Martin Humphries sponsors free access to F1000 for POSTECH (Pohang University of Science and Technology), Pohang, Korea, South. Supporting F1000's initiative to make itself available to scientists in all countries, including free access to developing countries (more details).

Kindlin-2 (Mig-2): a co-activator of beta3 integrins. Ma YQ, Qin J, Wu C, Plow EF J Cell Biol 2008 May 5 181(3):439-46 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Martin A. Schwartz / Mark Ginsberg / Xiaoping Du / Martin Humphries Evaluated 10 Jun 2008 Directional migration of neural crest cells in vivo is regulated by Syndecan-4/Rac1 and non-canonical Wnt signaling/RhoA. Matthews HK, Marchant L, …, Parsons M, Mayor R Development 2008 Apr 9 [abstract on PubMed] [related articles] [full text] Selected by | Martin Humphries Evaluated 22 Apr 2008 Kindlin-3 is essential for integrin activation and platelet aggregation. Moser M, Nieswandt B, …, Pozgajova M, Fässler R Nat Med 2008 Mar 14(3):325-30 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Steve Watson / Martin Humphries / Sanford Shattil / Dietmar Vestweber / Xiaoping Du / Klaus Ley / Mark Ginsberg Evaluated 5 Mar 2008 KRIT-1/CCM1 is a Rap1 effector that regulates endothelial cell cell junctions. Glading A, Han J, Stockton RA, Ginsberg MH J Cell Biol 2007 Oct 22 179(2):247-54 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Martin Humphries Evaluated 3 Jan 2008 Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Wellcome Trust Case Control Consortium Nature 2007 Jun 7 447(7145):661-78 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Martin Humphries / Sue Malcolm / Bruno Stieger / David Brook Evaluated 12 Jun 2007 alpha v beta3 and alpha5beta1 integrin recycling pathways dictate downstream Rho kinase signaling to regulate persistent cell migration. White DP, Caswell PT, Norman JC J Cell Biol 2007 May 7 177(3):515-25 [abstract on PubMed] [related articles] [FREE full text] Selected by | Martin Humphries / Yoshimi Takai / Alan Rick Horwitz / Stephen Schwartz Evaluated 16 May 2007 Polymerizing actin fibers position integrins primed to probe for adhesion sites. Galbraith CG, Yamada KM, Galbraith JA Science 2007 Feb 16 315(5814):992-5 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Martin Humphries / Ed Manser Evaluated 21 Feb 2007 Differential transmission of actin motion within focal adhesions. Hu K, Ji L, …, Danuser G, Waterman-Storer CM Science 2007 Jan 5 315(5808):111-5 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Kenneth Yamada / Martin Humphries / Orion Weiner Evaluated 2 Feb 2007 Integrin-mediated adhesion regulates membrane order. Gaus K, Le Lay S, Balasubramanian N, Schwartz MA J Cell Biol 2006 Aug 28 174(5):725-34 [abstract on PubMed] [related articles] [FREE full text] Selected by | Martin Humphries Evaluated 5 Sep 2006 Merlin/NF-2 mediates contact inhibition of growth by suppressing recruitment of Rac to the plasma membrane. Okada T, Lopez-Lago M, Giancotti FG J Cell Biol 2005 Oct 24 171(2):361-71 [abstract on PubMed] [related articles] [FREE full text] Selected by | Jonathan Chernoff / Martin Humphries Evaluated 11 Jan 2006 A Rac switch regulates random versus directionally persistent cell migration. Pankov R, Endo Y, …, Matsumoto K, Yamada KM J Cell Biol 2005 Aug 29 170(5):793-802 [abstract on PubMed] [related articles] [FREE full text] Selected by | Martin Humphries Evaluated 5 Sep 2005 Microtubule-induced focal adhesion disassembly is mediated by dynamin and focal adhesion kinase. Ezratty EJ, Partridge MA, Gundersen GG Nat Cell Biol 2005 Jun 7(6):581-90 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Martin Humphries Evaluated 17 Jun 2005 Three-dimensional EM structure of the ectodomain of integrin {alpha}V{beta}3 in a complex with fibronectin. Adair BD, Xiong JP, …, Arnaout MA, Yeager M J Cell Biol 2005 Mar 28 168(7):1109-18 [abstract on PubMed] [related