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Jonathan Hodgkin
Department of Biochemistry, University of Oxford, Oxford, United Kingdom

Faculty Member: Developmental Biology > Developmental Molecular Mechanisms [ since 26 July 2001 ]
[ Sponsorship ] [ Homepage ] [ Evaluations ]
Sponsorship

Jonathan Hodgkin sponsors free access to F1000 for Worldfish Center, Penang, Malaysia. Supporting F1000's initiative to make itself available to scientists in all countries, including free access to developing countries (more details).

Home page

http://www.bioch.ox.ac.uk/aspsite/index.asp?pageid=73&Group_ID=53

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Evaluations

Molecular basis of the copulatory plug polymorphism in Caenorhabditis elegans.
Palopoli MF, Rockman MV, …, Laurita J, Kruglyak L
Nature 2008 Jul 16 [abstract on PubMed] [related articles] [full text]
Selected by | David Fitch / Jonathan Hodgkin
Evaluated 31 Jul 2008

Genome Integrity Is Regulated by the Caenorhabditis elegans Rad51D Homolog rfs-1.
Yanowitz JL
Genetics 2008 May 179(1):249-62 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jonathan Hodgkin
Evaluated 20 Jun 2008

Leucobacter chromiireducens subsp. solipictus Exerts Virulence on Caenorhabditis elegans, Characterization of a Novel Host-Pathogen Interaction.
Muir RE, Tan MW
Appl Environ Microbiol 2008 May 16 [abstract on PubMed] [related articles] [full text]
Selected by | Jonathan Hodgkin
Evaluated 11 Jun 2008

Patterns of molecular evolution in Caenorhabditis preclude ancient origins of selfing.
Cutter AD, Wasmuth JD, Washington NL
Genetics 2008 178:2093-104 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jonathan Hodgkin
Evaluated 2 May 2008

Haem homeostasis is regulated by the conserved and concerted functions of HRG-1 proteins.
Rajagopal A, Rao AU, …, Krause M, Hamza I
Nature 2008 Apr 16 [abstract on PubMed] [related articles] [full text]
Selected by | Ruma Banerjee / Jonathan Hodgkin
Evaluated 22 Apr 2008

GFP Reconstitution Across Synaptic Partners (GRASP) defines cell contacts and synapses in living nervous systems.
Feinberg EH, Vanhoven MK, …, Shen K, Bargmann CI
Neuron 2008 Feb 7 57(3):353-63 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jonathan Hodgkin / Venkatesh Murthy
Evaluated 12 Feb 2008

The C. elegans protein CEH-30 protects male-specific neurons from apoptosis independently of the Bcl-2 homolog CED-9.
Schwartz HT, Horvitz HR
Genes Dev 2007 Dec 1 21(23):3181-94 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jonathan Hodgkin / Christoph Borner
Evaluated 21 Dec 2007

Cortical granule exocytosis in C. elegans is regulated by cell cycle components including separase.
Bembenek JN, Richie CT, …, Golden A, White JG
Development 2007 Nov 134(21):3837-48 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Michel Labouesse / Jonathan Hodgkin
Evaluated 8 Nov 2007

The slit receptor EVA-1 coactivates a SAX-3/Robo mediated guidance signal in C. elegans.
Fujisawa K, Wrana JL, Culotti JG
Science 2007 Sep 28 317(5846):1934-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jonathan Hodgkin / Robert S Krauss / David Sherwood / Paul Garrity / Oliver Hobert
Evaluated 10 Oct 2007

Control of C. elegans hermaphrodite gonad size and shape by vab-3/Pax6-mediated regulation of integrin receptors.
Meighan CM, Schwarzbauer JE
Genes Dev 2007 Jul 1 21(13):1615-20 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jonathan Hodgkin
Evaluated 5 Sep 2007

Comparison of C. elegans and C. briggsae Genome Sequences Reveals Extensive Conservation of Chromosome Organization and Synteny.
Hillier LW, Miller RD, …, Koboldt DC, Waterston RH
PLoS Biol 2007 Jul 3 5(7):e167 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Jonathan Hodgkin
Evaluated 18 Jul 2007

