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Daniel Constam
Swiss Institute for Experimental Cancer Research (ISREC), Switzerland

Faculty Member: Developmental Biology > Developmental Molecular Mechanisms [ since 4 September 2002 ]
[ Evaluations ]
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Evaluations

The endoderm of the mouse embryo arises by dynamic widespread intercalation of embryonic and extraembryonic lineages.
Kwon GS, Viotti M, Hadjantonakis AK
Dev Cell 2008 Oct 15(4):509-20 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Daniel Constam
Evaluated 23 Oct 2008

Long-range action of Nodal requires interaction with GDF1.
Tanaka C, Sakuma R, …, Hamada H, Saijoh Y
Genes Dev 2007 Dec 15 21(24):3272-82 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Daniel Constam
Evaluated 22 Jan 2008

Disruption of intraflagellar transport in adult mice leads to obesity and slow-onset cystic kidney disease.
Davenport JR, Watts AJ, …, Kesterson RA, Yoder BK
Curr Biol 2007 Sep 18 17(18):1586-94 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jonathan Scholey / Daniel Constam / Arturo Alvarez-Buylla / Mary Porter
Evaluated 12 Nov 2007

The secreted serine protease xHtrA1 stimulates long-range FGF signaling in the early Xenopus embryo.
Hou S, Maccarana M, …, Strate I, Pera EM
Dev Cell 2007 Aug 13(2):226-41 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Daniel Constam / Alain Prochiantz
Evaluated 4 Sep 2007

The DIX domain of Dishevelled confers Wnt signaling by dynamic polymerization.
Schwarz-Romond T, Fiedler M, …, Higuchi Y, Bienz M
Nat Struct Mol Biol 2007 Jun 14(6):484-92 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Daniel Constam
Evaluated 21 Jun 2007

Association of Dishevelled with the clathrin AP-2 adaptor is required for Frizzled endocytosis and planar cell polarity signaling.
Yu A, Rual JF, …, He X, Kirchhausen T
Dev Cell 2007 Jan 12(1):129-41 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Daniel Constam
Evaluated 17 Jan 2007

Sara endosomes and the maintenance of Dpp signaling levels across mitosis.
Bökel C, Schwabedissen A, …, Renaud O, González-Gaitán M
Science 2006 Nov 17 314(5802):1135-9 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Daniel Constam
Evaluated 4 Dec 2006

Embryonic and tumorigenic pathways converge via Nodal signaling: role in melanoma aggressiveness.
Topczewska JM, Postovit LM, …, Topczewski J, Hendrix MJ
Nat Med 2006 Aug 12(8):925-32 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Daniel Constam
Evaluated 23 Aug 2006

Zebrafish endoderm formation is regulated by combinatorial Nodal, FGF and BMP signalling.
Poulain M, Fürthauer M, …, Thisse C, Lepage T
Development 2006 Jun 133(11):2189-200 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Daniel Constam
Evaluated 2 Jun 2006

Crossveinless 2 is an essential positive feedback regulator of Bmp signaling during zebrafish gastrulation.
Rentzsch F, Zhang J, …, Sebald W, Hammerschmidt M
Development 2006 Mar 133(5):801-11 [abstract on PubMed] [related articles] [FREE full text]
Selected by | David Kimelman / Daniel Constam
Evaluated 15 Mar 2006

Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function.
Haycraft CJ, Banizs B, …, Michaud EJ, Yoder BK
PLoS Genet 2005 Oct 1(4):e53 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Daniel Constam
Evaluated 17 Nov 2005

FGF signal interpretation is directed by Sprouty and Spred proteins during mesoderm formation.
Sivak JM, Petersen LF, Amaya E
Dev Cell 2005 May 8(5):689-701 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Kimelman / Daniel Constam
Evaluated 11 May 2005