articles] [FREE full text] Selected by | Martin Humphries / Kenneth Yamada Evaluated 1 Apr 2005 R-Ras controls membrane protrusion and cell migration through the spatial regulation of Rac and Rho. Wozniak MA, Kwong L, …, Klemke RL, Keely PJ Mol Biol Cell 2005 Jan 16(1):84-96 [abstract on PubMed] [related articles] [FREE full text] Selected by | Martin Humphries Evaluated 4 Feb 2005 Transmembrane domain helix packing stabilizes integrin alphaIIbbeta3 in the low affinity state. Partridge AW, Liu S, …, Bowie JU, Ginsberg MH J Biol Chem 2005 Feb 25 280(8):7294-300 [abstract on PubMed] [related articles] [FREE full text] Selected by | Martin Humphries / Robert Liddington Evaluated 3 Feb 2005 Activation of endogenous Cdc42 visualized in living cells. Nalbant P, Hodgson L, …, Toutchkine A, Hahn KM Science 2004 Sep 10 305(5690):1615-9 [abstract on PubMed] [related articles] [FREE full text] Selected by | Beverly Wendland / Anna Huttenlocher / Martin Humphries / Wen-hong Li Evaluated 27 Sep 2004 Structural basis for allostery in integrins and binding to fibrinogen-mimetic therapeutics. Xiao T, Takagi J, …, Wang JH, Springer TA Nature 2004 Nov 4 432(7013):59-67 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Martin Humphries / Manfred Schliwa / Shiv Pillai / David Stokes Evaluated 27 Sep 2004 Activation of a vinculin-binding site in the talin rod involves rearrangement of a five-helix bundle. Papagrigoriou E, Gingras AR, …, Critchley DR, Emsley J EMBO J 2004 Aug 4 23(15):2942-51 [abstract on PubMed] [related articles] [FREE full text] Selected by | Martin Humphries Evaluated 28 Jul 2004 Conditional beta1-integrin gene deletion in neural crest cells causes severe developmental alterations of the peripheral nervous system. Pietri T, Eder O, …, Thiery JP, Dufour S Development 2004 Aug 131(16):3871-83 [abstract on PubMed] [related articles] [FREE full text] Selected by | Martin Humphries Evaluated 27 Jul 2004 Endorepellin causes endothelial cell disassembly of actin cytoskeleton and focal adhesions through alpha2beta1 integrin. Bix G, Fu J, …, Reed CC, Iozzo RV J Cell Biol 2004 Jul 5 166(1):97-109 [abstract on PubMed] [related articles] [FREE full text] Selected by | Richard L. Stevens / Martin Humphries Evaluated 27 Jul 2004 RNA and RNA binding proteins participate in early stages of cell spreading through spreading initiation centers. de Hoog CL, Foster LJ, Mann M Cell 2004 May 28 117(5):649-62 [abstract on PubMed] [related articles] [order article] Selected by | Peter Ekblom / Francisco Sanchez-Madrid / Martin Humphries / Michael Gold / Anna Huttenlocher Evaluated 9 Jul 2004 Increased primary tumor growth in mice null for beta3- or beta3/beta5-integrins or selectins. Taverna D, Moher H, …, Varki A, Hynes RO Proc Natl Acad Sci U S A 2004 Jan 20 101(3):763-8 [abstract on PubMed] [related articles] [FREE full text] Selected by | Peter Ekblom / Martin Humphries Evaluated 24 Mar 2004 Localized stabilization of microtubules by integrin- and FAK-facilitated Rho signaling. Palazzo AF, Eng CH, …, Marcantonio EE, Gundersen GG Science 2004 Feb 6 303(5659):836-9 [abstract on PubMed] [related articles] [FREE full text] Selected by | Orly Reiner / Kermit Carraway / Ed Manser / Martin Humphries Evaluated 18 Mar 2004 Integrins regulate Rac targeting by internalization of membrane domains. del Pozo MA, Alderson NB, …, Anderson RG, Schwartz MA Science 2004 Feb 6 303(5659):839-42 [abstract on PubMed] [related articles] [FREE full text] Selected by | Valeri Vasioukhin / Robert Parton / Kermit Carraway / Anna Huttenlocher / Martin Humphries / Charles Streuli Evaluated 18 Mar 2004 Talin binding to integrin beta tails: a final common step in integrin activation. Tadokoro S, Shattil SJ, …, Ginsberg MH, Calderwood DA Science 2003 Oct 3 302(5642):103-6 [abstract on PubMed] [related articles] [FREE full text] Selected by | Martin Humphries / Kenneth Yamada / Eric