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 | Dafna Bar-Sagi
Department of Biochemistry, New York University School of Medicine, New York, United States of America | | | Faculty Member: Structural Biology > Cell Signalling & Trafficking Structures [ since 11 July 2001 ] |
| | [ Biography ] [ Homepage ] [ Evaluations ] | Biography
Research interests:
Role of Ras protein in cell proliferation and oncogenic transformation.
We are interested in signal transduction pathways involved in growth control. Our research focuses on pathways involving Ras proteins. Ras proteins are small guanine-nucleotide binding proteins that reside on the inner surface of the plasma membrane. Their critical role in mediating signals that control cell growth is indicated by the fact that mutationally activated (oncogenic) forms of ras genes have been identified in many types of human tumors. Our current work is concerned with the control mechanisms that normally regulate the biological activity of Ras proteins and the perturbation of this regulation during oncogenic transformation. We are specifically examining the mechanisms whereby cell surface receptors control the activation of Ras proteins. In addition, we are searching for cellular targets that mediate the effects of Ras proteins on cell proliferation and oncogenic transformation.
| Home page
http://www.umc.sunysb.edu/microbiology/barsagi.html |
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