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Bino John
Department of Computational Biology, University of Pittsburgh School of Medicine & Cancer Institute, United States of America

Faculty Member: Genomics & Genetics > Bioinformatics [ since 25 June 2008 ]
[ Sponsorship ] [ Biography ] [ Homepage ] [ Evaluations ]
Sponsorship

Bino John sponsors free access to F1000 for Indian Institute of Technology. Supporting F1000's initiative to make itself available to scientists in all countries, including free access to developing countries (more details).

Biography

The broad objective of our research is to help cure human diseases by developing bioinformatics/computational and experimental methods to study gene functions. Recent studies link non-protein-coding RNAs to cancer and other diseases. Noncoding RNAs such as microRNAs are thought to post-transcriptionally regulate a large number of human genes. The research on non-coding RNAs is likely to provide new diagnostic and prognostic markers and eventually therapeutic targets for the treatment of human diseases. We also aim to develop methods to aid computer aided drug design efforts. Our research strategy is to apply bioinformatics/computational methods to formulate reasonable hypotheses about interesting biological problems and subsequently conduct experiments to test them. Current projects in our laboratory include but are not limited to:
1. Discovering new microRNAs
2. Identifying functions of specific disease (eg, viruses and cancer) associated microRNAs
3. Identifying novel gene regulatory networks in cancer and other diseases.
4. Developing new methods to determine protein/rna structure

Bino John, PhD, Asst. Professor
University of Pittsburgh School of Medicine & Cancer Institute
3080 Biomedical Science Tower 3
3501 Fifth Avenue
Pittsburgh, PA 15213,USA
Phone:(412) 648-8607
Email: email

Home page

http://www.johnlab.org

to email [Help]
Evaluations

Characterizing the cancer genome in lung adenocarcinoma.
Weir BA, Woo MS, …, Lander ES, Meyerson M
Nature 2007 Dec 6 450(7171):893-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Thomas Ried / Bino John
Evaluated 12 Dec 2007


miRNAs control gene expression in the single-cell alga Chlamydomonas reinhardtii.
Molnár A, Schwach F, …, Thuenemann EC, Baulcombe DC
Nature 2007 Jun 28 447(7148):1126-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Bino John
Evaluated 17 Jul 2007

An mRNA m7G cap binding-like motif within human Ago2 represses translation.
Kiriakidou M, Tan GS, …, Nelson PT, Mourelatos Z
Cell 2007 Jun 15 129(6):1141-51 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Bino John / Michael Kiebler / Michael Cole / Nektarios Tavernarakis
Evaluated 30 May 2007

A role for Piwi and piRNAs in germ cell maintenance and transposon silencing in Zebrafish.
Houwing S, Kamminga LM, …, Draper BW, Ketting RF
Cell 2007 Apr 6 129(1):69-82 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Bino John
Evaluated 16 Apr 2007

Discrete small RNA-generating loci as master regulators of transposon activity in Drosophila.
Brennecke J, Aravin AA, …, Sachidanandam R, Hannon GJ
Cell 2007 Mar 23 128(6):1089-103 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jef Boeke / Donald Rio / John Jaenike / Bino John / Michael Kiebler
Evaluated 13 Apr 2007

Large-scale sequencing reveals 21U-RNAs and additional microRNAs and endogenous siRNAs in C. elegans.
Ruby JG, Jan C, …, Ge H, Bartel DP
Cell 2006 Dec 15 127(6):1193-207 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Bino John / B. Montgomery Pettitt
Evaluated 12 Jan 2007

Can a biologist fix a radio?--Or, what I learned while studying apoptosis.
Lazebnik Y
Cancer Cell 2002 Sep 2(3):179-82 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Orion Weiner / Bino John / Yi-Kuo Yu / Winston Hide
Evaluated 1 Nov 2006

Tandem riboswitch architectures exhibit complex gene control functions.
Sudarsan N, Hammond MC, …, Roth A, Breaker RR
Science 2006-10-13 314(5797):300-4 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Bino John
Evaluated 1 Nov 2006

The 160-kilobase genome of the bacterial endosymbiont Carsonella.
Nakabachi A, Yamashita A, …, Moran NA, Hattori M
Science 2006 Oct 13 314(5797):267 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Bino John
Evaluated 25 Oct 2006

Anti-apoptotic function of a microRNA encoded by the HSV-1 latency-associated transcript.
Gupta A, Gartner JJ, …, Hatzigeorgiou AG, Fraser NW
Nature 2006 Jul 6 442(7098):82-5 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Peter Sarnow / Bino John / Michael Kiebler / Fritz Eckstein / Ulf Pettersson
Evaluated 7 Jul 2006

A common variant associated with prostate cancer in European and African populations.
Amundadottir LT, Sulem P, …, Thorsteinsdottir U, Stefansson K
Nat Genet 2006 Jun 38(6):652-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Bino John / Ulf Pettersson
Evaluated 11 May 2006

Synergistic functions of SII and p300 in productive activator-dependent transcription of chromatin templates.
Guermah M, Palhan VB, …, Chait BT, Roeder RG
Cell 2006 Apr 21 125(2):275-86 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Bino John
Evaluated 9 May 2006

Folding DNA to create nanoscale shapes and patterns.
Rothemund PW
Nature 2006 Mar 16 440(7082):297-302 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Richard Willson / Bino John / Chengde Mao / John Reif / Sabine Müller / Etienne Joly / Kenneth Zaret
Evaluated 21 Mar 2006

Zebrafish MiR-430 promotes deadenylation and clearance of maternal mRNAs.
Giraldez AJ, Mishima Y, …, Enright AJ, Schier AF
Science 2006 Apr 7 312(5770):75-9 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Bino John / Elsebet Lund / Ivor Mason / Fritz Eckstein / Roger Patient
Evaluated 20 Feb 2006

A developmental timing microRNA and its target regulate life span in C. elegans.
Boehm M, Slack F
Science 2005 Dec 23 310(5756):1954-7 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Bino John
Evaluated 3 Jan 2006

A minicircuitry comprised of microRNA-223 and transcription factors NFI-A and C/EBPalpha regulates human granulopoiesis.
Fazi F, Rosa A, …, Nervi C, Bozzoni I
Cell 2005 Dec 2 123(5):819-31 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Bino John / Andrew D. Sharrocks
Evaluated 5 Dec 2005

The widespread impact of mammalian MicroRNAs on mRNA repression and evolution.
Farh KK, Grimson A, …, Burge CB, Bartel DP
Science 2005 Dec 16 310(5755):1817-21 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Bino John / Phillip Zamore / Fritz Eckstein / Stephen Holbrook
Evaluated 2 Dec 2005

Human RISC couples microRNA biogenesis and posttranscriptional gene silencing.
Gregory RI, Chendrimada TP, Cooch N, Shiekhattar R
Cell 2005 Nov 18 123(4):631-40 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Isaac Kohane / Bino John
Evaluated 21 Nov 2005

A MicroRNA signature associated with prognosis and progression in chronic lymphocytic leukemia.
Calin GA, Ferracin M, …, Negrini M, Croce CM
N Engl J Med 2005 Oct 27 353(17):1793-801 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Bino John
Evaluated 2 Nov 2005

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