Brown / Klaus Ley Evaluated 14 Oct 2003 RAPL, a Rap1-binding molecule that mediates Rap1-induced adhesion through spatial regulation of LFA-1. Katagiri K, Maeda A, Shimonaka M, Kinashi T Nat Immunol 2003 Aug 4(8):741-8 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Michael Gold / Martin Humphries / Alfred Wittinghofer Evaluated 8 Sep 2003 Spatial restriction of alpha4 integrin phosphorylation regulates lamellipodial stability and alpha4beta1-dependent cell migration. Goldfinger LE, Han J, …, Howe AK, Ginsberg MH J Cell Biol 2003 Aug 18 162(4):731-41 [abstract on PubMed] [related articles] [FREE full text] Selected by | Martin Humphries / Timothy Springer Evaluated 8 Sep 2003 Semaphorin 7A promotes axon outgrowth through integrins and MAPKs. Pasterkamp RJ, Peschon JJ, Spriggs MK, Kolodkin AL Nature 2003 Jul 24 424(6947):398-405 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Martin Humphries / Ruediger Klein / Liqun Luo Evaluated 5 Aug 2003 Two-piconewton slip bond between fibronectin and the cytoskeleton depends on talin. Jiang G, Giannone G, …, Fukumoto E, Sheetz MP Nature 2003 Jul 17 424(6946):334-7 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Martin Humphries Evaluated 25 Jul 2003 UNC-71, a disintegrin and metalloprotease (ADAM) protein, regulates motor axon guidance and sex myoblast migration in C. elegans. Huang X, Huang P, …, Stern MJ, Jin Y Development 2003 Jul 130(14):3147-61 [abstract on PubMed] [related articles] [FREE full text] Selected by | Denise Montell / Martin Humphries Evaluated 17 Jul 2003 JNK phosphorylates paxillin and regulates cell migration. Huang C, Rajfur Z, …, Schaller MD, Jacobson K Nature 2003 Jul 10 424(6945):219-23 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Martin Humphries / Kenneth Yamada / Sheila Thomas Evaluated 17 Jul 2003 The contribution of glycoprotein VI to stable platelet adhesion and thrombus formation illustrated by targeted gene deletion. Kato K, Kanaji T, …, Ruggeri ZM, Ware J Blood 2003 Sep 1 102(5):1701-7 [abstract on PubMed] [related articles] [FREE full text] Selected by | Martin Humphries Evaluated 4 Jun 2003 Receptor tyrosine kinase Axl modulates the osteogenic differentiation of pericytes. Collett G, Wood A, …, Fridell YW, Canfield AE Circ Res 2003 May 30 92(10):1123-9 [abstract on PubMed] [related articles] [FREE full text] Selected by | Martin Humphries Evaluated 4 Jun 2003 Switch-of-function mutants based on morphology classification of Ras superfamily small GTPases. Heo WD, Meyer T Cell 2003 May 2 113(3):315-28 [abstract on PubMed] [related articles] [order article] Selected by | Henry R. Bourne / Michael Gold / David Lambright / Philippe I. Bastiaens / Martin Humphries / Channing Der Evaluated 2 Jun 2003 Activation of integrin alphaIIbbeta3 by modulation of transmembrane helix associations. Li R, Mitra N, …, DeGrado WF, Bennett JS Science 2003 May 2 300(5620):795-8 [abstract on PubMed] [related articles] [FREE full text] Selected by | Filippo Giancotti / Martin Humphries Evaluated 30 May 2003 Migfilin and Mig-2 link focal adhesions to filamin and the actin cytoskeleton and function in cell shape modulation. Tu Y, Wu S, …, Chen K, Wu C Cell 2003 Apr 4 113(1):37-47 [abstract on PubMed] [related articles] [order article] Selected by | Carol Otey / Kenneth Yamada / Martin Humphries Evaluated 30 May 2003 Pathogenic bacteria attach to human fibronectin through a tandem beta-zipper. Schwarz-Linek U, Werner JM, …, Campbell ID, Potts JR Nature 2003 May 8 423(6936):177-81 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Martin Humphries Evaluated 12 May 2003 Plasma fibronectin promotes thrombus growth and stability in injured arterioles. Ni H, Yuen PS, …, Hynes RO, Wagner DD Proc Natl Acad Sci U S A 2003 Mar 4 100(5):2415-9 [abstract on PubMed] [related articles] [FREE full text] Selected by | Martin Humphries Evaluated 14 Apr 2003 PKCepsilon is a