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Sergio Grinstein
The Hospital for Sick Children (Sick Kids), Canada

Faculty Member: Immunology > Innate Immunity [ since 27 May 2002 ]
[ Sponsorship ] [ Evaluations ]
Sponsorship

Sergio Grinstein sponsors free access to F1000 for Universidad de Guanajuato, Guanajuato, Mexico. Supporting F1000's initiative to make itself available to scientists in all countries, including free access to developing countries (more details).

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Evaluations

Evasion of peptide, but not lipid antigen presentation, through pathogen-induced dendritic cell maturation.
Hava DL, van der Wel N, …, Peters PJ, Brenner MB
Proc Natl Acad Sci U S A 2008 Aug 12 105(32):11281-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Sergio Grinstein with Ronald Flannagan
Evaluated 28 Aug 2008

Coordinated Lipid Transfer between the Endoplasmic Reticulum and the Golgi Complex Requires the VAP Proteins and Is Essential for Golgi-mediated Transport.
Peretti D, Dahan N, …, Hirschberg K, Lev S
Mol Biol Cell 2008 Jul 9 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Sergio Grinstein with Mirkka Koivusalo
Evaluated 7 Aug 2008

The NALP3 inflammasome is involved in the innate immune response to amyloid-beta.
Halle A, Hornung V, …, Moore KJ, Golenbock DT
Nat Immunol 2008 Aug 9(8):857-65 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Xiaojing Ma / Sergio Grinstein with Gregory Fairn
Evaluated 7 Aug 2008


A membrane protein preserves intrabacterial pH in intraphagosomal Mycobacterium tuberculosis.
Vandal OH, Pierini LM, …, Nathan CF, Ehrt S
Nat Med 2008 Jul 20 [abstract on PubMed] [related articles] [full text]
Selected by | Sergio Grinstein with Ronald Flannagan
Evaluated 7 Aug 2008

Subversion of CtBP1-controlled macropinocytosis by human adenovirus serotype 3.
Amstutz B, Gastaldelli M, …, Hemmi S, Greber UF
EMBO J 2008 Apr 9 27(7):956-69 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Sergio Grinstein with Mirkka Koivusalo
Evaluated 30 Jul 2008

Kidney injury molecule-1 is a phosphatidylserine receptor that confers a phagocytic phenotype on epithelial cells.
Ichimura T, Asseldonk EJ, …, Duffield JS, Bonventre JV
J Clin Invest 2008 May 118(5):1657-68 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Norma A. Bobadilla / Sergio Grinstein with Gregory Fairn
Evaluated 30 Jul 2008


Neuraminidase 1 is a negative regulator of lysosomal exocytosis.
Yogalingam G, Bonten EJ, …, Connell SA, d'Azzo A
Dev Cell 2008 Jul 15(1):74-86 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Sergio Grinstein with Mirkka Koivusalo
Evaluated 30 Jul 2008

Role of h2-calponin in regulating macrophage motility and phagocytosis.
Huang QQ, Hossain MM, …, Pope RM, Jin JP
J Biol Chem 2008 Jul 9 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Sergio Grinstein with Ronald Flannagan
Evaluated 30 Jul 2008

Cytokine secretion requires phosphatidylcholine synthesis.
Tian Y, Pate C, …, Claro E, Jackowski S
J Cell Biol 2008 Jun 16 181(6):945-57 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Sergio Grinstein with Gregory Fairn
Evaluated 24 Jul 2008

The closure of Pak1-dependent macropinosomes requires the phosphorylation of CtBP1/BARS.
Liberali P, Kakkonen E, …, Marjomaki V, Luini A
EMBO J 2008 Apr 9 27(7):970-81 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Sergio Grinstein with Mirkka Koivusalo
Evaluated 24 Jul 2008

The complement protein properdin binds apoptotic T cells and promotes complement activation and phagocytosis.
Kemper C, Mitchell LM, Zhang L, Hourcade DE
Proc Natl Acad Sci U S A 2008 Jul 1 105(26):9023-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Sergio Grinstein with Ronald Flannagan
Evaluated 24 Jul 2008

