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Dale Umetsu
Pediatrics, Children's Hospital Boston, Harvard Medical School, United States of America

Faculty Member: Immunology > Allergy & Hypersensitivity [ since 21 January 2002 ]
[ Biography ] [ Homepage ] [ Evaluations ]
Biography

Dale T. Umetsu, MD, PhD
Professor of Pediatrics
Stanford University

Home page

http://www.stanford.edu/~umetsu/

to email [Help]
Evaluations

Association between paracetamol use in infancy and childhood, and risk of asthma, rhinoconjunctivitis, and eczema in children aged 6-7 years: analysis from Phase Three of the ISAAC programme.
Beasley R, Clayton T, …, Stewart A, ISAAC Phase Three Study Group
Lancet 2008 Sep 20 372(9643):1039-48 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Dale Umetsu
Evaluated 3 Oct 2008


The transcription factor PLZF directs the effector program of the NKT cell lineage.
Savage AK, Constantinides MG, …, Lantz O, Bendelac A
Immunity 2008 Sep 29(3):391-403 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Dale Umetsu
Evaluated 23 Sep 2008

Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants.
Eisenbarth SC, Colegio OR, …, Sutterwala FS, Flavell RA
Nature 2008 Jun 19 453(7198):1122-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Drusilla Burns / David Chaplin / Dale Umetsu / Shizuo Akira
Evaluated 28 Jul 2008


Persistent activation of an innate immune response translates respiratory viral infection into chronic lung disease.
Kim EY, Battaile JT, …, Peltz G, Holtzman MJ
Nat Med 2008 Jun 14(6):633-40 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Dale Umetsu / Achsah Keegan
Evaluated 12 Jun 2008


Breast milk-mediated transfer of an antigen induces tolerance and protection from allergic asthma.
Verhasselt V, Milcent V, …, Glaichenhaus N, Julia V
Nat Med 2008 Feb 14(2):170-5 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | William Seaman / Dale Umetsu
Evaluated 13 Mar 2008


CD4+CD25+Foxp3+ regulatory T cells induce cytokine deprivation-mediated apoptosis of effector CD4+ T cells.
Pandiyan P, Zheng L, …, Reed J, Lenardo MJ
Nat Immunol 2007 Dec 8(12):1353-62 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Thomas Hunig / Kendall Smith / Deborah Fowell / Dale Umetsu
Evaluated 15 Jan 2008

Identification of Tim4 as a phosphatidylserine receptor.
Miyanishi M, Tada K, …, Kitamura T, Nagata S
Nature 2007 Nov 15 450(7168):435-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Dale Umetsu / Shai Shaham / Christoph Borner / Jean Pieters
Evaluated 9 Nov 2007

Development, cytokine profile and function of human interleukin 17-producing helper T cells.
Wilson NJ, Boniface K, …, Bowman EP, de Waal Malefyt R
Nat Immunol 2007 Sep 8(9):950-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Dale Umetsu / Steve Ward
Evaluated 19 Sep 2007

Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells.
Acosta-Rodriguez EV, Rivino L, …, Sallusto F, Napolitani G
Nat Immunol 2007 Jun 8(6):639-46 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Torben Lund / Steve Ward / Dale Umetsu / Toshinori Nakayama / Paula Sundstrom
Evaluated 13 Jul 2007


Asymmetric T lymphocyte division in the initiation of adaptive immune responses.
Chang JT, Palanivel VR, …, Weninger W, Reiner SL
Science 2007 Mar 23 315(5819):1687-91 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | George Yap / Toshinori Nakayama / Richard Locksley / Etienne Joly / Torben Lund / Christian Engwerda / Stephen Doxsey / Clifford Harding / Leo Lefrancois / Shiv Pillai / Rong Li / Dale Umetsu / Michael Dustin / Francisco Sanchez-Madrid
Evaluated 10 May 2007


Thymic stromal lymphopoietin is released by human epithelial cells in response to microbes, trauma, or inflammation and potently activates mast cells.
Allakhverdi Z, Comeau MR, …, Sarfati M, Delespesse G
J Exp Med 2007 Feb 19 204(2):253-8 [abstract on PubMed] [related articles] [FREE full text]
Selected by | P'ng Loke / Marc Rothenberg / Dale Umetsu
Evaluated 11 Apr 2007

The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells.
Ivanov II, McKenzie BS, …, Cua DJ, Littman DR
Cell 2006 Sep 22 126(6):1121-33 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Caetano Reis e Sousa / Christopher A. Hunter / Casey Weaver / Richard Williams / Dale Umetsu / Klaus Ley / Mercedes Rincon / Rachel Caspi / Fraydoon Rastinejad / Astar Winoto
Evaluated 2 Nov 2006


Natural killer T cells recognize diacylglycerol antigens from pathogenic bacteria.
Kinjo Y, Tupin E, …, Wong CH, Kronenberg M
Nat Immunol 2006 Sep 7(9):978-86 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Dale Umetsu / David Branch Moody
Evaluated 31 Aug 2006

Type 2 immunity is controlled by IL-4/IL-13 expression in hematopoietic non-eosinophil cells of the innate immune system.
Voehringer D, Reese TA, …, Shinkai K, Locksley RM
J Exp Med 2006 Jun 12 203(6):1435-46 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Dale Umetsu
Evaluated 29 Aug 2006

TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells.
Veldhoen M, Hocking RJ, …, Locksley RM, Stockinger B
Immunity 2006 Feb 24(2):179-89 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Christopher A. Hunter / Rachel Caspi / Klaus Ley / Dale Umetsu
Evaluated 7 Apr 2006