permissive link in integrin-dependent IFN-gamma signalling that facilitates JAK phosphorylation of STAT1. Ivaska J, Bosca L, Parker PJ Nat Cell Biol 2003 Apr 5(4):363-9 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Martin Humphries / Charles Streuli Evaluated 9 Apr 2003 Integrin beta cytoplasmic domain interactions with phosphotyrosine-binding domains: a structural prototype for diversity in integrin signaling. Calderwood DA, Fujioka Y, …, Liddington RC, Ginsberg MH Proc Natl Acad Sci U S A 2003 Mar 4 100(5):2272-7 [abstract on PubMed] [related articles] [FREE full text] Selected by | Timothy Springer / Alan Rick Horwitz / Martin A. Schwartz / Martin Humphries Evaluated 9 Apr 2003 Structures of the alpha L I domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation. Shimaoka M, Xiao T, …, Wang JH, Springer TA Cell 2003 Jan 10 112(1):99-111 [abstract on PubMed] [related articles] [order article] Selected by | Martin Humphries Evaluated 18 Feb 2003 Melusin, a muscle-specific integrin beta1-interacting protein, is required to prevent cardiac failure in response to chronic pressure overload. Brancaccio M, Fratta L, …, Tarone G, Lembo G Nat Med 2003 Jan 9(1):68-75 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Martin Humphries Evaluated 17 Feb 2003 Regulation of integrin growth factor interactions in oligodendrocytes by lipid raft microdomains. Baron W, Decker L, Colognato H, ffrench-Constant C Curr Biol 2003 Jan 21 13(2):151-5 [abstract on PubMed] [related articles] [order article] Selected by | Martin Humphries Evaluated 17 Feb 2003 A novel form of integrin dysfunction involving beta1, beta2, and beta3 integrins. McDowall A, Inwald D, …, Klein N, Hogg N J Clin Invest 2003 Jan 111(1):51-60 [abstract on PubMed] [related articles] [FREE full text] Selected by | John Couchman / Dietmar Vestweber / Martin Humphries Evaluated 17 Feb 2003 Three-dimensional model of the human platelet integrin alpha IIbbeta 3 based on electron cryomicroscopy and x-ray crystallography. Adair BD, Yeager M Proc Natl Acad Sci U S A 2002 Oct 29 99(22):14059-64 [abstract on PubMed] [related articles] [FREE full text] Selected by | Martin Humphries Evaluated 31 Oct 2002 Global conformational rearrangements in integrin extracellular domains in outside-in and inside-out signaling. Takagi J, Petre BM, Walz T, Springer TA Cell 2002 Sep 6 110(5):599-11 [abstract on PubMed] [related articles] [order article] Selected by | Martin Humphries / Robert Liddington / Fiona Watt / David Stokes Evaluated 19 Sep 2002 A structural mechanism of integrin alpha(IIb)beta(3) "inside-out" activation as regulated by its cytoplasmic face. Vinogradova O, Velyvis A, …, Plow E, Qin J Cell 2002 Sep 6 110(5):587-97 [abstract on PubMed] [related articles] [order article] Selected by | Martin Humphries / Robert Liddington / Fiona Watt Evaluated 19 Sep 2002 Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck. Eden S, Rohatgi R, …, Mann M, Kirschner MW Nature 2002 Aug 15 418(6899):790-3 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Martin Humphries / Sally Zigmond Evaluated 10 Sep 2002 PIP(2)-PDZ domain binding controls the association of syntenin with the plasma membrane. Zimmermann P, Meerschaert K, …, David G, Gettemans J Mol Cell 2002 Jun 9(6):1215-25 [abstract on PubMed] [related articles] [order article] Selected by | John Couchman / Andreas Wodarz / Craig Montell / Martin Humphries Evaluated 3 Sep 2002 Agonist-specific structural rearrangements of integrin alpha IIbbeta 3. Confirmation of the bent conformation in platelets at rest and after activation. Calzada MJ, Alvarez MV, Gonzalez-Rodriguez J J Biol Chem 2002 Oct 18 277(42):39899-908 [abstract on PubMed] [related articles] [FREE full text] Selected by | Martin Humphries Evaluated 23 Aug 2002 The phosphotyrosine binding-like domain of talin activates integrins. Calderwood DA, Yan B, …, Liddington RC, Ginsberg MH J