SHIP-1 Increases Early Oxidative Burst and Regulates Phagosome Maturation in Macrophages.
Kamen LA, Levinsohn J, …, Tridandapani S, Swanson JA
J Immunol 2008 Jun 1 180(11):7497-505 [abstract on PubMed] [related articles] [order article]
Selected by | Sergio Grinstein
Evaluated 4 Jun 2008

Live imaging of neuronal degradation by microglia reveals a role for v0-ATPase a1 in phagosomal fusion in vivo.
Peri F, Nüsslein-Volhard C
Cell 2008 May 30 133(5):916-27 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Sergio Grinstein / Siegfried Roth / Sandra Bajjalieh
Evaluated 4 Jun 2008

Mechanism of Inducible Nitric Oxide Synthase Exclusion from Mycobacterial Phagosomes.
Davis AS, Vergne I, …, Chua J, Deretic V
PLoS Pathog 2007 Dec 7 3(12):e186 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Sergio Grinstein / Padmini Salgame
Evaluated 7 Jan 2008

Toll-like receptor signalling in macrophages links the autophagy pathway to phagocytosis.
Sanjuan MA, Dillon CP, …, Withoff S, Green DR
Nature 2007 Dec 20 450(7173):1253-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Sergio Grinstein / George Yap / Daniel Klionsky / Ulrich Schaible
Evaluated 7 Jan 2008


Impaired phagosomal maturation in neutrophils leads to periodontitis in lysosomal-associated membrane protein-2 knockout mice.
Beertsen W, Willenborg M, …, Eskelinen EL, Saftig P
J Immunol 2008 Jan 1 180(1):475-82 [abstract on PubMed] [related articles] [order article]
Selected by | Sergio Grinstein
Evaluated 7 Jan 2008

The dynamic phagosomal proteome and the contribution of the endoplasmic reticulum.
Rogers LD, Foster LJ
Proc Natl Acad Sci U S A 2007 Nov 20 104(47):18520-5 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Sergio Grinstein
Evaluated 17 Dec 2007

Intracellular bacterial growth is controlled by a kinase network around PKB/AKT1.
Kuijl C, Savage ND, …, Ottenhoff TH, Neefjes J
Nature 2007 Nov 29 450(7170):725-30 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Sergio Grinstein / Stefan Kaufmann / Zhong-Yin Zhang
Evaluated 11 Dec 2007

Requirement for a Drosophila E3-ubiquitin ligase in phagocytosis of apoptotic cells.
Silva E, Au-Yeung HW, …, Burden J, Franc NC
Immunity 2007 Oct 27(4):585-96 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Sergio Grinstein
Evaluated 7 Nov 2007

AP-1 and ARF1 control endosomal dynamics at sites of FcR mediated phagocytosis.
Braun V, Deschamps C, …, Chavrier P, Niedergang F
Mol Biol Cell 2007 Dec 18(12):4921-31 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Sergio Grinstein
Evaluated 7 Nov 2007

Transbilayer phospholipid movements in ABCA1-deficient cells.
Williamson P, Halleck MS, Remaley AT, Schlegel RA
PLoS ONE 2007 2:729 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Sergio Grinstein
Evaluated 15 Oct 2007

A cell-free scintillation proximity assay for studies on lysosome-to-phagosome targeting.
Trivedi V, Zhang SC, Stockinger W, Nohturfft A
Sci STKE 2007 Jul 14 2007(392):pl3 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Sergio Grinstein
Evaluated 22 Aug 2007

Flotillin and RacH modulate the intracellular immunity of Dictyostelium to Mycobacterium marinum infection.
Hagedorn M, Soldati T
Cell Microbiol 2007 Nov 9(11):2716-33 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Sergio Grinstein
Evaluated 22 Aug 2007

Assessment of myosin II, Va, VI and VIIa loss of function on endocytosis and endocytic vesicle motility in bone marrow-derived dendritic cells.
Holt JP, Bottomly K, Mooseker MS
Cell Motil Cytoskeleton 2007 Oct 64(10):756-66 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Sergio Grinstein
Evaluated 15 Aug 2007

