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Stevan Hubbard
Skirball Institute, New York University School of Medicine, New York, United States of America

Faculty Member: Structural Biology > Cell Signalling & Trafficking Structures [ since 11 July 2001 ]
[ Evaluations ]
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Evaluations

Structural Basis for the Recognition of c-Src by Its Inactivator Csk.
Levinson NM, Seeliger MA, Cole PA, Kuriyan J
Cell 2008 Jul 11 134(1):124-34 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Stevan Hubbard
Evaluated 18 Jul 2008

CASK Functions as a Mg2+-independent neurexin kinase.
Mukherjee K, Sharma M, …, Südhof TC, Wahl MC
Cell 2008 Apr 18 133(2):328-39 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Carmen Dessauer / Stevan Hubbard / Michael Ehlers
Evaluated 12 May 2008

Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface.
Zhang X, Pickin KA, …, Cole PA, Kuriyan J
Nature 2007 Nov 29 450(7170):741-4 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Stevan Hubbard / Frank Sicheri
Evaluated 10 Dec 2007

Structural basis for activation of the receptor tyrosine kinase KIT by stem cell factor.
Yuzawa S, Opatowsky Y, …, Lax I, Schlessinger J
Cell 2007 Jul 27 130:323-34 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Stevan Hubbard
Evaluated 6 Aug 2007

Structures of lung cancer-derived EGFR mutants and inhibitor complexes: mechanism of activation and insights into differential inhibitor sensitivity.
Yun CH, Boggon TJ, …, Meyerson M, Eck MJ
Cancer Cell 2007 Mar 11(3):217-27 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Robert Fecik / Stevan Hubbard
Evaluated 4 Apr 2007

Structure of the insulin receptor ectodomain reveals a folded-over conformation.
McKern NM, Lawrence MC, …, Epa VC, Ward CW
Nature 2006 Sep 14 443(7108):218-21 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Stevan Hubbard / Jia-huai Wang
Evaluated 22 Sep 2006

An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor.
Zhang X, Gureasko J, …, Cole PA, Kuriyan J
Cell 2006 Jun 16 125(6):1137-49 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Giulio Superti-Furga / Stevan Hubbard / Xiayang Qiu / Gourisankar Ghosh / Karen Anderson / Elizabeth Goldsmith / Friedemann Kiefer / Jane Endicott / Frank Sicheri
Evaluated 23 Jun 2006

Structural basis by which alternative splicing modulates the organizer activity of FGF8 in the brain.
Olsen SK, Li JY, …, Joyner AL, Mohammadi M
Genes Dev 2006 Jan 15 20(2):185-98 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Harukazu Nakamura / Michael Stern / Ivor Mason / Stevan Hubbard
Evaluated 31 Jan 2006

Higher-order substrate recognition of eIF2alpha by the RNA-dependent protein kinase PKR.
Dar AC, Dever TE, Sicheri F
Cell 2005 Sep 23 122(6):887-900 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Stevan Hubbard / Gourisankar Ghosh
Evaluated 13 Oct 2005

The C2 domain of PKCdelta is a phosphotyrosine binding domain.
Benes CH, Wu N, …, Cantley LC, Soltoff SP
Cell 2005 Apr 22 121(2):271-80 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Stevan Hubbard / Susan Steinberg / Liang Tong
Evaluated 26 Apr 2005

A phenylalanine zipper mediates APS dimerization.
Dhe-Paganon S, Werner ED, …, Chi YI, Shoelson SE
Nat Struct Mol Biol 2004 Oct 11(10):968-74 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Stevan Hubbard
Evaluated 4 Jan 2005

Allosteric inhibition of protein tyrosine phosphatase 1B.
Wiesmann C, Barr KJ, …, McDowell RS, Hansen SK
Nat Struct Mol Biol 2004 Aug 11(8):730-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Stevan Hubbard / Celerino Abad-Zapatero / Wolfgang Jahnke / Zhong-Yin Zhang / Amy Barrios
Evaluated 26 Jul 2004

The structural basis for autoinhibition of FLT3 by the juxtamembrane domain.
Griffith J, Black J, …, Lippke J, Saxena K
Mol Cell 2004 Jan 30 13(2):169-78 [abstract on PubMed] [related articles] [order article]
Selected by | Stevan Hubbard
Evaluated 11 Mar 2004

Bypassing a kinase activity with an ATP-competitive drug.
Papa FR, Zhang C, Shokat K, Walter P
Science 2003 Nov 28 302(5650):1533-7 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Anthony Means / Stevan Hubbard / Robert Kelley / Charles Brenner
Evaluated 19 Dec 2003

Origins of peptide selectivity and phosphoinositide binding revealed by structures of disabled-1 PTB domain complexes.
Stolt PC, Jeon H, …, Eck MJ, Blacklow SC
Structure 2003 May 11(5):569-79 [abstract on PubMed] [related articles] [order article]
Selected by | Liang Tong / Stevan Hubbard
Evaluated 27 May 2003

The role of C-terminal tyrosine phosphorylation in the regulation of SHP-1 explored via expressed protein ligation.
Zhang Z, Shen K, Lu W, Cole PA
J Biol Chem 2003 Feb 14 278(7):4668-74 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Stevan Hubbard
Evaluated 11 Feb 2003

APS facilitates c-Cbl tyrosine phosphorylation and GLUT4 translocation in response to insulin in 3T3-L1 adipocytes.
Liu J, Kimura A, Baumann CA, Saltiel AR
Mol Cell Biol 2002 Jun 22(11):3599-609 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Stevan Hubbard
Evaluated 5 Sep 2002

Molecular mechanism for the regulation of protein kinase B/Akt by hydrophobic motif phosphorylation.
Yang J, Cron P, …, Hemmings BA, Barford D
Mol Cell 2002 Jun 9(6):1227-40 [abstract on PubMed] [related articles] [order article]
Selected by | Alexandra Newton / Stevan Hubbard / Chandra Kumar / Patricia Jennings
Evaluated 5 Jul 2002

Crystal structure of an Eph receptor-ephrin complex.
Himanen JP, Rajashankar KR, …, Henkemeyer M, Nikolov DB
Nature 2001 Dec 20-27 414(6866):933-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Stevan Hubbard
Evaluated 21 Jan 2002

Structural basis for autoinhibition of the Ephb2 receptor tyrosine kinase by the unphosphorylated juxtamembrane region.
Wybenga-Groot LE, Baskin B, …, Pawson T, Sicheri F
Cell 2001 Sep 21 106(6):745-57 [abstract on PubMed] [related articles] [order article]
Selected by | Michael Greenberg / Robert Liddington / Michael Schaller / Stevan Hubbard
Evaluated 25 Oct 2001

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