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Patrick Tam
Embryology Unit, Childrens Medical Research Institute, Wentworthville, Sydney, Australia

Faculty Member: DEVELOPMENTAL BIOLOGY > Morphogenesis & cell biology [ since 9 July 2001 ]
[ Sponsorship ] [ Biography ] [ Evaluations ]
Sponsorship

Patrick Tam sponsors free access to F1000 for Nelson Mandela Metropolitan University. Supporting F1000's initiative to make itself available to scientists in all countries, including free access to developing countries (more details).

Biography

Dr Patrick Tam is a Senior Principal Research Fellow of the Faculty of Medicine, University of Sydney and the Head of Embryology Unit at the Children's Medical Research Institute. His research focuses on the elucidation of the cellular and molecular mechanisms of the tissue patterning and the development of the craniofacial structures in the mouse embryo. Specifically, he examines the morphogenetic role of the mouse gastrula organizer in patterning the neural primordium during early embryogenesis. He pioneers the application of micromanipulation and embryo culture for analysing tissue potency and lineage specification in mutant embryos generated by gene targeting.

Dr David Leobel, Kimberly-Clark Research Fellow of my research team, assists me with the evaluations for Faculty of 1000.

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Evaluations

An Fgf/Gremlin inhibitory feedback loop triggers termination of limb bud outgrowth.
Verheyden JM, Sun X
Nature 2008 Advance Online Publication [full text]
Selected by | Patrick Tam
Evaluated 3 Jul 2008

Genetic evidence that FGFs have an instructive role in limb proximal-distal patterning.
Mariani FV, Ahn CP, Martin GR
Nature 2008 May 15 453(7193):401-5 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Patrick Tam / Harukazu Nakamura
Evaluated 21 May 2008

Prevention of the neurocristopathy Treacher Collins syndrome through inhibition of p53 function.
Jones NC, Lynn ML, …, Dixon MJ, Trainor PA
Nat Med 2008 Feb 14(2):125-33 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Peter Scambler / Patrick Tam
Evaluated 26 Mar 2008

MicroRNA Mirn140 modulates Pdgf signaling during palatogenesis.
Eberhart JK, He X, …, Kimmel CB, Postlethwait JH
Nat Genet 2008 Mar 40(3):290-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Patrick Tam
Evaluated 26 Mar 2008

Proximal visceral endoderm and extraembryonic ectoderm regulate the formation of primordial germ cell precursors.
Chuva de Sousa Lopes SM, Hayashi K, Surani MA
BMC Dev Biol 2007 Dec 20 7(1):140 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Patrick Tam
Evaluated 8 Jan 2008

Live imaging and genetic analysis of mouse notochord formation reveals regional morphogenetic mechanisms.
Yamanaka Y, Tamplin OJ, …, Gossler A, Rossant J
Dev Cell 2007 Dec 13(6):884-96 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Patrick Tam / Scott Holley
Evaluated 7 Jan 2008

The amniote primitive streak is defined by epithelial cell intercalation before gastrulation.
Voiculescu O, Bertocchini F, …, Keller RE, Stern CD
Nature 2007 Oct 25 449(7165):1049-52 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Thomas Lecuit / Victoria Prince / Patrick Tam / Jeffrey Axelrod
Evaluated 23 Nov 2007

X chromosome reactivation initiates in nascent primordial germ cells in mice.
Sugimoto M, Abe K
PLoS Genet 2007 Jul 27 3(7):e116 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Patrick Tam
Evaluated 17 Aug 2007

Visualization of cartilage formation: insight into cellular properties of skeletal progenitors and chondrodysplasia syndromes.
Barna M, Niswander L
Dev Cell 2007 Jun 12(6):931-41 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Patrick Tam
Evaluated 11 Jul 2007


The graded response to Sonic Hedgehog depends on cilia architecture.
Caspary T, Larkins CE, Anderson KV
Dev Cell 2007 May 12(5):767-78 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Patrick Tam
Evaluated 30 May 2007

