linkage analysis for sib-pairs.
Barber MJ, Cordell HJ, MacGregor AJ, Andrew T
Genet Epidemiol 2004 Feb 26(2):97-107 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Daniel Weeks
Evaluated 6 Oct 2004

Evidence for extensive transmission distortion in the human genome.
Zöllner S, Wen X, …, Ober C, Pritchard JK
Am J Hum Genet 2004 Jan 74(1):62-72 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Michael O'Donovan / Daniel Weeks
Evaluated 2 Mar 2004

Application of Bayesian spatial statistical methods to analysis of haplotypes effects and gene mapping.
Molitor J, Marjoram P, Thomas D
Genet Epidemiol 2003 Sep 25(2):95-105 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Daniel Weeks
Evaluated 13 Oct 2003

Inference of population structure using multilocus genotype data: linked loci and correlated allele frequencies.
Falush D, Stephens M, Pritchard JK
Genetics 2003 Aug 164(4):1567-87 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Daniel Weeks
Evaluated 30 Sep 2003

Genomic imprinting and linkage test for quantitative-trait Loci in extended pedigrees.
Shete S, Zhou X, Amos CI
Am J Hum Genet 2003 Oct 73(4):933-8 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Daniel Weeks
Evaluated 30 Sep 2003

Genetics of gene expression surveyed in maize, mouse and man.
Schadt EE, Monks SA, …, Stoughton RB, Friend SH
Nature 2003 Mar 20 422(6929):297-302 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Daniel Weeks / William Kaelin / Michael O'Donovan
Evaluated 14 May 2003

RHD maternal-fetal genotype incompatibility increases schizophrenia susceptibility.
Palmer CG, Turunen JA, …, Peltonen L, Woodward JA
Am J Hum Genet 2002 Dec 71(6):1312-9 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Daniel Weeks
Evaluated 12 Feb 2003

Hierarchical modeling of linkage disequilibrium: genetic structure and spatial relations.
Conti DV, Witte JS
Am J Hum Genet 2003 Feb 72(2):351-63 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Daniel Weeks
Evaluated 12 Feb 2003

Sampling distribution of summary linkage disequilibrium measures.
Teare MD, Dunning AM, …, Rennart G, Easton DF
Ann Hum Genet 2002 May 66(Pt 3):223-33 [abstract on PubMed] [related articles] [order article]
Selected by | Daniel Weeks
Evaluated 4 Nov 2002

Powerful regression-based quantitative-trait linkage analysis of general pedigrees.
Sham PC, Purcell S, Cherny SS, Abecasis GR
Am J Hum Genet 2002 Aug 71(2):238-53 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Daniel Weeks
Evaluated 9 Aug 2002

The structure of haplotype blocks in the human genome.
Gabriel SB, Schaffner SF, …, Daly MJ, Altshuler D
Science 2002 Jun 21 296(5576):2225-9 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Daniel Weeks / Michael O'Donovan
Evaluated 15 Jul 2002

A dynamic programming algorithm for haplotype block partitioning.
Zhang K, Deng M, …, Waterman MS, Sun F
Proc Natl Acad Sci U S A 2002 May 28 99(11):7335-9 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Daniel Weeks
Evaluated 12 Jul 2002

Tests for genetic association using family data.
Shih MC, Whittemore AS
Genet Epidemiol 2002 Feb 22(2):128-45 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Daniel Weeks
Evaluated 31 May 2002

Allele sharing and allelic association I: sib pair tests with increased power.
Lazzeroni LC
Genet Epidemiol 2002 Apr 22(4):328-44 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Daniel Weeks
Evaluated 31 May 2002

A perspective on epistasis: limits of models displaying no main effect.
Culverhouse R, Suarez BK, Lin J, Reich T
Am J Hum Genet 2002 Feb 70(2):461-71 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Jurg Ott / Daniel Weeks
Evaluated 4 Mar 2002

Detection and integration of genotyping errors in statistical genetics.
Sobel E, Papp JC, Lange K
Am J Hum Genet 2002 Feb 70(2):496-508 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Jurg Ott / Daniel Weeks / Alejandro Schaffer
Evaluated 25 Feb 2002

Bayesian haplotype inference for multiple linked single-nucleotide polymorphisms.
Niu T, Qin ZS, Xu X, Liu JS
Am J Hum Genet 2002 Jan 70(1):157-69 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Lon Cardon / Daniel Weeks
Evaluated 25 Feb 2002

Large upward bias in estimation of locus-specific effects from genomewide scans.
Göring HH, Terwilliger JD, Blangero J
Am J Hum Genet 2001 Dec 69(6):1357-69 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Daniel Weeks
Evaluated 21 Dec 2001

Merlin--rapid analysis of dense genetic maps using sparse gene flow trees.
Abecasis GR, Cherny SS, Cookson WO, Cardon LR
Nat Genet 2002 Jan 30(1):97-101 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Daniel Weeks / Alejandro Schaffer
Evaluated 20 Dec 2001

The Ising model in physics and statistical genetics.
Majewski J, Li H, Ott J
Am J Hum Genet 2001 Oct 69(4):853-62 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Daniel Weeks
Evaluated 20 Dec 2001

Sequence analysis using logic regression.
Kooperberg C, Ruczinski I, LeBlanc ML, Hsu L
Genet Epidemiol 2001 21 Suppl 1:S626-31 [abstract on PubMed] [related articles] [order article]
Selected by | Daniel Weeks
Evaluated 20 Dec 2001

The impact of genotyping error on family-based analysis of quantitative traits.
Abecasis GR, Cherny SS, Cardon LR
Eur J Hum Genet 2001 Feb 9(2):130-4 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Daniel Weeks
Evaluated 4 Oct 2001

Lower-than-expected linkage disequilibrium between tightly linked markers in humans suggests a role for gene conversion.
Ardlie K, Liu-Cordero SN, …, Lander ES, Kruglyak L
Am J Hum Genet 2001 Sep 69(3):582-9 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Daniel Weeks
Evaluated 24 Sep 2001

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