Effect of conditional knockout of the type II TGF-beta receptor gene in mammary epithelia on mammary gland development and polyomavirus middle T antigen induced tumor formation and metastasis.
Forrester E, Chytil A, …, Muller WJ, Moses HL
Cancer Res 2005 Mar 15 65(6):2296-302 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Daniel Constam
Evaluated 13 Apr 2005

Germ-layer specification and control of cell growth by Ectodermin, a Smad4 ubiquitin ligase.
Dupont S, Zacchigna L, …, Rugge M, Piccolo S
Cell 2005 Apr 8 121(1):87-99 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Daniel Constam / Manfred Frasch / Herbert Steinbeisser
Evaluated 13 Apr 2005

XPACE4 is a localized pro-protein convertase required for mesoderm induction and the cleavage of specific TGFbeta proteins in Xenopus development.
Birsoy B, Berg L, …, Christian JL, Heasman J
Development 2005 Feb 132(3):591-602 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Daniel Constam
Evaluated 20 Jan 2005

Defective paracrine signalling by TGFbeta in yolk sac vasculature of endoglin mutant mice: a paradigm for hereditary haemorrhagic telangiectasia.
Carvalho RL, Jonker L, …, Arthur HM, Mummery CL
Development 2004 Dec 131(24):6237-47 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Daniel Constam
Evaluated 13 Jan 2005

Haemangioblast commitment is initiated in the primitive streak of the mouse embryo.
Huber TL, Kouskoff V, …, Palis J, Keller G
Nature 2004 Dec 2 432(7017):625-30 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Daniel Constam / Patrick Tam / Azim Surani / Roger Patient / Elaine Dzierzak
Evaluated 7 Dec 2004

Cleavages within the prodomain direct intracellular trafficking and degradation of mature bone morphogenetic protein-4.
Degnin C, Jean F, Thomas G, Christian JL
Mol Biol Cell 2004 Nov 15(11):5012-20 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Daniel Constam
Evaluated 16 Sep 2004

In vivo convergence of BMP and MAPK signaling pathways: impact of differential Smad1 phosphorylation on development and homeostasis.
Aubin J, Davy A, Soriano P
Genes Dev 2004 Jun 15 18(12):1482-94 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Daniel Constam / David Wotton / Claudio Stern
Evaluated 24 Jun 2004

Differential trafficking of transforming growth factor-beta receptors and ligand in polarized epithelial cells.
Murphy SJ, Doré JJ, …, Wilkes M, Leof EB
Mol Biol Cell 2004 Jun 15(6):2853-62 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Daniel Constam
Evaluated 27 Apr 2004

Integration of TGF-beta/Smad and Jagged1/Notch signalling in epithelial-to-mesenchymal transition.
Zavadil J, Cermak L, Soto-Nieves N, Böttinger EP
EMBO J 2004 Mar 10 23(5):1155-65 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Daniel Constam
Evaluated 8 Mar 2004

Hex homeobox gene-dependent tissue positioning is required for organogenesis of the ventral pancreas.
Bort R, Martinez-Barbera JP, Beddington RS, Zaret KS
Development 2004 Feb 131(4):797-806 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Daniel Constam
Evaluated 23 Feb 2004

Delta-promoted filopodia mediate long-range lateral inhibition in Drosophila.
De Joussineau C, Soulé J, …, Montcourrier P, Alexandre D
Nature 2003 Dec 4 426(6966):555-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Geoffrey A. Manley / Daniel Constam / Silvia Arber / Mark Fortini / Ken Irvine / Judith S. Eisen / Jeffrey Axelrod
Evaluated 10 Dec 2003

Hrs mediates downregulation of multiple signalling receptors in Drosophila.
Jékely G, Rørth P
EMBO Rep 2003 Dec 4(12):1163-8 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Daniel Constam
Evaluated 9 Dec 2003

Tomoregulin-1 (TMEFF1) inhibits nodal signaling through direct binding to the nodal coreceptor Cripto.
Harms PW, Chang C
Genes Dev 2003 Nov 1 17(21):2624-9 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Daniel Constam
Evaluated 23 Oct 2003