Functional redundancy of worm spliceosomal proteins U1A and U2B''.
Saldi T, Wilusz C, MacMorris M, Blumenthal T
Proc Natl Acad Sci U S A 2007 Jun 5 104(23):9753-7 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Jonathan Hodgkin
Evaluated 5 Jun 2007

Efficient high-resolution deletion discovery in Caenorhabditis elegans by array comparative genomic hybridization.
Maydan JS, Flibotte S, …, Thomas JH, Moerman DG
Genome Res 2007 Mar 17(3):337-47 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Jonathan Hodgkin
Evaluated 5 Apr 2007

Timing of the onset of a developmental cell death is controlled by transcriptional induction of the C. elegans ced-3 caspase-encoding gene.
Maurer CW, Chiorazzi M, Shaham S
Development 2007 Apr 134(7):1357-68 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Jonathan Hodgkin
Evaluated 12 Mar 2007

Targeted cell killing by reconstituted caspases.
Chelur DS, Chalfie M
Proc Natl Acad Sci U S A 2007 Feb 13 104(7):2283-8 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Jonathan Hodgkin
Evaluated 14 Feb 2007

A family of zinc-finger proteins is required for chromosome-specific pairing and synapsis during meiosis in C. elegans.
Phillips CM, Dernburg AF
Dev Cell 2006 Dec 11(6):817-29 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jonathan Hodgkin / Robert K Herman
Evaluated 12 Dec 2006

The C. elegans sex-determining GLI protein TRA-1A is regulated by sex-specific proteolysis.
Schvarzstein M, Spence AM
Dev Cell 2006 Nov 11(5):733-40 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jonathan Hodgkin / Barbara Conradt
Evaluated 17 Nov 2006

The C. elegans developmental fusogen EFF-1 mediates homotypic fusion in heterologous cells and in vivo.
Podbilewicz B, Leikina E, …, Shemer G, Chernomordik LV
Dev Cell 2006 Oct 11(4):471-81 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jonathan Hodgkin / Robert K Herman / Michel Labouesse
Evaluated 11 Oct 2006

The claudin superfamily protein nsy-4 biases lateral signaling to generate left-right asymmetry in C. elegans olfactory neurons.
Vanhoven MK, Bauer Huang SL, Albin SD, Bargmann CI
Neuron 2006 Aug 3 51(3):291-302 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jonathan Hodgkin / Stephen Wilson
Evaluated 8 Aug 2006

The V0-ATPase mediates apical secretion of exosomes containing Hedgehog-related proteins in Caenorhabditis elegans.
Liégeois S, Benedetto A, …, Schwab Y, Labouesse M
J Cell Biol 2006 Jun 19 173(6):949-61 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Jonathan Hodgkin / Susan Mango
Evaluated 30 Jun 2006

Uncoupling the pleiotropic phenotypes of clk-1 with tRNA missense suppressors in Caenorhabditis elegans.
Branicky R, Nguyen PA, Hekimi S
Mol Cell Biol 2006 May 26(10):3976-85 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Jonathan Hodgkin
Evaluated 17 May 2006

Germ-line induction of the Caenorhabditis elegans vulva.
Thompson BE, Lamont LB, Kimble J
Proc Natl Acad Sci U S A 2006 Jan 17 103(3):620-5 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Jonathan Hodgkin
Evaluated 26 Jan 2006

The egg surface LDL receptor repeat-containing proteins EGG-1 and EGG-2 are required for fertilization in Caenorhabditis elegans.
Kadandale P, Stewart-Michaelis A, …, Grant BD, Singson A
Curr Biol 2005 Dec 20 15(24):2222-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jonathan Hodgkin / Jane Hubbard / Benjamin Podbilewicz
Evaluated 12 Jan 2006

SMEDWI-2 is a PIWI-like protein that regulates planarian stem cells.
Reddien PW, Oviedo NJ, …, Jenkin JC, Sánchez Alvarado A
Science 2005 Nov 25 310(5752):1327-30 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Jonathan Hodgkin
Evaluated 7 Dec 2005