M. tuberculosis and M. leprae translocate from the phagolysosome to the cytosol in myeloid cells.
van der Wel N, Hava D, …, Brenner M, Peters PJ
Cell 2007 Jun 29 129(7):1287-98 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Marc Lecuit / Padmini Salgame / Sergio Grinstein
Evaluated 10 Aug 2007

A vesicle surface tyrosine kinase regulates phagosome maturation.
Fang J, Brzostowski JA, …, Nair V, Jin T
J Cell Biol 2007 Jul 30 178(3):411-23 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Sergio Grinstein / Richard Gomer
Evaluated 10 Aug 2007

Proteomic analysis of plasma membrane lipid rafts of HL-60 cells.
Yanagida M, Nakayama H, …, Ogawa H, Iwabuchi K
Proteomics 2007 Jul 7(14):2398-409 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Sergio Grinstein
Evaluated 1 Aug 2007

Survival of mycobacteria in macrophages is mediated by coronin 1-dependent activation of calcineurin.
Jayachandran R, Sundaramurthy V, …, Massner J, Pieters J
Cell 2007 Jul 13 130(1):37-50 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Sergio Grinstein / Clifford Harding
Evaluated 1 Aug 2007

Bacteria-generated PtdIns(3)P recruits VAMP8 to facilitate phagocytosis.
Dai S, Zhang Y, …, Yaffe MB, Zhou D
Traffic 2007 Oct 8(10):1365-74 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Sergio Grinstein
Evaluated 1 Aug 2007

Dia1 and IQGAP1 interact in cell migration and phagocytic cup formation.
Brandt DT, Marion S, …, Kaibuchi K, Grosse R
J Cell Biol 2007 Jul 16 178(2):193-200 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Sergio Grinstein
Evaluated 1 Aug 2007

Oxidized phospholipids inhibit phagocytosis and impair outcome in gram-negative sepsis in vivo.
Knapp S, Matt U, Leitinger N, van der Poll T
J Immunol 2007 Jan 15 178(2):993-1001 [abstract on PubMed] [related articles] [order article]
Selected by | Sergio Grinstein
Evaluated 22 Feb 2007

Evidence for phagocytosis of influenza virus-infected, apoptotic cells by neutrophils and macrophages in mice.
Hashimoto Y, Moki T, …, Shiratsuchi A, Nakanishi Y
J Immunol 2007 Feb 15 178(4):2448-57 [abstract on PubMed] [related articles] [order article]
Selected by | Sergio Grinstein
Evaluated 21 Feb 2007

An essential role for talin during alpha(M)beta(2)-mediated phagocytosis.
Lim J, Wiedemann A, …, Critchley DR, Caron E
Mol Biol Cell 2007 Mar 18(3):976-85 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Sergio Grinstein
Evaluated 6 Feb 2007

Salmonella trafficking is defined by continuous dynamic interactions with the endolysosomal system.
Drecktrah D, Knodler LA, Howe D, Steele-Mortimer O
Traffic 2007 Mar 8(3):212-25 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Sergio Grinstein
Evaluated 6 Feb 2007

Ca2+ and synaptotagmin VII-dependent delivery of lysosomal membrane to nascent phagosomes.
Czibener C, Sherer NM, …, Mothes W, Andrews NW
J Cell Biol 2006 174:997-1007 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Sergio Grinstein
Evaluated 10 Nov 2006

Involvement of syntaxin 18, an endoplasmic reticulum (ER)-localized SNARE protein, in ER-mediated phagocytosis.
Hatsuzawa K, Tamura T, …, Nagaya H, Wada I
Mol Biol Cell 2006 Sep 17(9):3964-77 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Sergio Grinstein
Evaluated 19 Jul 2006

pH-dependent pore-forming activity of OmpATb from Mycobacterium tuberculosis and characterization of the channel by peptidic dissection.
Molle V, Saint N, …, Draper P, Molle G
Mol Microbiol 2006 Aug 61(3):826-37 [abstract on PubMed] [related articles] [order article]
Selected by | Sergio Grinstein / Jean Pieters
Evaluated 19 Jul 2006