The FERM protein Epb4.1l5 is required for organization of the neural plate and for the epithelial-mesenchymal transition at the primitive streak of the mouse embryo.
Lee JD, Silva-Gagliardi NF, …, McGlade CJ, Anderson KV
Development 2007 Jun 134(11):2007-16 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Patrick Tam / Deborah Andrew
Evaluated 29 May 2007

Crucial roles of Foxa2 in mouse anterior-posterior axis polarization via regulation of anterior visceral endoderm-specific genes.
Kimura-Yoshida C, Tian E, …, Aizawa S, Matsuo I
Proc Natl Acad Sci U S A 2007 Apr 3 104(14):5919-24 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Patrick Tam
Evaluated 16 Apr 2007

An Nkx2-5/Bmp2/Smad1 negative feedback loop controls heart progenitor specification and proliferation.
Prall OW, Menon MK, …, Buckingham ME, Harvey RP
Cell 2007 Mar 9 128(5):947-59 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Stephen Dalton / Patrick Tam / Peter Scambler
Evaluated 22 Mar 2007

Gata-3 is an essential regulator of mammary-gland morphogenesis and luminal-cell differentiation.
Asselin-Labat ML, Sutherland KD, …, Lindeman GJ, Visvader JE
Nat Cell Biol 2007 Feb 9(2):201-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Patrick Tam
Evaluated 22 Feb 2007

A complex oscillating network of signaling genes underlies the mouse segmentation clock.
Dequéant ML, Glynn E, …, Mushegian A, Pourquié O
Science 2006 Dec 8 314(5805):1595-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jane Hewitt / David Wilkinson / Patrick Tam
Evaluated 16 Jan 2007

Shisa2 promotes the maturation of somitic precursors and transition to the segmental fate in Xenopus embryos.
Nagano T, Takehara S, …, Aizawa S, Yamamoto A
Development 2006 Dec 133(23):4643-54 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Patrick Tam
Evaluated 19 Dec 2006

A dynamic fate map of the forebrain shows how vertebrate eyes form and explains two causes of cyclopia.
England SJ, Blanchard GB, Mahadevan L, Adams RJ
Development 2006 Dec 133(23):4613-7 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Patrick Tam
Evaluated 13 Nov 2006

A role for the hypoblast (AVE) in the initiation of neural induction, independent of its ability to position the primitive streak.
Albazerchi A, Stern CD
Dev Biol 2007 Jan 15 301(2):489-503 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Patrick Tam
Evaluated 26 Sep 2006

In vitro-differentiated embryonic stem cells give rise to male gametes that can generate offspring mice.
Nayernia K, Nolte J, …, Meinhardt A, Engel W
Dev Cell 2006 Jul 11(1):125-32 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Harvey Florman / Patrick Tam
Evaluated 1 Aug 2006

Developmental abnormalities of NT mouse embryos appear early after implantation.
Jouneau A, Zhou Q, …, Collignon J, Renard JP
Development 2006 Apr 133(8):1597-607 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Patrick Tam
Evaluated 5 Jun 2006

The mouse embryo autonomously acquires anterior-posterior polarity at implantation.
Takaoka K, Yamamoto M, …, Saijoh Y, Hamada H
Dev Cell 2006 Apr 10(4):451-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Patrick Tam
Evaluated 21 Apr 2006

Motoneurons and oligodendrocytes are sequentially generated from neural stem cells but do not appear to share common lineage-restricted progenitors in vivo.
Wu S, Wu Y, Capecchi MR
Development 2006 Feb 133(4):581-90 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Patrick Tam
Evaluated 10 Feb 2006

The Vg1-related protein Gdf3 acts in a Nodal signaling pathway in the pre-gastrulation mouse embryo.
Chen C, Ware SM, …, Shen MM, Brown CW
Development 2006 Jan 133(2):319-29 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Patrick Tam / Claudio Stern
Evaluated 4 Jan 2006