Regulation of lung injury and repair by Toll-like receptors and hyaluronan.
Jiang D, Liang J, …, Medzhitov R, Noble PW
Nat Med 2005 Nov 11(11):1173-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Lora Hooper / Giorgio Berton / Dale Umetsu
Evaluated 16 Dec 2005

Hassall's corpuscles instruct dendritic cells to induce CD4+CD25+ regulatory T cells in human thymus.
Watanabe N, Wang YH, …, Cao W, Liu YJ
Nature 2005 Aug 25 436(7054):1181-5 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Gerald Nepom / Chen Dong / Steve Ward / Dale Umetsu / William A Muller / Paul Gleeson / Elizabeth Mellins
Evaluated 9 Sep 2005


A chimeric human-cat fusion protein blocks cat-induced allergy.
Zhu D, Kepley CL, …, Yamada T, Saxon A
Nat Med 2005 Apr 11(4):446-9 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Marsha Wills-Karp / Dale Umetsu
Evaluated 2 Jun 2005

Anti-interleukin-12 antibody for active Crohn's disease.
Mannon PJ, Fuss IJ, …, Strober W, Anti-IL-12 Crohn's Disease Study Group
N Engl J Med 2004 Nov 11 351(20):2069-79 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Dale Umetsu
Evaluated 23 Nov 2004

T cell-specific inactivation of the interleukin 10 gene in mice results in enhanced T cell responses but normal innate responses to lipopolysaccharide or skin irritation.
Roers A, Siewe L, …, Rajewsky K, Müller W
J Exp Med 2004 Nov 15 200(10):1289-97 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Dale Umetsu / Christopher A. Hunter
Evaluated 17 Nov 2004

Bone marrow plasmacytoid dendritic cells can differentiate into myeloid dendritic cells upon virus infection.
Zuniga EI, McGavern DB, …, Teng C, Oldstone MB
Nat Immunol 2004 Dec 5(12):1227-34 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Dale Umetsu / David Underhill / Esther Sternberg
Evaluated 17 Nov 2004

Defective suppressor function of human CD4+ CD25+ regulatory T cells in autoimmune polyglandular syndrome type II.
Kriegel MA, Lohmann T, …, Kalden JR, Lorenz HM
J Exp Med 2004 May 3 199(9):1285-91 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Dale Umetsu / Torben Lund
Evaluated 11 May 2004

Antigen-dependent proliferation of CD4+ CD25+ regulatory T cells in vivo.
Walker LS, Chodos A, …, Dooms H, Abbas AK
J Exp Med 2003 Jul 21 198(2):249-58 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Dale Umetsu
Evaluated 11 Aug 2003

Control of regulatory T cell development by the transcription factor Foxp3.
Hori S, Nomura T, Sakaguchi S
Science 2003 Feb 14 299(5609):1057-61 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Kenneth Tung / Casey Weaver / Dale Umetsu / Christopher Karp
Evaluated 27 Feb 2003

Oxazolone colitis, a Th2 colitis model resembling ulcerative colitis, is mediated by IL-13-producing NK-T cells.
Heller F, Fuss IJ, …, Blumberg RS, Strober W
Immunity 2002 Nov 17(5):629-38 [abstract on PubMed] [related articles] [order article]
Selected by | Steve Ward / Dale Umetsu
Evaluated 19 Dec 2002

Allergen-specific CD8(+) T cells and atopic disease.
Seneviratne SL, Jones L, …, McMichael AJ, Ogg GS
J Clin Invest 2002 Nov 110(9):1283-91 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Dale Umetsu
Evaluated 19 Dec 2002

Exposure to cat allergen, maternal history of asthma, and wheezing in first 5 years of life.
Celedón JC, Litonjua AA, …, Weiss ST, Gold DR
Lancet 2002 Sep 7 360(9335):781-2 [abstract on PubMed] [related articles] [order article]
Selected by | Dale Umetsu
Evaluated 8 Oct 2002

Exposure to dogs and cats in the first year of life and risk of allergic sensitization at 6 to 7 years of age.
Ownby DR, Johnson CC, Peterson EL
JAMA 2002 Aug 28 288(8):963-72 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Dale Umetsu
Evaluated 16 Sep 2002

Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness.
Van Eerdewegh P, Little RD, …, Holgate ST, Keith TP
Nature 2002 Jul 25 418(6896):426-30 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Dale Umetsu / Peter Openshaw
Evaluated 27 Aug 2002

Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP.
Soumelis V, Reche PA, …, Kastelein RA, Liu YJ
Nat Immunol 2002 Jul 3(7):673-80 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Dale Umetsu
Evaluated 4 Jul 2002

Microarray profile of differentially expressed genes in a monkey model of allergic asthma.
Zou J, Young S, …, Egan R, Umland S
Genome Biol 2002 3(5):research0020 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Dale Umetsu
Evaluated 17 Jun 2002

Synergism between allergens and viruses and risk of hospital admission with asthma: case-control study.
Green RM, Custovic A, …, Johnston SL, Woodcock A
BMJ 2002 Mar 30 324(7340):763 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Dale Umetsu
Evaluated 19 Apr 2002

Efficacy of omalizumab, an anti-immunoglobulin E antibody, in patients with allergic asthma at high risk of serious asthma-related morbidity and mortality.
Holgate S, Bousquet J, …, Liu J, Castellsague J
Curr Med Res Opin 2001 17(4):233-40 [abstract on PubMed] [related articles] [order article]
Selected by | Dale Umetsu
Evaluated 18 Apr 2002

Decreased allergic lung inflammatory cell egression and increased susceptibility to asphyxiation in MMP2-deficiency.
Corry DB, Rishi K, …, Werb Z, Kheradmand F
Nat Immunol 2002 Apr 3(4):347-53 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Dale Umetsu
Evaluated 8 Apr 2002

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