Self-enhanced ligand degradation underlies robustness of morphogen gradients.
Eldar A, Rosin D, Shilo BZ, Barkai N
Dev Cell 2003 Oct 5(4):635-46 [abstract on PubMed] [related articles] [order article]
Selected by | Daniel Constam / Jean-Paul Vincent
Evaluated 23 Oct 2003

Spatial and temporal patterns of ERK signaling during mouse embryogenesis.
Corson LB, Yamanaka Y, Lai KM, Rossant J
Development 2003 Oct 130(19):4527-37 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Daniel Constam
Evaluated 1 Sep 2003

Physical properties of Tld, Sog, Tsg and Dpp protein interactions are predicted to help create a sharp boundary in Bmp signals during dorsoventral patterning of the Drosophila embryo.
Shimmi O, O'Connor MB
Development 2003 Oct 130(19):4673-82 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Daniel Constam
Evaluated 1 Sep 2003

Nodal signaling induces the midline barrier by activating Nodal expression in the lateral plate.
Yamamoto M, Mine N, …, Meno C, Hamada H
Development 2003 May 130(9):1795-804 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Daniel Constam
Evaluated 13 Jun 2003

A novel role for a nodal-related protein; Xnr3 regulates convergent extension movements via the FGF receptor.
Yokota C, Kofron M, …, Wylie CC, Heasman J
Development 2003 May 130(10):2199-212 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Daniel Constam
Evaluated 15 Apr 2003

The BMP7/ActRII extracellular domain complex provides new insights into the cooperative nature of receptor assembly.
Greenwald J, Groppe J, …, Vale W, Choe S
Mol Cell 2003 Mar 11(3):605-17 [abstract on PubMed] [related articles] [order article]
Selected by | Daniel Constam / Yigong Shi
Evaluated 11 Apr 2003

Nodal signaling in Xenopus gastrulae is cell-autonomous and patterned by beta-catenin.
Hashimoto-Partyka MK, Yuge M, Cho KW
Dev Biol 2003 Jan 1 253(1):125-38 [abstract on PubMed] [related articles] [order article]
Selected by | Daniel Constam
Evaluated 22 Jan 2003

Nodal antagonists in the anterior visceral endoderm prevent the formation of multiple primitive streaks.
Perea-Gomez A, Vella FD, …, Behringer RR, Ang SL
Dev Cell 2002 Nov 3(5):745-56 [abstract on PubMed] [related articles] [order article]
Selected by | David Kimelman / Daniel Constam / Andrew Lumsden
Evaluated 22 Nov 2002

Site of the previous meiotic division defines cleavage orientation in the mouse embryo.
Plusa B, Grabarek JB, …, Glover DM, Zernicka-Goetz M
Nat Cell Biol 2002 Oct 4(10):811-5 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Claudio Stern / Daniel Constam
Evaluated 21 Nov 2002

Early patterning of the mouse embryo--contributions of sperm and egg.
Piotrowska K, Zernicka-Goetz M
Development 2002 Dec 129(24):5803-13 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Claudio Stern / Daniel Constam / Patrick Tam
Evaluated 21 Nov 2002

Formation of multiple hearts in mice following deletion of beta-catenin in the embryonic endoderm.
Lickert H, Kutsch S, …, Taketo MM, Kemler R
Dev Cell 2002 Aug 3(2):171-81 [abstract on PubMed] [related articles] [order article]
Selected by | Didier Stainier / Roger Patient / Daniel Constam / Patrick Tam
Evaluated 1 Oct 2002

Cell movement patterns during gastrulation in the chick are controlled by positive and negative chemotaxis mediated by FGF4 and FGF8.
Yang X, Dormann D, Münsterberg AE, Weijer CJ
Dev Cell 2002 Sep 3(3):425-37 [abstract on PubMed] [related articles] [order article]
Selected by | Rudi Winklbauer / Daniel Constam / Richard Gomer
Evaluated 1 Oct 2002

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