Efficient differentiation of human embryonic stem cells to definitive endoderm.
D'Amour KA, Agulnick AD, …, Kroon E, Baetge EE
Nat Biotechnol 2005 Dec 23(12):1534-41 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Kenneth Zaret / Patrick Tam
Evaluated 4 Nov 2005

Fate-mapping of the epithelial seam during palatal fusion rules out epithelial-mesenchymal transformation.
Vaziri Sani F, Hallberg K, …, Linde A, Gritli-Linde A
Dev Biol 2005 Sep 15 285(2):490-5 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Michael M Shen / Patrick Tam
Evaluated 4 Nov 2005

Oocyte generation in adult mammalian ovaries by putative germ cells in bone marrow and peripheral blood.
Johnson J, Bagley J, …, Scadden DT, Tilly JL
Cell 2005 Jul 29 122(2):303-15 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Patrick Tam / William H. Colledge
Evaluated 11 Aug 2005

Blimp1 is a critical determinant of the germ cell lineage in mice.
Ohinata Y, Payer B, …, Saitou M, Surani MA
Nature 2005 Jul 14 436(7048):207-13 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Erez Raz / Patrick Tam / Kate Loveland
Evaluated 5 Jul 2005

Xlr3b is a new imprinted candidate for X-linked parent-of-origin effects on cognitive function in mice.
Davies W, Isles A, …, Burgoyne P, Wilkinson L
Nat Genet 2005 Jun 37(6):625-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Patrick Tam / Carmen Sapienza
Evaluated 30 Jun 2005

Four-cell stage mouse blastomeres have different developmental properties.
Piotrowska-Nitsche K, Perea-Gomez A, Haraguchi S, Zernicka-Goetz M
Development 2005 Feb 132(3):479-90 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Patrick Tam
Evaluated 5 May 2005

Mitotic spindles and cleavage planes are oriented randomly in the two-cell mouse embryo.
Louvet-Vallée S, Vinot S, Maro B
Curr Biol 2005 Mar 8 15(5):464-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Patrick Tam
Evaluated 22 Mar 2005

Directed differentiation of telencephalic precursors from embryonic stem cells.
Watanabe K, Kamiya D, …, Mizuseki K, Sasai Y
Nat Neurosci 2005 Mar 8(3):288-96 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Arturo Alvarez-Buylla / Patrick Tam
Evaluated 11 Mar 2005

Genetic analysis of interactions between the somitic muscle, cartilage and tendon cell lineages during mouse development.
Brent AE, Braun T, Tabin CJ
Development 2005 Feb 132(3):515-28 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Patrick Tam
Evaluated 23 Feb 2005

Spermatogenesis from epiblast and primordial germ cells following transplantation into postnatal mouse testis.
Chuma S, Kanatsu-Shinohara M, …, Ogura A, Shinohara T
Development 2005 Jan 132(1):117-22 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Patrick Tam
Evaluated 14 Jan 2005

Haemangioblast commitment is initiated in the primitive streak of the mouse embryo.
Huber TL, Kouskoff V, …, Palis J, Keller G
Nature 2004 Dec 2 432(7017):625-30 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Daniel Constam / Patrick Tam / Azim Surani / Roger Patient / Elaine Dzierzak
Evaluated 8 Dec 2004

Retrotransposons regulate host genes in mouse oocytes and preimplantation embryos.
Peaston AE, Evsikov AV, …, Solter D, Knowles BB
Dev Cell 2004 Oct 7(4):597-606 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Patrick Tam / Marie-Angele Grandbastien
Evaluated 29 Oct 2004

Refinement of gene expression patterns in the early Xenopus embryo.
Wardle FC, Smith JC
Development 2004 Oct 131(19):4687-96 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Patrick Tam / Claudio Stern
Evaluated 17 Sep 2004

BMP signaling mediated by ALK2 in the visceral endoderm is necessary for the generation of primordial germ cells in the mouse embryo.
de Sousa Lopes SM, Roelen BA, …, Lawson KA, Mummery CL
Genes Dev 2004 Aug 1 18(15):1838-49 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Patrick Tam / Kate Loveland
Evaluated 17 Sep 2004