Somatic control of germline sexual development is mediated by the JAK/STAT pathway.
Wawersik M, Milutinovich A, …, Williams B, Van Doren M
Nature 2005 Jul 28 436(7050):563-7 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Jonathan Hodgkin / Manfred Frasch / Marta Llimargas
Evaluated 2 Aug 2005

High genetic diversity in the chemoreceptor superfamily of Caenorhabditis elegans.
Stewart MK, Clark NL, …, Galloway EM, Thomas JH
Genetics 2005 Apr 169(4):1985-96 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Jonathan Hodgkin
Evaluated 5 Jul 2005

Multigene analyses of bilaterian animals corroborate the monophyly of Ecdysozoa, Lophotrochozoa, and Protostomia.
Philippe H, Lartillot N, Brinkmann H
Mol Biol Evol 2005 May 22(5):1246-53 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Jonathan Hodgkin
Evaluated 20 May 2005

Two pathways converge at CED-10 to mediate actin rearrangement and corpse removal in C. elegans.
Kinchen JM, Cabello J, …, Schnabel R, Hengartner MO
Nature 2005 Mar 3 434(7029):93-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jonathan Hodgkin / Barbara Conradt / Richard Lang / Michel Labouesse
Evaluated 22 Mar 2005

Chemical structure and biological activity of the Caenorhabditis elegans dauer-inducing pheromone.
Jeong PY, Jung M, …, Kim K, Paik YK
Nature 2005 Feb 3 433(7025):541-5 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jonathan Hodgkin / Linda Huang
Evaluated 9 Feb 2005

A Toll-interleukin 1 repeat protein at the synapse specifies asymmetric odorant receptor expression via ASK1 MAPKKK signaling.
Chuang CF, Bargmann CI
Genes Dev 2005 Jan 15 19(2):270-81 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Jonathan Hodgkin
Evaluated 10 Jan 2005

A transcriptomic analysis of the phylum Nematoda.
Parkinson J, Mitreva M, …, McCarter JP, Blaxter ML
Nat Genet 2004 Dec 36(12):1259-67 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jonathan Hodgkin / Thomas Nutman
Evaluated 30 Nov 2004

Crystal structure of Caenorhabditis elegans HER-1 and characterization of the interaction between HER-1 and TRA-2A.
Hamaoka BY, Dann CE, Geisbrecht BV, Leahy DJ
Proc Natl Acad Sci U S A 2004 Aug 10 101(32):11673-8 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Jonathan Hodgkin
Evaluated 10 Aug 2004

Natural variation in the npr-1 gene modifies ethanol responses of wild strains of C. elegans.
Davies AG, Bettinger JC, …, Judy ME, McIntire SL
Neuron 2004 Jun 10 42(5):731-43 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jonathan Hodgkin
Evaluated 1 Jul 2004

Caenorhabditis phylogeny predicts convergence of hermaphroditism and extensive intron loss.
Kiontke K, Gavin NP, …, Piano F, Fitch DH
Proc Natl Acad Sci U S A 2004 Jun 15 101(24):9003-8 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Jonathan Hodgkin
Evaluated 24 Jun 2004

RNase-sensitive DNA modification(s) initiates S. pombe mating-type switching.
Vengrova S, Dalgaard JZ
Genes Dev 2004 Apr 1 18(7):794-804 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Jonathan Hodgkin
Evaluated 17 May 2004

TLR-independent control of innate immunity in Caenorhabditis elegans by the TIR domain adaptor protein TIR-1, an ortholog of human SARM.
Couillault C, Pujol N, …, Kohara Y, Ewbank JJ
Nat Immunol 2004 May 5(5):488-94 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jonathan Hodgkin
Evaluated 17 May 2004

Homologous gene targeting in Caenorhabditis elegans by biolistic transformation.
Berezikov E, Bargmann CI, Plasterk RH
Nucleic Acids Res 2004 32(4):e40 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Jonathan Hodgkin / Robert K Herman
Evaluated 3 Mar 2004