The cyclic AMP-Epac1-Rap1 pathway is dissociated from regulation of effector functions in monocytes but acquires immunoregulatory function in mature macrophages.
Bryn T, Mahic M, …, Aandahl EM, Taskén K
J Immunol 2006 Jun 15 176(12):7361-70 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Sergio Grinstein
Evaluated 26 Jun 2006

Intracellular Salmonella enterica redirect exocytic transport processes in a Salmonella pathogenicity island 2-dependent manner.
Kuhle V, Abrahams GL, Hensel M
Traffic 2006 Jun 7(6):716-30 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Sergio Grinstein
Evaluated 8 Jun 2006

A phosphatidylinositol-3-kinase-dependent signal transition regulates ARF1 and ARF6 during Fcgamma receptor-mediated phagocytosis.
Beemiller P, Hoppe AD, Swanson JA
PLoS Biol 2006 Jun 4(6):e162 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Sergio Grinstein / Eric Brown
Evaluated 8 Jun 2006

Membrane vesicles shed by Legionella pneumophila inhibit fusion of phagosomes with lysosomes.
Fernandez-Moreira E, Helbig JH, Swanson MS
Infect Immun 2006 Jun 74(6):3285-95 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Miguel Valvano / Sergio Grinstein
Evaluated 7 Jun 2006

Role of target geometry in phagocytosis.
Champion JA, Mitragotri S
Proc Natl Acad Sci U S A 2006 Mar 28 103(13):4930-4 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Sergio Grinstein / Emmanuelle Caron
Evaluated 3 May 2006


Downstream components of RhoA required for signal pathway of superoxide formation during phagocytosis of serum opsonized zymosans in macrophages.
Kim JS, Kim JG, …, Kim PH, Park JB
Exp Mol Med 2005 Dec 31 37(6):575-87 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Sergio Grinstein
Evaluated 16 Jan 2006

Cytolysin-dependent delay of vacuole maturation in macrophages infected with Listeria monocytogenes.
Henry R, Shaughnessy L, …, Higgins DE, Swanson JA
Cell Microbiol 2006 Jan 8(1):107-19 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Sergio Grinstein
Evaluated 9 Jan 2006

Cutting edge: MyD88 controls phagocyte NADPH oxidase function and killing of gram-negative bacteria.
Laroux FS, Romero X, …, Engel P, Terhorst C
J Immunol 2005 Nov 1 175(9):5596-600 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Sergio Grinstein
Evaluated 4 Jan 2006

Identification of Drosophila gene products required for phagocytosis of Candida albicans.
Stroschein-Stevenson SL, Foley E, O'Farrell PH, Johnson AD
PLoS Biol 2006 Jan 4(1):e4 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Sergio Grinstein
Evaluated 21 Dec 2005

A role for mammalian diaphanous-related formins in complement receptor (CR3)-mediated phagocytosis in macrophages.
Colucci-Guyon E, Niedergang F, …, Alberts AS, Chavrier P
Curr Biol 2005 Nov 22 15(22):2007-12 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Sergio Grinstein
Evaluated 14 Dec 2005

Mycobacterial mutants with defective control of phagosomal acidification.
Stewart GR, Patel J, …, Rae A, Young DB
PLoS Pathog 2005 Nov 1(3):269-78 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Sergio Grinstein
Evaluated 14 Dec 2005

The many roads to cross-presentation.
Groothuis TA, Neefjes J
J Exp Med 2005 Nov 21 202(10):1313-8 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Sergio Grinstein
Evaluated 14 Dec 2005

A role for the phagosome in cytokine secretion.
Murray RZ, Kay JG, Sangermani DG, Stow JL
Science 2005 Dec 2 310(5753):1492-5 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Eric Denkers / Sergio Grinstein / Matthew Seaman
Evaluated 14 Dec 2005

Isoform-specific membrane targeting mechanism of Rac during Fc gamma R-mediated phagocytosis: positive charge-dependent and independent targeting mechanism of Rac to the phagosome.
Ueyama T, Eto M, …, Sumimoto H, Saito N
J Immunol 2005 Aug 15 175(4):2381-90 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Sergio Grinstein
Evaluated 22 Aug 2005