A two-step mechanism for myotome formation in chick.
Gros J, Scaal M, Marcelle C
Dev Cell 2004 Jun 6(6):875-82 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Patrick Tam / Chaya Kalcheim / Olivier Pourquie
Evaluated 21 Jul 2004

First cleavage plane of the mouse egg is not predetermined but defined by the topology of the two apposing pronuclei.
Hiiragi T, Solter D
Nature 2004 Jul 15 430(6997):360-4 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Patrick Tam
Evaluated 21 Jul 2004

Sox17 and beta-catenin cooperate to regulate the transcription of endodermal genes.
Sinner D, Rankin S, Lee M, Zorn AM
Development 2004 Jul 131(13):3069-80 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Patrick Tam
Evaluated 1 Jul 2004

Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation.
Dor Y, Brown J, Martinez OI, Melton DA
Nature 2004 May 6 429(6987):41-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Patrick Tam / Anthony Means / Ueli Schibler
Evaluated 14 May 2004

Nodal antagonists regulate formation of the anteroposterior axis of the mouse embryo.
Yamamoto M, Saijoh Y, …, Hamada H, Meno C
Nature 2004 Mar 25 428(6981):387-92 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Patrick Tam / Magdalena Zernicka-Goetz
Evaluated 23 Mar 2004

The anterior-posterior axis emerges respecting the morphology of the mouse embryo that changes and aligns with the uterus before gastrulation.
Mesnard D, Filipe M, Belo JA, Zernicka-Goetz M
Curr Biol 2004 Feb 3 14(3):184-96 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Patrick Tam
Evaluated 10 Mar 2004

Initiation of gastrulation in the mouse embryo is preceded by an apparent shift in the orientation of the anterior-posterior axis.
Perea-Gomez A, Camus A, …, Cibert C, Collignon J
Curr Biol 2004 Feb 3 14(3):197-207 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Patrick Tam
Evaluated 10 Mar 2004

Active cell migration drives the unilateral movements of the anterior visceral endoderm.
Srinivas S, Rodriguez T, …, Smith JC, Beddington RS
Development 2004 Mar 131(5):1157-64 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Patrick Tam
Evaluated 10 Mar 2004

Zebrafish pou5f1/pou2, homolog of mammalian Oct4, functions in the endoderm specification cascade.
Lunde K, Belting HG, Driever W
Curr Biol 2004 Jan 6 14(1):48-55 [abstract on PubMed] [related articles] [order article]
Selected by | Patrick Tam / David Kimelman
Evaluated 22 Jan 2004

A positive-feedback-based bistable 'memory module' that governs a cell fate decision.
Xiong W, Ferrell JE
Nature 2003 Nov 27 426(6965):460-5 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Claudio Stern / Patrick Tam / Hiten Madhani
Evaluated 10 Dec 2003

Stella is a maternal effect gene required for normal early development in mice.
Payer B, Saitou M, …, Nakano T, Surani MA
Curr Biol 2003 Dec 2 13(23):2110-7 [abstract on PubMed] [related articles] [order article]
Selected by | Patrick Tam
Evaluated 10 Dec 2003

The maternally expressed zebrafish T-box gene eomesodermin regulates organizer formation.
Bruce AE, Howley C, …, King ML, Ho RK
Development 2003 Nov 130(22):5503-17 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Patrick Tam
Evaluated 15 Oct 2003

Analysis of cell lineage in two- and four-cell mouse embryos.
Fujimori T, Kurotaki Y, Miyazaki J, Nabeshima Y
Development 2003 Nov 130(21):5113-22 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Patrick Tam
Evaluated 5 Sep 2003

Cryptic boundaries in roof plate and choroid plexus identified by intersectional gene activation.
Awatramani R, Soriano P, …, Mai JJ, Dymecki SM
Nat Genet 2003 Sep 35(1):70-5 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Patrick Tam
Evaluated 5 Sep 2003