The C. elegans microRNA let-7 binds to imperfect let-7 complementary sites from the lin-41 3'UTR.
Vella MC, Choi EY, …, Reinert K, Slack FJ
Genes Dev 2004 Jan 15 18(2):132-7 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Jonathan Hodgkin
Evaluated 3 Feb 2004

Long chain polyunsaturated fatty acids are required for efficient neurotransmission in C. elegans.
Lesa GM, Palfreyman M, …, Jorgensen EM, Schiavo G
J Cell Sci 2003 Dec 15 116(Pt 24):4965-75 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Jonathan Hodgkin
Evaluated 21 Jan 2004

Testis determination requires insulin receptor family function in mice.
Nef S, Verma-Kurvari S, …, Accili D, Parada LF
Nature 2003 Nov 20 426(6964):291-5 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jonathan Hodgkin
Evaluated 8 Dec 2003

The genome sequence of Caenorhabditis briggsae: a platform for comparative genomics.
Stein LD, Bao Z, …, Durbin R, Waterston RH
PLoS Biol 2003 Nov 1(2):E45 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Jonathan Hodgkin / Charles Opperman
Evaluated 27 Nov 2003

The gene csd is the primary signal for sexual development in the honeybee and encodes an SR-type protein.
Beye M, Hasselmann M, …, Page RE, Omholt SW
Cell 2003 Aug 22 114(4):419-29 [abstract on PubMed] [related articles] [order article]
Selected by | Jonathan Hodgkin
Evaluated 26 Sep 2003

SKN-1 links C. elegans mesendodermal specification to a conserved oxidative stress response.
An JH, Blackwell TK
Genes Dev 2003 Aug 1 17(15):1882-93 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Jonathan Hodgkin / Susan Mango
Evaluated 3 Sep 2003

A defect in a novel ADAMTS family member is the cause of the belted white-spotting mutation.
Rao C, Foernzler D, …, Pavan WJ, Beier DR
Development 2003 Oct 130(19):4665-72 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Jonathan Hodgkin
Evaluated 1 Sep 2003

Exclusion of germ plasm proteins from somatic lineages by cullin-dependent degradation.
DeRenzo C, Reese KJ, Seydoux G
Nature 2003 Aug 7 424(6949):685-9 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Jonathan Hodgkin / Jane Hubbard / Zhen-Qiang Pan
Evaluated 11 Aug 2003

Abundant gene conversion between arms of palindromes in human and ape Y chromosomes.
Rozen S, Skaletsky H, …, Wilson RK, Page DC
Nature 2003 Jun 19 423(6942):873-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jonathan Hodgkin / Ulf Pettersson
Evaluated 27 Jun 2003

Long-lived C. elegans daf-2 mutants are resistant to bacterial pathogens.
Garsin DA, Villanueva JM, …, Ruvkun G, Ausubel FM
Science 2003 Jun 20 300(5627):1921 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Jonathan Hodgkin / Pamela Larsen
Evaluated 27 Jun 2003

MicroRNAs and other tiny endogenous RNAs in C. elegans.
Ambros V, Lee RC, …, Williams PT, Jewell D
Curr Biol 2003 May 13 13(10):807-18 [abstract on PubMed] [related articles] [order article]
Selected by | Jonathan Hodgkin / Marjori Matzke
Evaluated 21 May 2003

XOL-1, primary determinant of sexual fate in C. elegans, is a GHMP kinase family member and a structural prototype for a class of developmental regulators.
Luz JG, Hassig CA, …, Meyer BJ, Wilson IA
Genes Dev 2003 Apr 15 17(8):977-90 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Jonathan Hodgkin
Evaluated 21 May 2003

Vertebrate microRNA genes.
Lim LP, Glasner ME, …, Burge CB, Bartel DP
Science 2003 Mar 7 299(5612):1540 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Marjori Matzke / Jonathan Hodgkin
Evaluated 25 Mar 2003

Glutamine/proline-rich PQE-1 proteins protect Caenorhabditis elegans neurons from huntingtin polyglutamine neurotoxicity.
Faber PW, Voisine C, …, Bates EA, Hart AC
Proc Natl Acad Sci U S A 2002 Dec 24 99(26):17131-6 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Jonathan Hodgkin
Evaluated 3 Mar 2003