Biol Chem 2002 Jun 14 277(24):21749-58 [abstract on PubMed] [related articles] [FREE full text] Selected by | Martin Humphries Evaluated 23 Aug 2002 Tumor regression by targeted gene delivery to the neovasculature. Hood JD, Bednarski M, …, Xiang R, Cheresh DA Science 2002 Jun 28 296(5577):2404-7 [abstract on PubMed] [related articles] [FREE full text] Selected by | Ulf Pettersson / Charles Streuli / Kermit Carraway / Chandra Kumar / Martin Humphries Evaluated 23 Aug 2002 Novel vascular endothelial growth factor binding domains of fibronectin enhance vascular endothelial growth factor biological activity. Wijelath ES, Murray J, …, Rafii S, Sobel M Circ Res 2002 Jul 12 91(1):25-31 [abstract on PubMed] [related articles] [FREE full text] Selected by | Martin Humphries Evaluated 23 Aug 2002 Crystal structure of the extracellular segment of integrin alpha Vbeta3 in complex with an Arg-Gly-Asp ligand. Xiong JP, Stehle T, …, Goodman SL, Arnaout MA Science 2002 Apr 5 296(5565):151-5 [abstract on PubMed] [related articles] [FREE full text] Selected by | John Couchman / Robert Liddington / Vance Lemmon / Alfred Wittinghofer / Martin Humphries Evaluated 29 May 2002 Does the integrin alphaA domain act as a ligand for its betaA domain? Alonso JL, Essafi M, …, Stehle T, Arnaout MA Curr Biol 2002 May 14 12(10):R340-2 [abstract on PubMed] [related articles] [order article] Selected by | Martin Humphries Evaluated 27 May 2002 Integrin clustering induces kinectin accumulation. Tran H, Pankov R, …, Burgess WH, Yamada KM J Cell Sci 2002 May 15 115(Pt 10):2031-40 [abstract on PubMed] [related articles] [FREE full text] Selected by | Martin Humphries Evaluated 30 Apr 2002 Integrins regulate GTP-Rac localized effector interactions through dissociation of Rho-GDI. Del Pozo MA, Kiosses WB, …, Hahn KM, Schwartz MA Nat Cell Biol 2002 Mar 4(3):232-9 [abstract on PubMed] [related articles] [full text] [order article] Selected by | John Couchman / Kristiina Vuori / Denise Montell / Martin Humphries / Charles Streuli Evaluated 24 Apr 2002 Cysteine-rich module structure reveals a fulcrum for integrin rearrangement upon activation. Beglova N, Blacklow SC, Takagi J, Springer TA Nat Struct Biol 2002 Apr 9(4):282-7 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Kristina Downing / Martin Humphries / Robert Liddington / H Jane Dyson Evaluated 16 Apr 2002 Increased filamin binding to beta-integrin cytoplasmic domains inhibits cell migration. Calderwood DA, Huttenlocher A, …, Schwartz MA, Ginsberg MH Nat Cell Biol 2001 Dec 3(12):1060-8 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Martin Humphries / Jean Schwarzbauer / Juliet Lee Evaluated 15 Jan 2002 RhoA inactivation by p190RhoGAP regulates cell spreading and migration by promoting membrane protrusion and polarity. Arthur WT, Burridge K Mol Biol Cell 2001 Sep 12(9):2711-20 [abstract on PubMed] [related articles] [FREE full text] Selected by | Bruce Stevenson / Martin Humphries Evaluated 19 Nov 2001 Taking cell-matrix adhesions to the third dimension. Cukierman E, Pankov R, Stevens DR, Yamada KM Science 2001 Nov 23 294(5547):1708-12 [abstract on PubMed] [related articles] [FREE full text] Selected by | Martin Humphries / Anna Huttenlocher / Dafna Bar-Sagi / Charles Streuli Evaluated 5 Dec 2001 Oligomerization of the integrin alphaIIbbeta3: roles of the transmembrane and cytoplasmic domains. Li R, Babu CR, …, Bennett JS, DeGrado WF Proc Natl Acad Sci U S A 2001 Oct 23 98(22):12462-7 [abstract on PubMed] [related articles] [FREE full text] Selected by | Martin Humphries Evaluated 4 Dec 2001 Crystal structure of the extracellular segment of integrin alpha Vbeta3. Xiong JP, Stehle T, …, Goodman SL, Arnaout MA Science 2001 Oct 12 294(5541):339-45 [abstract on PubMed] [related articles] [FREE full text] Selected by | Martin Humphries / Nick Brown / Wolfgang Guba Evaluated 25 Oct 2001

^Top  Back to Faculty Members