Two populations of node monocilia initiate left-right asymmetry in the mouse.
McGrath J, Somlo S, …, Tian X, Brueckner M
Cell 2003 Jul 11 114(1):61-73 [abstract on PubMed] [related articles] [order article]
Selected by | Patrick Tam / Carl Thummel / George Witman
Evaluated 28 Jul 2003

Periodic repression by the bHLH factor Hes7 is an essential mechanism for the somite segmentation clock.
Bessho Y, Hirata H, Masamizu Y, Kageyama R
Genes Dev 2003 Jun 15 17(12):1451-6 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Patrick Tam / Sharon Amacher
Evaluated 9 Jul 2003

Molecular link in the sequential induction of the Spemann organizer: direct activation of the cerberus gene by Xlim-1, Xotx2, Mix.1, and Siamois, immediately downstream from Nodal and Wnt signaling.
Yamamoto S, Hikasa H, Ono H, Taira M
Dev Biol 2003 May 1 257(1):190-204 [abstract on PubMed] [related articles] [order article]
Selected by | Patrick Tam
Evaluated 30 May 2003

Transcriptional oscillation of lunatic fringe is essential for somitogenesis.
Serth K, Schuster-Gossler K, Cordes R, Gossler A
Genes Dev 2003 Apr 1 17(7):912-25 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Patrick Tam
Evaluated 29 May 2003

A somitic compartment of tendon progenitors.
Brent AE, Schweitzer R, Tabin CJ
Cell 2003 Apr 18 113(2):235-48 [abstract on PubMed] [related articles] [order article]
Selected by | Claudio Stern / Patrick Tam
Evaluated 29 Apr 2003

Wnt3a plays a major role in the segmentation clock controlling somitogenesis.
Aulehla A, Wehrle C, …, Kanzler B, Herrmann BG
Dev Cell 2003 Mar 4(3):395-406 [abstract on PubMed] [related articles] [order article]
Selected by | Patrick Tam / Scott Holley / Lilianna Solnica-Krezel / David Ish-Horowicz / Olivier Pourquie
Evaluated 20 Mar 2003

Maternal induction of ventral fate by zebrafish radar.
Sidi S, Goutel C, Peyriéras N, Rosa FM
Proc Natl Acad Sci U S A 2003 Mar 18 100(6):3315-20 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Patrick Tam
Evaluated 5 Mar 2003

Extra-embryonic function of Rb is essential for embryonic development and viability.
Wu L, de Bruin A, …, Robinson ML, Leone G
Nature 2003 Feb 27 421(6926):942-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Patrick Tam
Evaluated 5 Mar 2003

Extraembryonic proteases regulate Nodal signalling during gastrulation.
Beck S, Le Good JA, …, Beermann F, Constam DB
Nat Cell Biol 2002 Dec 4(12):981-5 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Malcolm Whitman / Lilianna Solnica-Krezel / Patrick Tam
Evaluated 31 Jan 2003

Xhex-expressing endodermal tissues are essential for anterior patterning in Xenopus.
Smithers LE, Jones CM
Mech Dev 2002 Dec 119(2):191-200 [abstract on PubMed] [related articles] [order article]
Selected by | Patrick Tam
Evaluated 30 Jan 2003

Early patterning of the mouse embryo--contributions of sperm and egg.
Piotrowska K, Zernicka-Goetz M
Development 2002 Dec 129(24):5803-13 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Claudio Stern / Daniel Constam / Patrick Tam
Evaluated 20 Jan 2003

Formation of multiple hearts in mice following deletion of beta-catenin in the embryonic endoderm.
Lickert H, Kutsch S, …, Taketo MM, Kemler R
Dev Cell 2002 Aug 3(2):171-81 [abstract on PubMed] [related articles] [order article]
Selected by | Didier Stainier / Roger Patient / Daniel Constam / Patrick Tam
Evaluated 13 Nov 2002

Association between the cell cycle and neural crest delamination through specific regulation of G1/S transition.
Burstyn-Cohen T, Kalcheim C
Dev Cell 2002 Sep 3(3):383-95 [abstract on PubMed] [related articles] [order article]