Systematic functional analysis of the Caenorhabditis elegans genome using RNAi.
Kamath RS, Fraser AG, …, Zipperlen P, Ahringer J
Nature 2003 Jan 16 421(6920):231-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Sally Leevers / Jonathan Hodgkin / Yasushi Okazaki / William Kaelin / Eaton E. Lattman
Evaluated 22 Jan 2003

Integrating interactome, phenome, and transcriptome mapping data for the C. elegans germline.
Walhout AJ, Reboul J, …, Piano F, Vidal M
Curr Biol 2002 Nov 19 12(22):1952-8 [abstract on PubMed] [related articles] [order article]
Selected by | Jonathan Hodgkin
Evaluated 21 Jan 2003

The Drosophila takeout gene is regulated by the somatic sex-determination pathway and affects male courtship behavior.
Dauwalder B, Tsujimoto S, Moss J, Mattox W
Genes Dev 2002 Nov 15 16(22):2879-92 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Jonathan Hodgkin
Evaluated 8 Jan 2003

Mechanisms of AIF-mediated apoptotic DNA degradation in Caenorhabditis elegans.
Wang X, Yang C, …, Shi Y, Xue D
Science 2002 Nov 22 298(5598):1587-92 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Jonathan Hodgkin / Christoph Borner / Kristin White / Susan Ackerman
Evaluated 3 Dec 2002

Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans.
Herndon LA, Schmeissner PJ, …, Hall DH, Driscoll M
Nature 2002 Oct 24 419(6909):808-14 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jonathan Hodgkin / Mark Fortini
Evaluated 1 Nov 2002

Synapsis-dependent and -independent mechanisms stabilize homolog pairing during meiotic prophase in C. elegans.
MacQueen AJ, Colaiácovo MP, McDonald K, Villeneuve AM
Genes Dev 2002 Sep 15 16(18):2428-42 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Jonathan Hodgkin
Evaluated 1 Nov 2002

A regulatory cytoplasmic poly(A) polymerase in Caenorhabditis elegans.
Wang L, Eckmann CR, …, Wickens M, Kimble J
Nature 2002 Sep 19 419(6904):312-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jonathan Hodgkin / Elmar Wahle / Talila Volk / Anita Hopper / Gabriele Varani / Samuel Gunderson
Evaluated 24 Sep 2002

The transformer gene in Ceratitis capitata provides a genetic basis for selecting and remembering the sexual fate.
Pane A, Salvemini M, …, Polito C, Saccone G
Development 2002 Aug 129(15):3715-25 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Jonathan Hodgkin
Evaluated 2 Sep 2002

Loss of the putative RNA-directed RNA polymerase RRF-3 makes C. elegans hypersensitive to RNAi.
Simmer F, Tijsterman M, …, Ahringer J, Plasterk RH
Curr Biol 2002 Aug 6 12(15):1317-9 [abstract on PubMed] [related articles] [order article]
Selected by | Jonathan Hodgkin
Evaluated 30 Aug 2002

A host parasite interaction rescues Drosophila oogenesis defects.
Starr DJ, Cline TW
Nature 2002 Jul 4 418(6893):76-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jonathan Hodgkin
Evaluated 12 Aug 2002

Identification of genes expressed in C. elegans touch receptor neurons.
Zhang Y, Ma C, …, Kim SK, Chalfie M
Nature 2002 Jul 18 418(6895):331-5 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jonathan Hodgkin / Oliver Hobert
Evaluated 22 Jul 2002

DMY is a Y-specific DM-domain gene required for male development in the medaka fish.
Matsuda M, Nagahama Y, …, Hamaguchi S, Sakaizumi M
Nature 2002 May 30 417(6888):559-63 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jonathan Hodgkin / Mark Van Doren
Evaluated 4 Jul 2002

A global analysis of Caenorhabditis elegans operons.
Blumenthal T, Evans D, …, Kiraly M, Kim SK
Nature 2002 Jun 20 417(6891):851-4 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jonathan Hodgkin / Arcady Mushegian / Miles Wilkinson
Evaluated 24 Jun 2002