Response to Staphylococcus aureus requires CD36-mediated phagocytosis triggered by the COOH-terminal cytoplasmic domain.
Stuart LM, Deng J, …, Ezekowitz RA, Moore KJ
J Cell Biol 2005 Aug 1 170(3):477-85 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Guy Tran Van Nhieu / David Underhill / Sergio Grinstein
Evaluated 17 Aug 2005

Tyrosine phosphatase MptpA of Mycobacterium tuberculosis inhibits phagocytosis and increases actin polymerization in macrophages.
Castandet J, Prost JF, …, Griffiths G, Maridonneau-Parini I
Res Microbiol 2005 Dec 156(10):1005-13 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Sergio Grinstein
Evaluated 17 Aug 2005

WAVE2 signaling mediates invasion of polarized epithelial cells by Salmonella typhimurium.
Shi J, Scita G, Casanova JE
J Biol Chem 2005 Aug 19 280(33):29849-55 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Sergio Grinstein / Andreas Baumler
Evaluated 9 Jun 2005

The intracellular fate of Salmonella depends on the recruitment of kinesin.
Boucrot E, Henry T, …, Gorvel JP, Méresse S
Science 2005 May 20 308(5725):1174-8 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Virginia Miller / Sergio Grinstein
Evaluated 8 Jun 2005

Dectin-1 mediates macrophage recognition of Candida albicans yeast but not filaments.
Gantner BN, Simmons RM, Underhill DM
EMBO J 2005 Mar 23 24(6):1277-86 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Sergio Grinstein / Paula Sundstrom / Siamon Gordon / Joe Heitman
Evaluated 15 Mar 2005

Spatial separation of HLA-DM/HLA-DR interactions within MIIC and phagosome-induced immune escape.
Zwart W, Griekspoor A, …, Jalink K, Neefjes J
Immunity 2005 Feb 22(2):221-33 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Sergio Grinstein
Evaluated 15 Mar 2005

The macrophage alphaMbeta2 integrin alphaM lectin domain mediates the phagocytosis of chilled platelets.
Josefsson EC, Gebhard HH, …, Hartwig JH, Hoffmeister KM
J Biol Chem 2005 May 6 280(18):18025-32 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Sergio Grinstein
Evaluated 9 Mar 2005

Dynamic molecular interactions linking the T cell antigen receptor to the actin cytoskeleton.
Barda-Saad M, Braiman A, …, Barr VA, Samelson LE
Nat Immunol 2005 Jan 6(1):80-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Sergio Grinstein / Michael Dustin
Evaluated 13 Dec 2004

In vivo analysis of 3-phosphoinositide dynamics during Dictyostelium phagocytosis and chemotaxis.
Dormann D, Weijer G, Dowler S, Weijer CJ
J Cell Sci 2004 Dec 15 117(Pt 26):6497-509 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Sergio Grinstein
Evaluated 13 Dec 2004

Modulation of cellular phosphatidylinositol 3-phosphate levels in primary macrophages affects heat-killed but not viable Mycobacterium avium's transport through the phagosome maturation process.
Kelley VA, Schorey JS
Cell Microbiol 2004 Oct 6(10):973-85 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Sergio Grinstein
Evaluated 1 Nov 2004

TI-VAMP/VAMP7 is required for optimal phagocytosis of opsonised particles in macrophages.
Braun V, Fraisier V, …, Galli T, Niedergang F
EMBO J 2004 Oct 27 23(21):4166-76 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Sergio Grinstein
Evaluated 1 Nov 2004

RIAM, an Ena/VASP and Profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesion.
Lafuente EM, van Puijenbroek AA, …, Gertler FB, Boussiotis VA
Dev Cell 2004 Oct 7(4):585-95 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Sergio Grinstein / Denise Montell
Evaluated 1 Nov 2004

A novel phosphatidylinositol(3,4,5)P3 pathway in fission yeast.
Mitra P, Zhang Y, …, Cantley LC, Ross AH
J Cell Biol 2004 Jul 19 166(2):2